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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

20L

Organism
Yaba-like disease virus (YLDV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Iron 1PROSITE-ProRule annotation1
Metal bindingi105Iron 1PROSITE-ProRule annotation1
Metal bindingi105Iron 2By similarity1
Metal bindingi108Iron 1PROSITE-ProRule annotation1
Active sitei112PROSITE-ProRule annotation1
Metal bindingi168Iron 2By similarity1
Metal bindingi202Iron 2By similarity1
Metal bindingi205Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Ordered Locus Names:20L
OrganismiYaba-like disease virus (YLDV)
Taxonomic identifieri132475 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Simiiformes [TaxID: 314293]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001905011 – 325Ribonucleoside-diphosphate reductase small chainAdd BLAST325

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Structurei

3D structure databases

ProteinModelPortaliQ9DHU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10808.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DHU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSCEPILK PTLNKYVVFP IVYEDIWKMY KKAVASFWTV EEVDLSKDFS
60 70 80 90 100
DWLKLSDNEK NFIKHILAFF AASDGIVNEN LAERFYSEVQ ISEARCFYGF
110 120 130 140 150
QIAMENIHSE MYSLLIDTYI LDSKEKNYLF NAIENMNCVK QKANWAKKWI
160 170 180 190 200
ESKNRTYGER LVAFAAVEGI FFSGSFAAIF WIKKRGLMPG LTFSNELISR
210 220 230 240 250
DEGLHCDFAC IMFKHLLNPP LNSVVRDIII EAVNIEKNFL TEAIPVKLIG
260 270 280 290 300
MNCDLMKQYI EFVADRLLLE LGCDKYYCSK NPFDFMENIS LEGKTNFFEK
310 320
RVSEYQKMSV MSNKKDNVFS LDIDF
Length:325
Mass (Da):37,836
Last modified:March 1, 2001 - v1
Checksum:i4F34D6C6FFC62627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293568 Genomic DNA. Translation: CAC21258.1.
RefSeqiNP_073405.1. NC_002642.1.

Genome annotation databases

GeneIDi918732.
KEGGivg:918732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293568 Genomic DNA. Translation: CAC21258.1.
RefSeqiNP_073405.1. NC_002642.1.

3D structure databases

ProteinModelPortaliQ9DHU2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi918732.
KEGGivg:918732.

Phylogenomic databases

KOiK10808.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_YLDV
AccessioniPrimary (citable) accession number: Q9DHU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.