ID   PAP1_YLDV               Reviewed;         470 AA.
AC   Q9DHT0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   08-NOV-2023, entry version 72.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
GN   Name=PAPL; OrderedLocusNames=32L;
OS   Yaba-like disease virus (YLDV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus; Tanapox virus.
OX   NCBI_TaxID=132475;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=314293; Simiiformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11277691; DOI=10.1006/viro.2000.0761;
RA   Lee H.-J., Essani K., Smith G.L.;
RT   "The genome sequence of Yaba-like disease virus, a yatapoxvirus.";
RL   Virology 281:170-192(2001).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AJ293568; CAC21270.1; -; Genomic_DNA.
DR   RefSeq; NP_073417.1; NC_002642.1.
DR   SMR; Q9DHT0; -.
DR   GeneID; 918743; -.
DR   KEGG; vg:918743; -.
DR   OrthoDB; 3428at10239; -.
DR   Proteomes; UP000136581; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd20919; polyA_pol_Pox; 1.
DR   Gene3D; 1.20.1270.320; Poxvirus poly(A) polymerase, N domain; 1.
DR   Gene3D; 3.30.460.60; Poxvirus poly(A) polymerase, nucleotidyltransferase domain; 1.
DR   InterPro; IPR004976; PolyA_pol_cat_Poxvir.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; PolyA_pol_nucTrfase_Poxvir.
DR   InterPro; IPR038419; PolyA_pol_nucTrfase_sf_Poxvir.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; Poly(A) polymerase catalytic subunit-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Transcription;
KW   Transferase.
FT   CHAIN           1..470
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000308943"
FT   ACT_SITE        192
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   470 AA;  54272 MW;  4B589FB8D6760FE4 CRC64;
     MSNSITLTLK NYLGRMPTIN EYHMLKSQVR NIQKIMFFNK DIFISLIKKN KKKFFSEIKS
     SPSEIKTHIL EYFLKQQKTS SIGKLYTIIE LQTILVSSYT DVLGVLTTKS PYVFPSNIKY
     EPHSMKKIAH DILTSINVAT ISEKVMGRHN VSNLVTNVNL LMEEYLRRHN KSCICYGSYS
     LYLLNPSIKY GDIDILQTNS RIFLINLAFL IKFITGHNVM LLKVPYLKNY MVLRDNEDKH
     IIDSFNVRQE TMHAIPKILI DNIYIVDPTF QLLSMIKMFS QIDRLEDLAK NQEKATIKLA
     TLLEYVRIKH GIILNGNVTN MPMPASFNYE KRIVTVDASK YNFSFKKCFV YLDENSLSSD
     ILDLNADDAI DFENVSNSVF LINDEVMYTY FSNTILMSSK NEIHEISARG VSAHILMYQI
     LTDGDFLIPL SDIINSLMFK EKTPIFNIIP RDKKTGKHGI INIEKDIITH
//