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Q9DSN8

- POLS_ABPVR

UniProt

Q9DSN8 - POLS_ABPVR

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Protein

Structural polyprotein

Gene

ORF2

Organism
Acute bee paralysis virus (strain Rothamsted) (ABPV)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Structural polyprotein: precursor of all the viral capsid proteins.
Protein VP1: Forms, together with protein VP2 and protein VP3, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.
Protein VP2: Forms, together with protein VP1 and protein VP3, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.
Protein VP3: Forms, together with protein VP1 and protein VP2, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Structural polyprotein
Cleaved into the following 4 chains:
Alternative name(s):
Virion protein 2
Alternative name(s):
Virion protein 4
Alternative name(s):
Virion protein 3
Alternative name(s):
Virion protein 1
Gene namesi
ORF Names:ORF2
OrganismiAcute bee paralysis virus (strain Rothamsted) (ABPV)
Taxonomic identifieri1217067 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesDicistroviridaeAparavirus
Virus hostiApis mellifera (Honeybee) [TaxID: 7460]
ProteomesiUP000006040: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Protein VP1Sequence AnalysisPRO_0000423154Add
BLAST
Chaini315 – 39682Protein VP4Sequence AnalysisPRO_0000423155Add
BLAST
Chaini397 – 696300Protein VP2Sequence AnalysisPRO_0000423156Add
BLAST
Chaini697 – 904208Protein VP3Sequence AnalysisPRO_0000423157Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi662 – 6654Poly-Val

Sequence similaritiesi

Belongs to the picornaviruses polyprotein family.Curated

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
InterProiIPR014872. Dicistrovirus_capsid-polyPr_C.
IPR001676. Picornavirus_capsid.
IPR029053. Viral_coat.
IPR024343. VP4_dicistrovir.
[Graphical view]
PfamiPF08762. CRPV_capsid. 1 hit.
PF11492. Dicistro_VP4. 1 hit.
PF00073. Rhv. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DSN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ADQETNTSNV HNTQLASTSE ENSVETEQIT TFHDVETPNR INTPMAQDTS
60 70 80 90 100
SARSMDDTHS IIQFLQRPVL IDHIEVIAGS TADDNKPLNR YVLNRQNPQP
110 120 130 140 150
FVKSWTLPSV VLSAGGKGQK LANFKYLRCD VKVKIVLNAN PFIAGRLYLA
160 170 180 190 200
YSPYDDRVDP ARSILNTSRA GVTGYPGIEI DFQLDNSVEM TIPYASFQEA
210 220 230 240 250
YDLVTGTEDF VKLYLFTITP ILSPTSTSAS SKVDLSVYMW LDNISLVIPT
260 270 280 290 300
YRVNTSIVPN VGTVVQTVQN MTTRDSETIR KAMVALRKNN KSTYDYIVQA
310 320 330 340 350
LSSAVPEVKN VTMQINSKKN NSNKMATPVK EKTKNIPKPK TENPKIGPIS
360 370 380 390 400
ELATGVNKVA NGIERIPVIG EMAKPVTSTI KWVADKIGSV AAIFGWSKPR
410 420 430 440 450
NLEQVNLYQN VPGWGYSLYK GIDNSVPLAF DPNNELGDLR DVFPSGVDEM
460 470 480 490 500
AIGYVCGNPA VKHVLSWNTT DKVQAPISNG DDWGGVIPVG MPCYSKIIRT
510 520 530 540 550
TENDTTRTNT EIMDPAPCEY VCNMFSYWRA TMCYRIAIVK TAFHTGRLGI
560 570 580 590 600
FFGPGKIPIT TTKDNISPDL TQLDGIKAPS DNNYKYILDL TNDTEITIRV
610 620 630 640 650
PFVSNKMFMK STGIYGGNSE NNWDFSESFT GFLCIRPITK FMCPETVSNN
660 670 680 690 700
VSIVVWKWAE DVVVVEPKPL LSGPTQVFQP PVTSADSINT IDASMQINLA
710 720 730 740 750
NKADENVVTF FDSDDAEERN MEALLKGSGE QIMNLRSLLR TFRTISENWN
760 770 780 790 800
LPPNTKTAIT DLTDVADKEG RDYMSYLSYI YRFYRGGRRY KFFNTTALKQ
810 820 830 840 850
SQTCYVRSFL IPRYYTADNT NNDGPSHITY PVLNPVHEVE VPYYCQYRKL
860 870 880 890 900
PVASTTDKGY DASLMYYSNV GTNQIVARAG NDDFTFGWLI GTPQTQGITR

TETK
Length:904
Mass (Da):100,879
Last modified:July 24, 2013 - v2
Checksum:iF9AA1FF575432CCE
GO

Sequence cautioni

The sequence AAG13119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF150629 Genomic RNA. Translation: AAG13119.1. Different initiation.
RefSeqiNP_066242.1. NC_002548.1.

Genome annotation databases

GeneIDi911836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF150629 Genomic RNA. Translation: AAG13119.1 . Different initiation.
RefSeqi NP_066242.1. NC_002548.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911836.

Family and domain databases

Gene3Di 2.60.120.20. 3 hits.
InterProi IPR014872. Dicistrovirus_capsid-polyPr_C.
IPR001676. Picornavirus_capsid.
IPR029053. Viral_coat.
IPR024343. VP4_dicistrovir.
[Graphical view ]
Pfami PF08762. CRPV_capsid. 1 hit.
PF11492. Dicistro_VP4. 1 hit.
PF00073. Rhv. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the complete genome sequence of acute bee paralysis virus shows that it belongs to the novel group of insect-infecting RNA viruses."
    Govan V.A., Leat N., Allsopp M., Davison S.
    Virology 277:457-463(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Infection of honey bees with acute bee paralysis virus does not trigger humoral or cellular immune responses."
    Azzami K., Ritter W., Tautz J., Beier H.
    Arch. Virol. 157:689-702(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

Entry informationi

Entry nameiPOLS_ABPVR
AccessioniPrimary (citable) accession number: Q9DSN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: July 24, 2013
Last modified: October 29, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Translation initiates on an Ala codon through an unusual Internal Ribosome Entry Site (IRES).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3