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Q9E3M8 (Q9E3M8_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:pol EMBL AAG28668.1
OrganismHuman immunodeficiency virus 1 EMBL AAG28668.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length99 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains peptidase A2 domain. SAAS SAAS018061

Contains peptidase Adomain. SAAS SAAS018061

Ontologies

Keywords
   Molecular functionAspartyl protease RuleBase RU000453
Hydrolase
Protease
   Technical term3D-structure PDB 2AZC PDB 2HB2 PDB 2HC0
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAG28668.1
Non-terminal residue991 EMBL AAG28668.1

Sequences

Sequence LengthMass (Da)Tools
Q9E3M8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 015539B069915479

FASTA9910,724
        10         20         30         40         50         60 
PQITLWQRPL VTIKIGGQLK EALIDTGADD TVLEEMNLPG RWKPKIIGGI GGIIKVRQYD 

        70         80         90 
QIPIEICGHK AIGTVLVGPT PANIIGRNLL TQIGCTLNF 

« Hide

References

[1]"Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen."
Izopet J., Massip P., Souyris C., Sandres K., Puissant B., Obadia M., Pasquier C., Bonnet E., Marchou B., Puel J.
AIDS 14:2247-2255(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure of HIV Protease 6X Mutant in complex with AB-2."
Heaslet H., Brik A., Lin Y.-C., Elder J.H., Stout C.D.
Submitted (JUN-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
[3]"Conformational flexibility in the flap domains of ligand-free HIV protease."
Heaslet H., Rosenfeld R., Giffin M., Lin Y.C., Tam K., Torbett B.E., Elder J.H., McRee D.E., Stout C.D.
Acta Crystallogr. D 63:866-875(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF264323 Genomic RNA. Translation: AAG28668.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HB2X-ray2.30A1-99[»]
2HC0X-ray1.30A/B1-99[»]
ProteinModelPortalQ9E3M8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.70.10. 1 hit.
InterProIPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMSSF50630. SSF50630. 1 hit.
PROSITEPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9E3M8_9HIV1
AccessionPrimary (citable) accession number: Q9E3M8
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)