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Q9DHU2

- RIR2_YLDV

UniProt

Q9DHU2 - RIR2_YLDV

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

20L

Organism
Yaba-like disease virus (YLDV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron 1PROSITE-ProRule annotation
Metal bindingi105 – 1051Iron 1PROSITE-ProRule annotation
Metal bindingi105 – 1051Iron 2By similarity
Metal bindingi108 – 1081Iron 1PROSITE-ProRule annotation
Active sitei112 – 1121PROSITE-ProRule annotation
Metal bindingi168 – 1681Iron 2By similarity
Metal bindingi202 – 2021Iron 2By similarity
Metal bindingi205 – 2051Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Ordered Locus Names:20L
OrganismiYaba-like disease virus (YLDV)
Taxonomic identifieri132475 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Simiiformes [TaxID: 314293]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Ribonucleoside-diphosphate reductase small chainPRO_0000190501Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Structurei

3D structure databases

ProteinModelPortaliQ9DHU2.
SMRiQ9DHU2. Positions 6-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DHU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTSCEPILK PTLNKYVVFP IVYEDIWKMY KKAVASFWTV EEVDLSKDFS
60 70 80 90 100
DWLKLSDNEK NFIKHILAFF AASDGIVNEN LAERFYSEVQ ISEARCFYGF
110 120 130 140 150
QIAMENIHSE MYSLLIDTYI LDSKEKNYLF NAIENMNCVK QKANWAKKWI
160 170 180 190 200
ESKNRTYGER LVAFAAVEGI FFSGSFAAIF WIKKRGLMPG LTFSNELISR
210 220 230 240 250
DEGLHCDFAC IMFKHLLNPP LNSVVRDIII EAVNIEKNFL TEAIPVKLIG
260 270 280 290 300
MNCDLMKQYI EFVADRLLLE LGCDKYYCSK NPFDFMENIS LEGKTNFFEK
310 320
RVSEYQKMSV MSNKKDNVFS LDIDF
Length:325
Mass (Da):37,836
Last modified:March 1, 2001 - v1
Checksum:i4F34D6C6FFC62627
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293568 Genomic DNA. Translation: CAC21258.1.
RefSeqiNP_073405.1. NC_002642.1.

Genome annotation databases

GeneIDi918732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293568 Genomic DNA. Translation: CAC21258.1 .
RefSeqi NP_073405.1. NC_002642.1.

3D structure databases

ProteinModelPortali Q9DHU2.
SMRi Q9DHU2. Positions 6-287.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 918732.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Yaba-like disease virus, a yatapoxvirus."
    Lee H.-J., Essani K., Smith G.L.
    Virology 281:170-192(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_YLDV
AccessioniPrimary (citable) accession number: Q9DHU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3