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Q9E3M8

- Q9E3M8_9HIV1

UniProt

Q9E3M8 - Q9E3M8_9HIV1

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Protein
Submitted name:

Protease

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotation, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Submitted name:
ProteaseImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HB2X-ray2.30A1-99[»]
2HC0X-ray1.30A/B1-99[»]
ProteinModelPortaliQ9E3M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains peptidase A2 domain.SAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9E3M8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PQITLWQRPL VTIKIGGQLK EALIDTGADD TVLEEMNLPG RWKPKIIGGI
60 70 80 90
GGIIKVRQYD QIPIEICGHK AIGTVLVGPT PANIIGRNLL TQIGCTLNF
Length:99
Mass (Da):10,724
Last modified:March 1, 2001 - v1
Checksum:i015539B069915479
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei99 – 991Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264323 Genomic RNA. Translation: AAG28668.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264323 Genomic RNA. Translation: AAG28668.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HB2 X-ray 2.30 A 1-99 [» ]
2HC0 X-ray 1.30 A/B 1-99 [» ]
ProteinModelPortali Q9E3M8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
Pfami PF00077. RVP. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen."
    Izopet J., Massip P., Souyris C., Sandres K., Puissant B., Obadia M., Pasquier C., Bonnet E., Marchou B., Puel J.
    AIDS 14:2247-2255(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure of HIV Protease 6X Mutant in complex with AB-2."
    Heaslet H., Brik A., Lin Y.-C., Elder J.H., Stout C.D.
    Submitted (JUN-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS).
  3. "Conformational flexibility in the flap domains of ligand-free HIV protease."
    Heaslet H., Rosenfeld R., Giffin M., Lin Y.C., Tam K., Torbett B.E., Elder J.H., McRee D.E., Stout C.D.
    Acta Crystallogr. D 63:866-875(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

Entry informationi

Entry nameiQ9E3M8_9HIV1
AccessioniPrimary (citable) accession number: Q9E3M8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3