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Q9DIC5

- RDRP_AHNNV

UniProt

Q9DIC5 - RDRP_AHNNV

Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Atlantic halibut nervous necrosis virus (AhNNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    RdRp
    Alternative name(s):
    RNA replicase
    Short name:
    Protein A
    OrganismiAtlantic halibut nervous necrosis virus (AhNNV)
    Taxonomic identifieri99486 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
    Virus hostiHippoglossus hippoglossus (Atlantic halibut) (Pleuronectes hippoglossus) [TaxID: 8267]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 981981RNA-directed RNA polymerasePRO_0000222443Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DIC5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini579 – 701123RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nodaviridae RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR001788. Tymovirus_RNA-dep_RNA_pol.
    [Graphical view]
    PfamiPF00978. RdRP_2. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DIC5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSYEFHLAR MSGATLCVVT GYRLLTSKWL ADRIEDYRQR VIADRKKIIR    50
    DAAMIRTSVQ KQMELVRISV RKGHSHQEAA TERNSATETM LSVVEKSGYE 100
    PYIISPSPRE AEYHGSRQFY SLADFRQDYR RDEITDRHII VMTDVDYYVD 150
    MNELIGLGVP VLMYTFQPST VSGEVKDGYF TITDDSVHYR VAGGKDVRHR 200
    IWNYNQDTMY TVSRPTGFWE NLKRILRDIT GITALCGFLY NKLGMAPFGD 250
    PVTMFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LEYMRYQQRN 300
    NIANFNAVTY ISEEGPLISL GLEGNFASVQ LPLQDFENVR TAYELSKTNN 350
    LSDTVRRSGR PCKEAAIIHK CLQAECVLAS EVVHKPGDLA RHYQAVGSLY 400
    DVDPAEQGKC YAREYAPGPL TQTAVFPNES RSNERATIDG RIAGPQAKAK 450
    SREHITPRMR KVARDFVRHL VPEAGLGRPY PLTYVEEQQS KPLQRARNDA 500
    NRYHDEFTMI VKAFQKKEAY NAPNYPRNIS TVPHNQNVKL SSYTYAFKAS 550
    TLQHVPWYMP THTPAEIADA VQNLAASTTE LVETDYSKFD GTFLRFMREC 600
    VEFAIYKRWV HLDHLAELSQ LLANELQAPA VTRLGLKYDP DCSRLSGSAL 650
    TTDGNSIANA FVSYLANRLA GMDDDEAWSW IGIVYGDDGL RSGNVSDTLL 700
    TDTASSLGFD LKIVNRAPRG SPVTFLARVY LDPWSSPASV QSPFRTLLKL 750
    HTTCDTQSEI EDIGWAKTQA YLVTDCKTPF IGHWCRAYQR NCTARVVQYA 800
    DYNDIPFWVK NDDHLGNSWP QSDSVDWNDV VANELGLTTA ELLKHIALLE 850
    AYTGPTSGLP RLTTSIDLEP KMSVALDGEV QAGPSQQQTD KDGTNPTGDR 900
    SAPRRARTAL PGVDGHTRCT RRSDRGPGER DANVRDKRPR RSMPPSRSVS 950
    SVPPPSSSGG GADGDRVEGA ARPRRQRRTP V 981
    Length:981
    Mass (Da):110,328
    Last modified:March 1, 2001 - v1
    Checksum:i6587D72D676FEA50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ401165 Genomic RNA. Translation: CAC17792.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ401165 Genomic RNA. Translation: CAC17792.1 .

    3D structure databases

    ProteinModelPortali Q9DIC5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR001788. Tymovirus_RNA-dep_RNA_pol.
    [Graphical view ]
    Pfami PF00978. RdRP_2. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of RNA1 from Atlantic halibut nervous necrosis virus (AHNNV)."
      Sommerset I., Nerland A.H.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: AH99NorA.

    Entry informationi

    Entry nameiRDRP_AHNNV
    AccessioniPrimary (citable) accession number: Q9DIC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3