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Q9E6M6

- DUT_GAHVM

UniProt

Q9E6M6 - DUT_GAHVM

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

MDV063

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Gene namesi
Name:MDV063
OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri10389 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008072: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000406499Add
BLAST

Proteomic databases

PRIDEiQ9E6M6.

Structurei

3D structure databases

ProteinModelPortaliQ9E6M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 2 hits.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9E6M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVHESHPRR DRDLENITLE ALTVPWRLQF RVDEALYAVN PNGWTCYIEE
60 70 80 90 100
RDQRCLRVTN NCVISLLKSD LKRRYQTCTL NIGIRVAVPQ NYVVILAKLT
110 120 130 140 150
DPDPTSRGIP IIQVANGLID SGYRGSIRAV LFFEKSCIIP KNGLAIRLSL
160 170 180 190 200
VKLASPNLNT RVLFNLSDIT PHLECGPDFS TSIETAVRLG SGETKPLLPP
210 220 230 240 250
SGGGIWAGTG CRALACLYND RVCKASHYTS SDKNIAFVVR YNDSTSVLGL
260 270 280 290 300
KDFPTAEDET FVRFYTSGQF ATLIPFFETF TPKRTEDAAY DIAAPGDIRL
310 320 330 340 350
GALSSTTIMI QQRYVCMDDS VIPCIFGRSS MNLRGLIIIP SRWLPNSWLT
360 370 380 390 400
ITICNLTEMT VMIRCGDRIA QLLLVDHESA TLIPPTNDTT GMFPTVGKCR
410 420 430
RPGASVGEPK WRETLEFDTE AYSSERQFSG FGSTGI
Length:436
Mass (Da):48,468
Last modified:March 1, 2001 - v1
Checksum:i7D6B446ECC7BCDF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14243.1.
RefSeqiYP_001033980.1. NC_002229.3.

Genome annotation databases

GeneIDi4811526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14243.1 .
RefSeqi YP_001033980.1. NC_002229.3.

3D structure databases

ProteinModelPortali Q9E6M6.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9E6M6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4811526.

Family and domain databases

Gene3Di 2.70.40.10. 2 hits.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "The genome of a very virulent Marek's disease virus."
    Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
    J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_GAHVM
AccessioniPrimary (citable) accession number: Q9E6M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3