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Q9DLP3 (Q9DLP3_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Hemagglutinin EMBL AAG38534.1
OrganismInfluenza A virus (A/duck/Malaysia/F119-3/97(H5N3)) EMBL AAG38534.1
Taxonomic identifier144182 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity. RuleBase RU003324 SAAS SAAS013828

Subunit structure

Homotrimer of disulfide-linked HA1-HA2 By similarity. RuleBase RU003324 SAAS SAAS013828

Sequence similarities

Belongs to the influenza viruses hemagglutinin family. RuleBase RU003324

Sequences

Sequence LengthMass (Da)Tools
Q9DLP3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 2A9C15F31C8F987E

FASTA56463,468
        10         20         30         40         50         60 
MEKIVLLLAI VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE KTHNGKLCSL 

        70         80         90        100        110        120 
NGVKPLILRD CSVAGWLLGN PMCDEFLNVP EWSYIVEKDN PVNGLCYPGD FNDYEELKHL 

       130        140        150        160        170        180 
LSSTNHFEKI RIIPRSSWSN HDASSGVSSA CPYNGRSSFF RNVVWLIKKN NAYPTIKRSY 

       190        200        210        220        230        240 
NNTNQEDLLI LWGIHHPNDA AEQTKLYQNP TTYVSVGTST LNQRSVPEIA TRPKVNGQSG 

       250        260        270        280        290        300 
RMEFFWTILK PNDAINFESN GNFIAPEYAY KIVKKGGSAI MKSGLEYGNC NTKCQTPMGA 

       310        320        330        340        350        360 
INSSMPFHNI HPLTIGECPK YVKSGRLVLA TGLRNVPQRE TRGLFGAIAG FIEGGWQGMV 

       370        380        390        400        410        420 
DGWYGYHHSN EQGSGYAADK ESTQKAIDGI TNKVNSIIDK MNTQFEAVGK EFNNLERRIE 

       430        440        450        460        470        480 
NLNKKMEDGF LDVWTYNAEL LVLMENERTL DFHDSNVKNL YDKVRLQLRD NAKELGNGCF 

       490        500        510        520        530        540 
EFYHKCDNEC MESVKNGTYD YPQYSEEARL NREEISGVKL ESMGIYQILS IYSTVASSLA 

       550        560 
LAIMIAGLSF WMCSNGSLQC RICI

« Hide

References

[1]"Phylogenetic analysis of H5 subtype viruses."
Banks J.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/duck/Malaysia/F119-3/97 EMBL AAG38534.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF303057 mRNA. Translation: AAG38534.1.

3D structure databases

ProteinModelPortalQ9DLP3.
SMRQ9DLP3. Positions 17-337, 343-516.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
Gene3DG3DSA:3.90.209.20. Haemagglutn_HA1_a/b. 1 hit.
G3DSA:2.10.77.10. Haemagglutn_HA1_b-ribbon. 1 hit.
G3DSA:3.90.20.10. Haemagglutn_stalk. 1 hit.
PfamPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMSSF49818. Capsid_hemag. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9DLP3_9INFA
AccessionPrimary (citable) accession number: Q9DLP3
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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