Unreviewed, UniProtKB/TrEMBL Q9DLP3 (Q9DLP3_9INFA)

Names and origin

Protein names	Submitted name:     Hemagglutinin EMBL AAG38534.1
Organism	Influenza A virus (A/duck/Malaysia/F119-3/97(H5N3)) EMBL AAG38534.1
Taxonomic identifier	144182 [NCBI]
Taxonomic lineage	Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity. RuleBase RU003324V0 Spearmint SPM013827
Subunit structure	Homotrimer of disulfide-linked HA1-HA2 By similarity. RuleBase RU003324V0 Spearmint SPM013827
Subcellular location	Virion membrane; Single-pass type I membrane protein Potential. Host apical cell membrane; Single-pass type I membrane protein Spearmint SPM013827.
Sequence similarities	Belongs to the influenza viruses hemagglutinin family.

Ontologies

Keywords
Biological process	Fusion protein Spearmint SPM013827
Cellular component	Envelope protein RuleBase RU003324V0 Spearmint SPM013827 Host cell membrane Spearmint SPM013827 Host membrane Membrane Virion
Domain	Transmembrane Spearmint SPM013827
Molecular function	Hemagglutinin RuleBase RU003324V0 Spearmint SPM013827
Gene Ontology (GO)
Biological process	viral envelope fusion with host membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	host cell surface receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9DLP3-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 2A9C15F31C8F987E	FASTA	564	63,468
	10 20 30 40 50 60 MEKIVLLLAI VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE KTHNGKLCSL 70 80 90 100 110 120 NGVKPLILRD CSVAGWLLGN PMCDEFLNVP EWSYIVEKDN PVNGLCYPGD FNDYEELKHL 130 140 150 160 170 180 LSSTNHFEKI RIIPRSSWSN HDASSGVSSA CPYNGRSSFF RNVVWLIKKN NAYPTIKRSY 190 200 210 220 230 240 NNTNQEDLLI LWGIHHPNDA AEQTKLYQNP TTYVSVGTST LNQRSVPEIA TRPKVNGQSG 250 260 270 280 290 300 RMEFFWTILK PNDAINFESN GNFIAPEYAY KIVKKGGSAI MKSGLEYGNC NTKCQTPMGA 310 320 330 340 350 360 INSSMPFHNI HPLTIGECPK YVKSGRLVLA TGLRNVPQRE TRGLFGAIAG FIEGGWQGMV 370 380 390 400 410 420 DGWYGYHHSN EQGSGYAADK ESTQKAIDGI TNKVNSIIDK MNTQFEAVGK EFNNLERRIE 430 440 450 460 470 480 NLNKKMEDGF LDVWTYNAEL LVLMENERTL DFHDSNVKNL YDKVRLQLRD NAKELGNGCF 490 500 510 520 530 540 EFYHKCDNEC MESVKNGTYD YPQYSEEARL NREEISGVKL ESMGIYQILS IYSTVASSLA 550 560 LAIMIAGLSF WMCSNGSLQC RICI

References

[1]	"Phylogenetic analysis of H5 subtype viruses." Banks J. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A/duck/Malaysia/F119-3/97 EMBL AAG38534.1.
[2]	"X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs." Ha Y., Stevens D.J., Skehel J.J., Wiley D.C. Proc. Natl. Acad. Sci. U.S.A. 98:11181-11186(2001) [PubMed: 11562490] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 17-341.
[3]	"H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes." Ha Y., Stevens D.J., Skehel J.J., Wiley D.C. EMBO J. 21:865-875(2002) [PubMed: 11867515] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 17-341.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303057 mRNA. Translation: AAG38534.1.
3D structure databases
SMR	Q9DLP3. Positions 17-337, 343-516.
ModBase	Search...
Family and domain databases
InterPro	IPR008980. Capsid_hemagglutn. IPR013827. Hemagglutn_HA1_b-rbn_dom. IPR000149. Hemagglutn_influenz_HA1. IPR001364. Hemagglutn_influenz_HA1/HA2. IPR013829. Hemagglutn_stalk. [Graphical view]
Gene3D	G3DSA:2.10.77.10. Haemagglutn_HA1_b-ribbon. 1 hit. G3DSA:3.90.20.10. Haemagglutn_stalk. 1 hit.
Pfam	PF00509. Hemagglutinin. 1 hit. [Graphical view]
PRINTS	PR00330. HEMAGGLUTN1. PR00329. HEMAGGLUTN12.
ProtoNet	Search...

Entry information

Entry name

Q9DLP3_9INFA

Accession

Primary (citable) accession number: Q9DLP3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)