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Protein

Mitogen-activated protein kinase

Gene

mapk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • gastrulation Source: ZFIN

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:mapk1Imported
Synonyms:zERK2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030722-2. mapk1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ9DGR5.

Structurei

3D structure databases

ProteinModelPortaliQ9DGR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 322Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOVERGENiHBG014652.
PhylomeDBiQ9DGR5.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DGR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAAVSAPA GGGPNPGSGA EMVRGQAFDV GPRYSNLSYI GEGAYGMVCS
60 70 80 90 100
AYDRDNKVRV AIKKISPFEH QTYCQRTLRE IKIPVRFKHE NIIGINDIIR
110 120 130 140 150
TPTIDQMKDV YIVQDLMETD LYKLLKTQHL SNDHICYFLY QILRGLKYIH
160 170 180 190 200
SANVLHRDLK PSNLLLNTTC DLKICDFGLA RVADPDHDHT GFLTEYVATR
210 220 230 240 250
WYRAPEIMLN SKGYTKSIDI WSVGCILAEM LSNRPIFPGK HYLDQLNHIL
260 270 280 290 300
GILGSPSQED LNCIINIKAR NYLLSLPLRS KVPWNRLFPN ADPKALDLLD
310 320 330 340 350
KMLTFNPHKR IEVEEALAHP YLEQYYDPTD EPVAEAPFKF DMELDDLPKE
360
TLKELIFEET ARFQPGNRP
Length:369
Mass (Da):42,068
Last modified:March 1, 2001 - v1
Checksum:iDBC6AFECC4DD51AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030903 mRNA. Translation: BAB11813.1.
UniGeneiDr.10452.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9DGR5_DANRE
AccessioniPrimary (citable) accession number: Q9DGR5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)