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Q9DHT0

- PAP1_YLDV

UniProt

Q9DHT0 - PAP1_YLDV

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Protein
Poly(A) polymerase catalytic subunit
Gene
PAPL, 32L
Organism
Yaba-like disease virus (YLDV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921 By similarity
Active sitei194 – 1941 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:32L
OrganismiYaba-like disease virus (YLDV)
Taxonomic identifieri132475 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Simiiformes [TaxID: 314293]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Poly(A) polymerase catalytic subunit
PRO_0000308943Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9DHT0.
SMRiQ9DHT0. Positions 9-468.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DHT0-1 [UniParc]FASTAAdd to Basket

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MSNSITLTLK NYLGRMPTIN EYHMLKSQVR NIQKIMFFNK DIFISLIKKN    50
KKKFFSEIKS SPSEIKTHIL EYFLKQQKTS SIGKLYTIIE LQTILVSSYT 100
DVLGVLTTKS PYVFPSNIKY EPHSMKKIAH DILTSINVAT ISEKVMGRHN 150
VSNLVTNVNL LMEEYLRRHN KSCICYGSYS LYLLNPSIKY GDIDILQTNS 200
RIFLINLAFL IKFITGHNVM LLKVPYLKNY MVLRDNEDKH IIDSFNVRQE 250
TMHAIPKILI DNIYIVDPTF QLLSMIKMFS QIDRLEDLAK NQEKATIKLA 300
TLLEYVRIKH GIILNGNVTN MPMPASFNYE KRIVTVDASK YNFSFKKCFV 350
YLDENSLSSD ILDLNADDAI DFENVSNSVF LINDEVMYTY FSNTILMSSK 400
NEIHEISARG VSAHILMYQI LTDGDFLIPL SDIINSLMFK EKTPIFNIIP 450
RDKKTGKHGI INIEKDIITH 470
Length:470
Mass (Da):54,272
Last modified:March 1, 2001 - v1
Checksum:i4B589FB8D6760FE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293568 Genomic DNA. Translation: CAC21270.1.
RefSeqiNP_073417.1. NC_002642.1.

Genome annotation databases

GeneIDi918743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293568 Genomic DNA. Translation: CAC21270.1 .
RefSeqi NP_073417.1. NC_002642.1.

3D structure databases

ProteinModelPortali Q9DHT0.
SMRi Q9DHT0. Positions 9-468.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 918743.

Family and domain databases

InterProi IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view ]
Pfami PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Yaba-like disease virus, a yatapoxvirus."
    Lee H.-J., Essani K., Smith G.L.
    Virology 281:170-192(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_YLDV
AccessioniPrimary (citable) accession number: Q9DHT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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