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Q9E6M6

- DUT_GAHVM

UniProt

Q9E6M6 - DUT_GAHVM

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

MDV063

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Gene namesi
    Name:MDV063
    OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
    Taxonomic identifieri10389 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    ProteomesiUP000008072: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000406499Add
    BLAST

    Proteomic databases

    PRIDEiQ9E6M6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9E6M6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 2 hits.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9E6M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVHESHPRR DRDLENITLE ALTVPWRLQF RVDEALYAVN PNGWTCYIEE    50
    RDQRCLRVTN NCVISLLKSD LKRRYQTCTL NIGIRVAVPQ NYVVILAKLT 100
    DPDPTSRGIP IIQVANGLID SGYRGSIRAV LFFEKSCIIP KNGLAIRLSL 150
    VKLASPNLNT RVLFNLSDIT PHLECGPDFS TSIETAVRLG SGETKPLLPP 200
    SGGGIWAGTG CRALACLYND RVCKASHYTS SDKNIAFVVR YNDSTSVLGL 250
    KDFPTAEDET FVRFYTSGQF ATLIPFFETF TPKRTEDAAY DIAAPGDIRL 300
    GALSSTTIMI QQRYVCMDDS VIPCIFGRSS MNLRGLIIIP SRWLPNSWLT 350
    ITICNLTEMT VMIRCGDRIA QLLLVDHESA TLIPPTNDTT GMFPTVGKCR 400
    RPGASVGEPK WRETLEFDTE AYSSERQFSG FGSTGI 436
    Length:436
    Mass (Da):48,468
    Last modified:March 1, 2001 - v1
    Checksum:i7D6B446ECC7BCDF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243438 Genomic DNA. Translation: AAG14243.1.
    RefSeqiYP_001033980.1. NC_002229.3.

    Genome annotation databases

    GeneIDi4811526.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243438 Genomic DNA. Translation: AAG14243.1 .
    RefSeqi YP_001033980.1. NC_002229.3.

    3D structure databases

    ProteinModelPortali Q9E6M6.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9E6M6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4811526.

    Family and domain databases

    Gene3Di 2.70.40.10. 2 hits.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of a very virulent Marek's disease virus."
      Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
      J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_GAHVM
    AccessioniPrimary (citable) accession number: Q9E6M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3