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Q9DHT0

- PAP1_YLDV

UniProt

Q9DHT0 - PAP1_YLDV

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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Yaba-like disease virus (YLDV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921By similarity
Active sitei194 – 1941By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:32L
OrganismiYaba-like disease virus (YLDV)
Taxonomic identifieri132475 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Simiiformes [TaxID: 314293]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308943Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9DHT0.
SMRiQ9DHT0. Positions 9-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DHT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNSITLTLK NYLGRMPTIN EYHMLKSQVR NIQKIMFFNK DIFISLIKKN
60 70 80 90 100
KKKFFSEIKS SPSEIKTHIL EYFLKQQKTS SIGKLYTIIE LQTILVSSYT
110 120 130 140 150
DVLGVLTTKS PYVFPSNIKY EPHSMKKIAH DILTSINVAT ISEKVMGRHN
160 170 180 190 200
VSNLVTNVNL LMEEYLRRHN KSCICYGSYS LYLLNPSIKY GDIDILQTNS
210 220 230 240 250
RIFLINLAFL IKFITGHNVM LLKVPYLKNY MVLRDNEDKH IIDSFNVRQE
260 270 280 290 300
TMHAIPKILI DNIYIVDPTF QLLSMIKMFS QIDRLEDLAK NQEKATIKLA
310 320 330 340 350
TLLEYVRIKH GIILNGNVTN MPMPASFNYE KRIVTVDASK YNFSFKKCFV
360 370 380 390 400
YLDENSLSSD ILDLNADDAI DFENVSNSVF LINDEVMYTY FSNTILMSSK
410 420 430 440 450
NEIHEISARG VSAHILMYQI LTDGDFLIPL SDIINSLMFK EKTPIFNIIP
460 470
RDKKTGKHGI INIEKDIITH
Length:470
Mass (Da):54,272
Last modified:March 1, 2001 - v1
Checksum:i4B589FB8D6760FE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293568 Genomic DNA. Translation: CAC21270.1.
RefSeqiNP_073417.1. NC_002642.1.

Genome annotation databases

GeneIDi918743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293568 Genomic DNA. Translation: CAC21270.1 .
RefSeqi NP_073417.1. NC_002642.1.

3D structure databases

ProteinModelPortali Q9DHT0.
SMRi Q9DHT0. Positions 9-468.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 918743.

Family and domain databases

InterProi IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view ]
Pfami PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Yaba-like disease virus, a yatapoxvirus."
    Lee H.-J., Essani K., Smith G.L.
    Virology 281:170-192(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_YLDV
AccessioniPrimary (citable) accession number: Q9DHT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3