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Q9DSN8

- POLS_ABPVR

UniProt

Q9DSN8 - POLS_ABPVR

Protein

Structural polyprotein

Gene

ORF2

Organism
Acute bee paralysis virus (strain Rothamsted) (ABPV)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (24 Jul 2013)
      Previous versions | rss
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    Functioni

    Structural polyprotein: precursor of all the viral capsid proteins.
    Protein VP1: Forms, together with protein VP2 and protein VP3, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.
    Protein VP2: Forms, together with protein VP1 and protein VP3, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.
    Protein VP3: Forms, together with protein VP1 and protein VP2, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Structural polyprotein
    Cleaved into the following 4 chains:
    Alternative name(s):
    Virion protein 2
    Alternative name(s):
    Virion protein 4
    Alternative name(s):
    Virion protein 3
    Alternative name(s):
    Virion protein 1
    Gene namesi
    ORF Names:ORF2
    OrganismiAcute bee paralysis virus (strain Rothamsted) (ABPV)
    Taxonomic identifieri1217067 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesDicistroviridaeAparavirus
    Virus hostiApis mellifera (Honeybee) [TaxID: 7460]
    ProteomesiUP000006040: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Protein VP1Sequence AnalysisPRO_0000423154Add
    BLAST
    Chaini315 – 39682Protein VP4Sequence AnalysisPRO_0000423155Add
    BLAST
    Chaini397 – 696300Protein VP2Sequence AnalysisPRO_0000423156Add
    BLAST
    Chaini697 – 904208Protein VP3Sequence AnalysisPRO_0000423157Add
    BLAST

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins.1 Publication

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi662 – 6654Poly-Val

    Sequence similaritiesi

    Belongs to the picornaviruses polyprotein family.Curated

    Family and domain databases

    Gene3Di2.60.120.20. 3 hits.
    InterProiIPR014872. Dicistrovirus_capsid-polyPr_C.
    IPR001676. Picornavirus_capsid.
    IPR029053. Viral_coat.
    IPR024343. VP4_dicistrovir.
    [Graphical view]
    PfamiPF08762. CRPV_capsid. 1 hit.
    PF11492. Dicistro_VP4. 1 hit.
    PF00073. Rhv. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DSN8-1 [UniParc]FASTAAdd to Basket

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    ADQETNTSNV HNTQLASTSE ENSVETEQIT TFHDVETPNR INTPMAQDTS    50
    SARSMDDTHS IIQFLQRPVL IDHIEVIAGS TADDNKPLNR YVLNRQNPQP 100
    FVKSWTLPSV VLSAGGKGQK LANFKYLRCD VKVKIVLNAN PFIAGRLYLA 150
    YSPYDDRVDP ARSILNTSRA GVTGYPGIEI DFQLDNSVEM TIPYASFQEA 200
    YDLVTGTEDF VKLYLFTITP ILSPTSTSAS SKVDLSVYMW LDNISLVIPT 250
    YRVNTSIVPN VGTVVQTVQN MTTRDSETIR KAMVALRKNN KSTYDYIVQA 300
    LSSAVPEVKN VTMQINSKKN NSNKMATPVK EKTKNIPKPK TENPKIGPIS 350
    ELATGVNKVA NGIERIPVIG EMAKPVTSTI KWVADKIGSV AAIFGWSKPR 400
    NLEQVNLYQN VPGWGYSLYK GIDNSVPLAF DPNNELGDLR DVFPSGVDEM 450
    AIGYVCGNPA VKHVLSWNTT DKVQAPISNG DDWGGVIPVG MPCYSKIIRT 500
    TENDTTRTNT EIMDPAPCEY VCNMFSYWRA TMCYRIAIVK TAFHTGRLGI 550
    FFGPGKIPIT TTKDNISPDL TQLDGIKAPS DNNYKYILDL TNDTEITIRV 600
    PFVSNKMFMK STGIYGGNSE NNWDFSESFT GFLCIRPITK FMCPETVSNN 650
    VSIVVWKWAE DVVVVEPKPL LSGPTQVFQP PVTSADSINT IDASMQINLA 700
    NKADENVVTF FDSDDAEERN MEALLKGSGE QIMNLRSLLR TFRTISENWN 750
    LPPNTKTAIT DLTDVADKEG RDYMSYLSYI YRFYRGGRRY KFFNTTALKQ 800
    SQTCYVRSFL IPRYYTADNT NNDGPSHITY PVLNPVHEVE VPYYCQYRKL 850
    PVASTTDKGY DASLMYYSNV GTNQIVARAG NDDFTFGWLI GTPQTQGITR 900
    TETK 904
    Length:904
    Mass (Da):100,879
    Last modified:July 24, 2013 - v2
    Checksum:iF9AA1FF575432CCE
    GO

    Sequence cautioni

    The sequence AAG13119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF150629 Genomic RNA. Translation: AAG13119.1. Different initiation.
    RefSeqiNP_066242.1. NC_002548.1.

    Genome annotation databases

    GeneIDi911836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF150629 Genomic RNA. Translation: AAG13119.1 . Different initiation.
    RefSeqi NP_066242.1. NC_002548.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 911836.

    Family and domain databases

    Gene3Di 2.60.120.20. 3 hits.
    InterProi IPR014872. Dicistrovirus_capsid-polyPr_C.
    IPR001676. Picornavirus_capsid.
    IPR029053. Viral_coat.
    IPR024343. VP4_dicistrovir.
    [Graphical view ]
    Pfami PF08762. CRPV_capsid. 1 hit.
    PF11492. Dicistro_VP4. 1 hit.
    PF00073. Rhv. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the complete genome sequence of acute bee paralysis virus shows that it belongs to the novel group of insect-infecting RNA viruses."
      Govan V.A., Leat N., Allsopp M., Davison S.
      Virology 277:457-463(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Infection of honey bees with acute bee paralysis virus does not trigger humoral or cellular immune responses."
      Azzami K., Ritter W., Tautz J., Beier H.
      Arch. Virol. 157:689-702(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

    Entry informationi

    Entry nameiPOLS_ABPVR
    AccessioniPrimary (citable) accession number: Q9DSN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2013
    Last sequence update: July 24, 2013
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Caution

    Translation initiates on an Ala codon through an unusual Internal Ribosome Entry Site (IRES).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3