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Q9DSN9

- POLN_ABPVR

UniProt

Q9DSN9 - POLN_ABPVR

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Protein
Replicase polyprotein
Gene
ORF1
Organism
Acute bee paralysis virus (strain Rothamsted) (ABPV)
Status
Reviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

Replicase polyprotein contains helicase, VPg, protease and RNA-directed RNA polymerase functions.
RNA-directed RNA polymerase replicates genomic and antigenomic RNA and transcribes the vial genome.
The protease generates mature viral proteins from the precursor polyprotein.
VPg is covalently linked to the 5'-end of genomic RNA.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi544 – 5518ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA helicase activity Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  5. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replicase polyprotein (EC:2.7.7.48, EC:3.4.22.-)
Gene namesi
ORF Names:ORF1
OrganismiAcute bee paralysis virus (strain Rothamsted) (ABPV)
Taxonomic identifieri1217067 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesDicistroviridaeAparavirus
Virus hostiApis mellifera (Honeybee) [TaxID: 7460]
ProteomesiUP000006040: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19061906Replicase polyprotein
PRO_0000423158Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo by the viral protease yield a variety of precursors and mature proteins Inferred.

Structurei

3D structure databases

ProteinModelPortaliQ9DSN9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini513 – 692180SF3 helicase
Add
BLAST
Domaini1638 – 1772135RdRp catalytic
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1124 – 1350227Protease
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 1574Poly-Leu
Compositional biasi337 – 3404Poly-Asn

Sequence similaritiesi

Family and domain databases

InterProiIPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR024387. Pept_C3G_Picornavir.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF12381. Peptidase_C3G. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DSN9-1 [UniParc]FASTAAdd to Basket

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MNFTKQPASL KYLSSMKLIT SQDQDFFNFG EVSREFILEQ AYVNGYDFHM     50
LHQDMNCIGF VLSIFDEDAR DEYEYKDLNC EYHENLFDAV VDSEFDKIWP 100
HLVLKYITYY PCSLNWRGMP TIPIVYVSKH FWYELYRTGF LNKLYHCGSW 150
TDILLLLSGD VETNPGPVET YKDLCRRKNI RKRKSRIREE IKMQQHIDKI 200
IGQENEEYKI INVNMQGIFS FNEEKEIIKS TAWKFNSTLD KTNSIIDNLI 250
PQLEETLAGF RKTYSKCESK IFGTISVVDV CVDLISALLQ VSFAKPAMKI 300
ASLAVEVFRL IKKYVSNINI NIDKIKELLS YGKVALNNNN PIIHVTMQSN 350
SPILEVLLQP NIIVSAIFIA LSVVFHKKFT YKKLGIEAMI KRLGDLGRAA 400
KGCSDLNVVL NQAITNHMLE HFGKNVLGLK QEDELKVLVE GYRNWCDEVR 450
DLVGHKINSD GELDSKSIVE NIMKDVYEIQ RIENMYKKGL EISRNIAELK 500
LPTKLTISFN THMRYLTEVF KSVDTSGAFG NKPRTQPIVI WLFGESGRGK 550
SGMTWPLAID LNNSLLDNVD EMRNFSKNIY MRNVEQEFWD NYQGQNIVCX 600
DDFGQMRDSS SNPNPEFMEL IRTANIAPYP LHMAHLEDKR KTKFTSKVII 650
MTSNVFEQDV NSLTFPDAFR RRVDLCAEVK NKDEFTKMCW SKSAGKMVQR 700
LDKGKVKKIT GDIHSTVPYI VDLIDPESGE VYKTGLEYEE FLDMCLEKTS 750
QCRDDSAKLN DFLMDYAEKR ANRSREIDEV CARTMDEAFV DAYDDVIDVN 800
MQIETVDEME LIEPNKLREM IEQCSNKIVY TYEGIAVKIT SLAFKLATLN 850
YEEQWEQIKE MKYYVKVSSG VNYLKRVLSQ GMKVCEEWMK EMINYVKEHP 900
WMTVSLILGT LIGILTVVGF WKWLCSGDKK KNPIKRHFIN TGNVLILPDR 950
ELNTFWKNQE SLDLRDMYIN RVEEHIISLL KLQHKVVLVP KVTKYILTTV 1000
ENHAKISDKI ILITRNRYLN YQGKFVELIC GEINQFFIDP ETLDTNVEAF 1050
ASADLKTFVQ RKPIVIEGPE FVEAQTSGDQ ITLRKQTQKV IEAFASSDAI 1100
TMARKTPKFV ESDDVVEVSM QMWKDQVAQK LITNRVLTNL YKICLVKENG 1150
DMVPLLNGLF VRSNIMLAPG HLVGFLSDSD TIEIRNLFDV VFRVPWKDVK 1200
KVDVVNAFGE SKEAVLLCFP KFVCQHTDLV KHFQDSESMS KFKRCEVTLP 1250
VLRYSDKMNR FLATLIECDK VEAYDRPYTL NDSSKGQYIL RQGLEYTMPT 1300
TNGDCGAPLV INETQVIRKI AGIHVAGDAR GKAYAESISQ KDLIRAFSKI 1350
DVSMQIQLDL DQTLNFNQQQ XIIPPNAEFG PEDLDFCDLP SLKMIPVGRL 1400
SEPLFEPGKT DIRPSLVYGK ISEIKTKPAI LRNVIVDGKI VNIKHKNLKK 1450
CAMDTPYVSK EMTEEAFQLV KSVWLKGMRN ELKKVLTYEE AICGNDSSEF 1500
ISAINRSSSP GFPWIRDRIK GTKGKQGWFG AEGEYILDED VFEAVKTRIQ 1550
NAKNGVRTPV MWVDTLKDER RPIEKVDQLK TRVFSNGPMD FSITFRMYYL 1600
GFIAHLMENR ITNEVSIGTN VYSQDWNKTV RKLKTMGPKV IAGDFSTFDG 1650
SLNVCIMEKF ADLANEFYDD GSENALIRHV LLMDVYNSTH ICGDSVYMMT 1700
HSQPSGNPAT TPLNCFINSM GLRMVFELCS KKYSALNGTK CYVMKDFSKH 1750
VSIVSYGDDN VINFSDEVSE WFNMETITEA FEKLGFTYTD ELKGKNGEVP 1800
KWRTIEDVQY LKRKFRYDSK RKVWEAPLCM DTILEMPNWC RGSLDIQEGT 1850
KVNCENAIME LSMHEEYVFD KWSKVISKAY QKATGDCLDI STYNGYAQER 1900
FLNYYL 1906
Length:1,906
Mass (Da):219,430
Last modified:March 1, 2001 - v1
Checksum:i5A48F79063235FE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF150629 Genomic RNA. Translation: AAG13118.1.
RefSeqiNP_066241.1. NC_002548.1.

Genome annotation databases

GeneIDi911837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF150629 Genomic RNA. Translation: AAG13118.1 .
RefSeqi NP_066241.1. NC_002548.1.

3D structure databases

ProteinModelPortali Q9DSN9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911837.

Family and domain databases

InterProi IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR024387. Pept_C3G_Picornavir.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF12381. Peptidase_C3G. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the complete genome sequence of acute bee paralysis virus shows that it belongs to the novel group of insect-infecting RNA viruses."
    Govan V.A., Leat N., Allsopp M., Davison S.
    Virology 277:457-463(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPOLN_ABPVR
AccessioniPrimary (citable) accession number: Q9DSN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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