Q9E6M6 (DUT_GAHVM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Gene names

Name:

MDV063

Organism

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) [Reference proteome]

Taxonomic identifier

10389 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Mardivirus › Gallid herpesvirus 2

Virus host

Gallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000406499

Sequences

	Sequence		Length	Mass (Da)
	Q9E6M6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 7D6B446ECC7BCDF9	FASTA	436	48,468
	10 20 30 40 50 60 MNVHESHPRR DRDLENITLE ALTVPWRLQF RVDEALYAVN PNGWTCYIEE RDQRCLRVTN 70 80 90 100 110 120 NCVISLLKSD LKRRYQTCTL NIGIRVAVPQ NYVVILAKLT DPDPTSRGIP IIQVANGLID 130 140 150 160 170 180 SGYRGSIRAV LFFEKSCIIP KNGLAIRLSL VKLASPNLNT RVLFNLSDIT PHLECGPDFS 190 200 210 220 230 240 TSIETAVRLG SGETKPLLPP SGGGIWAGTG CRALACLYND RVCKASHYTS SDKNIAFVVR 250 260 270 280 290 300 YNDSTSVLGL KDFPTAEDET FVRFYTSGQF ATLIPFFETF TPKRTEDAAY DIAAPGDIRL 310 320 330 340 350 360 GALSSTTIMI QQRYVCMDDS VIPCIFGRSS MNLRGLIIIP SRWLPNSWLT ITICNLTEMT 370 380 390 400 410 420 VMIRCGDRIA QLLLVDHESA TLIPPTNDTT GMFPTVGKCR RPGASVGEPK WRETLEFDTE 430 AYSSERQFSG FGSTGI

References

[1]	"The genome of a very virulent Marek's disease virus." Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F. J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF243438 Genomic DNA. Translation: AAG14243.1.
RefSeq	YP_001033980.1. NC_002229.3.
3D structure databases
ProteinModelPortal	Q9E6M6.
ModBase	Search...
Proteomic databases
PRIDE	Q9E6M6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4811526.
Phylogenomic databases
ProtClustDB	PHA3129.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_GAHVM

Accession

Primary (citable) accession number: Q9E6M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program