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Q9DSN8 (POLS_ABPVR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Structural polyprotein

Cleaved into the following 4 chains:

  1. Protein VP1
    Alternative name(s):
    Virion protein 2
  2. Protein VP4
    Alternative name(s):
    Virion protein 4
  3. Protein VP2
    Alternative name(s):
    Virion protein 3
  4. Protein VP3
    Alternative name(s):
    Virion protein 1
Gene names
ORF Names:ORF2
OrganismAcute bee paralysis virus (strain Rothamsted) (ABPV) [Reference proteome]
Taxonomic identifier1217067 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesDicistroviridaeAparavirus
Virus hostApis mellifera (Honeybee) [TaxID: 7460]

Protein attributes

Sequence length904 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural polyprotein: precursor of all the viral capsid proteins.

Protein VP1: Forms, together with protein VP2 and protein VP3, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.

Protein VP2: Forms, together with protein VP1 and protein VP3, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.

Protein VP3: Forms, together with protein VP1 and protein VP2, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.

Subcellular location

Protein VP1: Virion. Host cytoplasm Potential.

Protein VP2: Virion. Host cytoplasm Potential.

Protein VP3: Virion. Host cytoplasm Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins.

Sequence similarities

Belongs to the picornaviruses polyprotein family.

Caution

Translation initiates on an Ala codon through an unusual Internal Ribosome Entry Site (IRES).

Sequence caution

The sequence AAG13119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCapsid protein
Host cytoplasm
Virion
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Protein VP1 Potential
PRO_0000423154
Chain315 – 39682Protein VP4 Potential
PRO_0000423155
Chain397 – 696300Protein VP2 Potential
PRO_0000423156
Chain697 – 904208Protein VP3 Potential
PRO_0000423157

Regions

Compositional bias662 – 6654Poly-Val

Sequences

Sequence LengthMass (Da)Tools
Q9DSN8 [UniParc].

Last modified July 24, 2013. Version 2.
Checksum: F9AA1FF575432CCE

FASTA904100,879
        10         20         30         40         50         60 
ADQETNTSNV HNTQLASTSE ENSVETEQIT TFHDVETPNR INTPMAQDTS SARSMDDTHS 

        70         80         90        100        110        120 
IIQFLQRPVL IDHIEVIAGS TADDNKPLNR YVLNRQNPQP FVKSWTLPSV VLSAGGKGQK 

       130        140        150        160        170        180 
LANFKYLRCD VKVKIVLNAN PFIAGRLYLA YSPYDDRVDP ARSILNTSRA GVTGYPGIEI 

       190        200        210        220        230        240 
DFQLDNSVEM TIPYASFQEA YDLVTGTEDF VKLYLFTITP ILSPTSTSAS SKVDLSVYMW 

       250        260        270        280        290        300 
LDNISLVIPT YRVNTSIVPN VGTVVQTVQN MTTRDSETIR KAMVALRKNN KSTYDYIVQA 

       310        320        330        340        350        360 
LSSAVPEVKN VTMQINSKKN NSNKMATPVK EKTKNIPKPK TENPKIGPIS ELATGVNKVA 

       370        380        390        400        410        420 
NGIERIPVIG EMAKPVTSTI KWVADKIGSV AAIFGWSKPR NLEQVNLYQN VPGWGYSLYK 

       430        440        450        460        470        480 
GIDNSVPLAF DPNNELGDLR DVFPSGVDEM AIGYVCGNPA VKHVLSWNTT DKVQAPISNG 

       490        500        510        520        530        540 
DDWGGVIPVG MPCYSKIIRT TENDTTRTNT EIMDPAPCEY VCNMFSYWRA TMCYRIAIVK 

       550        560        570        580        590        600 
TAFHTGRLGI FFGPGKIPIT TTKDNISPDL TQLDGIKAPS DNNYKYILDL TNDTEITIRV 

       610        620        630        640        650        660 
PFVSNKMFMK STGIYGGNSE NNWDFSESFT GFLCIRPITK FMCPETVSNN VSIVVWKWAE 

       670        680        690        700        710        720 
DVVVVEPKPL LSGPTQVFQP PVTSADSINT IDASMQINLA NKADENVVTF FDSDDAEERN 

       730        740        750        760        770        780 
MEALLKGSGE QIMNLRSLLR TFRTISENWN LPPNTKTAIT DLTDVADKEG RDYMSYLSYI 

       790        800        810        820        830        840 
YRFYRGGRRY KFFNTTALKQ SQTCYVRSFL IPRYYTADNT NNDGPSHITY PVLNPVHEVE 

       850        860        870        880        890        900 
VPYYCQYRKL PVASTTDKGY DASLMYYSNV GTNQIVARAG NDDFTFGWLI GTPQTQGITR 


TETK 

« Hide

References

[1]"Analysis of the complete genome sequence of acute bee paralysis virus shows that it belongs to the novel group of insect-infecting RNA viruses."
Govan V.A., Leat N., Allsopp M., Davison S.
Virology 277:457-463(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Infection of honey bees with acute bee paralysis virus does not trigger humoral or cellular immune responses."
Azzami K., Ritter W., Tautz J., Beier H.
Arch. Virol. 157:689-702(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF150629 Genomic RNA. Translation: AAG13119.1. Different initiation.
RefSeqNP_066242.1. NC_002548.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911836.

Family and domain databases

Gene3D2.60.120.20. 3 hits.
InterProIPR014872. Dicistrovirus_capsid-polyPr_C.
IPR001676. Picornavirus_capsid.
IPR029053. Viral_coat.
IPR024343. VP4_dicistrovir.
[Graphical view]
PfamPF08762. CRPV_capsid. 1 hit.
PF11492. Dicistro_VP4. 1 hit.
PF00073. Rhv. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOLS_ABPVR
AccessionPrimary (citable) accession number: Q9DSN8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: July 24, 2013
Last modified: July 9, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families