Q9DHU2 (RIR2_YLDV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonucleoside-diphosphate reductase small chain
EC=1.17.4.1

Alternative name(s):
Ribonucleotide reductase small subunit

Gene names

Ordered Locus Names:

20L

Organism

Yaba-like disease virus (YLDV)

Taxonomic identifier

132475 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Yatapoxvirus › Tanapox virus

Virus host

Homo sapiens (Human) [TaxID: 9606]
Simiiformes [TaxID: 314293]

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.
Catalytic activity	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Genetic information processing; DNA replication.
Subunit structure	Heterodimer of a large and a small chain.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Keywords
Biological process	DNA replication
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-UniPathway deoxyribonucleoside diphosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Ribonucleoside-diphosphate reductase small chain		PRO_0000190501
Sites
	Active site	112	1	By similarity
	Metal binding	74	1	Iron 1 By similarity
	Metal binding	105	1	Iron 1 By similarity
	Metal binding	105	1	Iron 2 By similarity
	Metal binding	108	1	Iron 1 By similarity
	Metal binding	168	1	Iron 2 By similarity
	Metal binding	202	1	Iron 2 By similarity
	Metal binding	205	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9DHU2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4F34D6C6FFC62627	FASTA	325	37,836
	10 20 30 40 50 60 MNTSCEPILK PTLNKYVVFP IVYEDIWKMY KKAVASFWTV EEVDLSKDFS DWLKLSDNEK 70 80 90 100 110 120 NFIKHILAFF AASDGIVNEN LAERFYSEVQ ISEARCFYGF QIAMENIHSE MYSLLIDTYI 130 140 150 160 170 180 LDSKEKNYLF NAIENMNCVK QKANWAKKWI ESKNRTYGER LVAFAAVEGI FFSGSFAAIF 190 200 210 220 230 240 WIKKRGLMPG LTFSNELISR DEGLHCDFAC IMFKHLLNPP LNSVVRDIII EAVNIEKNFL 250 260 270 280 290 300 TEAIPVKLIG MNCDLMKQYI EFVADRLLLE LGCDKYYCSK NPFDFMENIS LEGKTNFFEK 310 320 RVSEYQKMSV MSNKKDNVFS LDIDF

References

[1]	"The genome sequence of Yaba-like disease virus, a yatapoxvirus." Lee H.-J., Essani K., Smith G.L. Virology 281:170-192(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ293568 Genomic DNA. Translation: CAC21258.1.
RefSeq	NP_073405.1. NC_002642.1.
3D structure databases
ProteinModelPortal	Q9DHU2.
SMR	Q9DHU2. Positions 6-287.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	918732.
Phylogenomic databases
ProtClustDB	CLSP2509773.
Enzyme and pathway databases
UniPathway	UPA00326.
Family and domain databases
Gene3D	1.10.620.20. 1 hit.
InterPro	IPR009078. Ferritin-like_SF. IPR012348. RNR-rel. IPR000358. RNR_small. [Graphical view]
PANTHER	PTHR23409. PTHR23409. 1 hit.
Pfam	PF00268. Ribonuc_red_sm. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00368. RIBORED_SMALL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIR2_YLDV

Accession

Primary (citable) accession number: Q9DHU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program