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Q9E6M6 (DUT_GAHVM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Gene names
Name:MDV063
OrganismGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) [Reference proteome]
Taxonomic identifier10389 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000406499

Sequences

Sequence LengthMass (Da)Tools
Q9E6M6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7D6B446ECC7BCDF9

FASTA43648,468
        10         20         30         40         50         60 
MNVHESHPRR DRDLENITLE ALTVPWRLQF RVDEALYAVN PNGWTCYIEE RDQRCLRVTN 

        70         80         90        100        110        120 
NCVISLLKSD LKRRYQTCTL NIGIRVAVPQ NYVVILAKLT DPDPTSRGIP IIQVANGLID 

       130        140        150        160        170        180 
SGYRGSIRAV LFFEKSCIIP KNGLAIRLSL VKLASPNLNT RVLFNLSDIT PHLECGPDFS 

       190        200        210        220        230        240 
TSIETAVRLG SGETKPLLPP SGGGIWAGTG CRALACLYND RVCKASHYTS SDKNIAFVVR 

       250        260        270        280        290        300 
YNDSTSVLGL KDFPTAEDET FVRFYTSGQF ATLIPFFETF TPKRTEDAAY DIAAPGDIRL 

       310        320        330        340        350        360 
GALSSTTIMI QQRYVCMDDS VIPCIFGRSS MNLRGLIIIP SRWLPNSWLT ITICNLTEMT 

       370        380        390        400        410        420 
VMIRCGDRIA QLLLVDHESA TLIPPTNDTT GMFPTVGKCR RPGASVGEPK WRETLEFDTE 

       430 
AYSSERQFSG FGSTGI 

« Hide

References

[1]"The genome of a very virulent Marek's disease virus."
Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF243438 Genomic DNA. Translation: AAG14243.1.
RefSeqYP_001033980.1. NC_002229.3.

3D structure databases

ProteinModelPortalQ9E6M6.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9E6M6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4811526.

Phylogenomic databases

ProtClustDBPHA3129.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_GAHVM
AccessionPrimary (citable) accession number: Q9E6M6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families