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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:MDV063
OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri10389 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000008072 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004064991 – 436Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST436

Proteomic databases

PRIDEiQ9E6M6.

Structurei

3D structure databases

ProteinModelPortaliQ9E6M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni328 – 330Substrate bindingUniRule annotation3
Regioni431 – 432Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Family and domain databases

Gene3Di2.70.40.10. 2 hits.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9E6M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVHESHPRR DRDLENITLE ALTVPWRLQF RVDEALYAVN PNGWTCYIEE
60 70 80 90 100
RDQRCLRVTN NCVISLLKSD LKRRYQTCTL NIGIRVAVPQ NYVVILAKLT
110 120 130 140 150
DPDPTSRGIP IIQVANGLID SGYRGSIRAV LFFEKSCIIP KNGLAIRLSL
160 170 180 190 200
VKLASPNLNT RVLFNLSDIT PHLECGPDFS TSIETAVRLG SGETKPLLPP
210 220 230 240 250
SGGGIWAGTG CRALACLYND RVCKASHYTS SDKNIAFVVR YNDSTSVLGL
260 270 280 290 300
KDFPTAEDET FVRFYTSGQF ATLIPFFETF TPKRTEDAAY DIAAPGDIRL
310 320 330 340 350
GALSSTTIMI QQRYVCMDDS VIPCIFGRSS MNLRGLIIIP SRWLPNSWLT
360 370 380 390 400
ITICNLTEMT VMIRCGDRIA QLLLVDHESA TLIPPTNDTT GMFPTVGKCR
410 420 430
RPGASVGEPK WRETLEFDTE AYSSERQFSG FGSTGI
Length:436
Mass (Da):48,468
Last modified:March 1, 2001 - v1
Checksum:i7D6B446ECC7BCDF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243438 Genomic DNA. Translation: AAG14243.1.
RefSeqiYP_001033980.1. NC_002229.3.

Genome annotation databases

GeneIDi4811526.
KEGGivg:4811526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243438 Genomic DNA. Translation: AAG14243.1.
RefSeqiYP_001033980.1. NC_002229.3.

3D structure databases

ProteinModelPortaliQ9E6M6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9E6M6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4811526.
KEGGivg:4811526.

Family and domain databases

Gene3Di2.70.40.10. 2 hits.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_GAHVM
AccessioniPrimary (citable) accession number: Q9E6M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.