Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9DHU2 (RIR2_YLDV) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Ordered Locus Names:20L
OrganismYaba-like disease virus (YLDV)
Taxonomic identifier132475 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Simiiformes [TaxID: 314293]

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Ribonucleoside-diphosphate reductase small chain
PRO_0000190501

Sites

Active site1121 By similarity
Metal binding741Iron 1 By similarity
Metal binding1051Iron 1 By similarity
Metal binding1051Iron 2 By similarity
Metal binding1081Iron 1 By similarity
Metal binding1681Iron 2 By similarity
Metal binding2021Iron 2 By similarity
Metal binding2051Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9DHU2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 4F34D6C6FFC62627

FASTA32537,836
        10         20         30         40         50         60 
MNTSCEPILK PTLNKYVVFP IVYEDIWKMY KKAVASFWTV EEVDLSKDFS DWLKLSDNEK 

        70         80         90        100        110        120 
NFIKHILAFF AASDGIVNEN LAERFYSEVQ ISEARCFYGF QIAMENIHSE MYSLLIDTYI 

       130        140        150        160        170        180 
LDSKEKNYLF NAIENMNCVK QKANWAKKWI ESKNRTYGER LVAFAAVEGI FFSGSFAAIF 

       190        200        210        220        230        240 
WIKKRGLMPG LTFSNELISR DEGLHCDFAC IMFKHLLNPP LNSVVRDIII EAVNIEKNFL 

       250        260        270        280        290        300 
TEAIPVKLIG MNCDLMKQYI EFVADRLLLE LGCDKYYCSK NPFDFMENIS LEGKTNFFEK 

       310        320 
RVSEYQKMSV MSNKKDNVFS LDIDF 

« Hide

References

[1]"The genome sequence of Yaba-like disease virus, a yatapoxvirus."
Lee H.-J., Essani K., Smith G.L.
Virology 281:170-192(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ293568 Genomic DNA. Translation: CAC21258.1.
RefSeqNP_073405.1. NC_002642.1.

3D structure databases

ProteinModelPortalQ9DHU2.
SMRQ9DHU2. Positions 6-287.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID918732.

Phylogenomic databases

ProtClustDBCLSP2509773.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_YLDV
AccessionPrimary (citable) accession number: Q9DHU2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2001
Last modified: December 11, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways