Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitogen-activated protein kinase

Gene

mapk3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • brain development Source: ZFIN
  • central nervous system projection neuron axonogenesis Source: ZFIN
  • chordate embryonic development Source: ZFIN
  • eye development Source: ZFIN

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:mapk3Imported
Synonyms:zERK1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040121-1. mapk3.

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiQ9DGR6.
PRIDEiQ9DGR6.

Structurei

3D structure databases

ProteinModelPortaliQ9DGR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 343Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOVERGENiHBG014652.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DGR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESGSSAAA AEPGSNSSAA GPGGAVAPGG PSGAAGSKPG LESVKGQNFD
60 70 80 90 100
VGPRYTDLQY IGEGAYGMVC SAFDNVNKIR VAIKKISPFE HQTYCQRTLR
110 120 130 140 150
EIKILLRFHH ENIIGINDIL RARHIDYMRD VYIVQDLMET DLYKLLKTQQ
160 170 180 190 200
LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLINTT CDLKICDFGL
210 220 230 240 250
ARIADPEHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE
260 270 280 290 300
MLSNRPIFPG KHYLDQLNHI LGVLGSPSQD DLNCIINMKA RNYLQSLPQK
310 320 330 340 350
PKIPWNKLFP KADNKALDLL DRMLTFNPIK RINVEQALAH PYLEQYYDPS
360 370 380 390
DEPVAEEPFT FNMELDDLPK EKLKELIFEE TARFQANYQG S
Length:391
Mass (Da):44,126
Last modified:March 1, 2001 - v1
Checksum:i6638F0807B5F9889
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030902 mRNA. Translation: BAB11812.1.
UniGeneiDr.75913.

Similar proteinsi

Entry informationi

Entry nameiQ9DGR6_DANRE
AccessioniPrimary (citable) accession number: Q9DGR6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)