Q9DIC5 (RDRP_AHNNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: RNA-directed RNA polymerase Short name=RdRp EC=2.7.7.48 Alternative name(s): RNA replicase Short name=Protein A
Organism	Atlantic halibut nervous necrosis virus (AhNNV)
Taxonomic identifier	99486 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nodaviridae › Betanodavirus › unclassified Betanodavirus
Virus host	Hippoglossus hippoglossus (Atlantic halibut) (Pleuronectes hippoglossus) [TaxID: 8267]

Protein attributes

Sequence length	981 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the nodaviridae RNA polymerase family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	Viral RNA replication
Ligand	Nucleotide-binding
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 981	981	RNA-directed RNA polymerase		PRO_0000222443
Regions
	Domain	579 – 701	123	RdRp catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q9DIC5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6587D72D676FEA50	FASTA	981	110,328
	10 20 30 40 50 60 MRSYEFHLAR MSGATLCVVT GYRLLTSKWL ADRIEDYRQR VIADRKKIIR DAAMIRTSVQ 70 80 90 100 110 120 KQMELVRISV RKGHSHQEAA TERNSATETM LSVVEKSGYE PYIISPSPRE AEYHGSRQFY 130 140 150 160 170 180 SLADFRQDYR RDEITDRHII VMTDVDYYVD MNELIGLGVP VLMYTFQPST VSGEVKDGYF 190 200 210 220 230 240 TITDDSVHYR VAGGKDVRHR IWNYNQDTMY TVSRPTGFWE NLKRILRDIT GITALCGFLY 250 260 270 280 290 300 NKLGMAPFGD PVTMFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LEYMRYQQRN 310 320 330 340 350 360 NIANFNAVTY ISEEGPLISL GLEGNFASVQ LPLQDFENVR TAYELSKTNN LSDTVRRSGR 370 380 390 400 410 420 PCKEAAIIHK CLQAECVLAS EVVHKPGDLA RHYQAVGSLY DVDPAEQGKC YAREYAPGPL 430 440 450 460 470 480 TQTAVFPNES RSNERATIDG RIAGPQAKAK SREHITPRMR KVARDFVRHL VPEAGLGRPY 490 500 510 520 530 540 PLTYVEEQQS KPLQRARNDA NRYHDEFTMI VKAFQKKEAY NAPNYPRNIS TVPHNQNVKL 550 560 570 580 590 600 SSYTYAFKAS TLQHVPWYMP THTPAEIADA VQNLAASTTE LVETDYSKFD GTFLRFMREC 610 620 630 640 650 660 VEFAIYKRWV HLDHLAELSQ LLANELQAPA VTRLGLKYDP DCSRLSGSAL TTDGNSIANA 670 680 690 700 710 720 FVSYLANRLA GMDDDEAWSW IGIVYGDDGL RSGNVSDTLL TDTASSLGFD LKIVNRAPRG 730 740 750 760 770 780 SPVTFLARVY LDPWSSPASV QSPFRTLLKL HTTCDTQSEI EDIGWAKTQA YLVTDCKTPF 790 800 810 820 830 840 IGHWCRAYQR NCTARVVQYA DYNDIPFWVK NDDHLGNSWP QSDSVDWNDV VANELGLTTA 850 860 870 880 890 900 ELLKHIALLE AYTGPTSGLP RLTTSIDLEP KMSVALDGEV QAGPSQQQTD KDGTNPTGDR 910 920 930 940 950 960 SAPRRARTAL PGVDGHTRCT RRSDRGPGER DANVRDKRPR RSMPPSRSVS SVPPPSSSGG 970 980 GADGDRVEGA ARPRRQRRTP V

References

[1]	"The sequence of RNA1 from Atlantic halibut nervous necrosis virus (AHNNV)." Sommerset I., Nerland A.H. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: AH99NorA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ401165 Genomic RNA. Translation: CAC17792.1.
3D structure databases
ProteinModelPortal	Q9DIC5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR007094. RNA-dir_pol_PSvirus. IPR001788. Tymovirus_RNA-dep_RNA_pol. [Graphical view]
Pfam	PF00978. RdRP_2. 1 hit. [Graphical view]
PROSITE	PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RDRP_AHNNV

Accession

Primary (citable) accession number: Q9DIC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	March 1, 2001
Last modified:	July 11, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program