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Protein

Protein Nef

Gene

nef

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasionUniRule annotation, VirulenceUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NefUniRule annotationSAAS annotation
Gene namesi
Name:nefImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Lipid-anchor SAAS annotation; Cytoplasmic side SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane

PTM / Processingi

Keywords - PTMi

Lipoprotein, MyristateUniRule annotation

Interactioni

Subunit structurei

Homodimer.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ9DQV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lentivirus primate group Nef protein family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.62.10. 1 hit.
4.10.890.10. 1 hit.
InterProiView protein in InterPro
IPR027480. HIV-1_Nef_anchor.
IPR027481. HIV-1_Nef_core_sf.
IPR001558. HIV_Nef.
PfamiView protein in Pfam
PF00469. F-protein. 1 hit.
SUPFAMiSSF55671. SSF55671. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9DQV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGGKWSKRSV VGWPAVRERM KRAEPAAAEP AADGVGAVSR DLEKHGAITS
60 70 80 90 100
SNTNNADCAW LEAQEEEEVG FPVRPQVPLR PMTYKAALDL SHFLKEKGGL
110 120 130 140 150
EGIIHSQKRQ DILDLWIYHT QGYFPDWQNY TPGPGIRYPL TFGWCFKLVP
160 170 180 190 200
VQPEQVEEAN EGENNSLLHP KSLHGMVDKE REVLVWRFDS RLAFHHMARE

LHPEYYKDC
Length:209
Mass (Da):23,821
Last modified:March 1, 2001 - v1
Checksum:i34AFA9492949A6AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252897 Genomic DNA. Translation: AAG34569.1.

Similar proteinsi

Entry informationi

Entry nameiQ9DQV2_9HIV1
AccessioniPrimary (citable) accession number: Q9DQV2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)