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Protein

Translationally-controlled tumor protein homolog

Gene

tpt1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Gene namesi
Name:tpt1
Synonyms:tct1, tctp
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-990603-10. tpt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Translationally-controlled tumor protein homologPRO_0000211274Add
BLAST

Proteomic databases

PaxDbiQ9DGK4.
PRIDEiQ9DGK4.

Expressioni

Gene expression databases

BgeeiQ9DGK4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110449.

Structurei

3D structure databases

ProteinModelPortaliQ9DGK4.
SMRiQ9DGK4. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 171171TCTPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiQ9DGK4.
OrthoDBiEOG7SJD61.
PhylomeDBiQ9DGK4.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DGK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYKDIITG DEMFSDIYKI KESENGMMLE VEGKMITRAE GDIDDALIGG
60 70 80 90 100
NASAEVADEG CDSTSVSGVD IVLNHKLQET SYDKKSYTAY IKDYMKAVKA
110 120 130 140 150
KLQESAPNRV DPFMANAPAE VKKILGNIKN FQFFTGESMN PDGMIGLLDF
160 170
REDGVTPYMI FFKDGLEIEK C
Length:171
Mass (Da):19,025
Last modified:March 1, 2001 - v1
Checksum:i2D56CDCDAA74DE5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611F → S in AAH49059 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288217 mRNA. Translation: AAF99708.1.
BC049059 mRNA. Translation: AAH49059.1.
RefSeqiNP_937783.1. NM_198140.1.
UniGeneiDr.75674.

Genome annotation databases

EnsembliENSDART00000102111; ENSDARP00000092887; ENSDARG00000092693.
GeneIDi30723.
KEGGidre:30723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288217 mRNA. Translation: AAF99708.1.
BC049059 mRNA. Translation: AAH49059.1.
RefSeqiNP_937783.1. NM_198140.1.
UniGeneiDr.75674.

3D structure databases

ProteinModelPortaliQ9DGK4.
SMRiQ9DGK4. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110449.

Proteomic databases

PaxDbiQ9DGK4.
PRIDEiQ9DGK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000102111; ENSDARP00000092887; ENSDARG00000092693.
GeneIDi30723.
KEGGidre:30723.

Organism-specific databases

CTDi7178.
ZFINiZDB-GENE-990603-10. tpt1.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiQ9DGK4.
OrthoDBiEOG7SJD61.
PhylomeDBiQ9DGK4.
TreeFamiTF300238.

Miscellaneous databases

PROiQ9DGK4.

Gene expression databases

BgeeiQ9DGK4.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish gene encoding the translationally-controlled tumor protein 1 (tct1) is ubiquitously expressed during early development."
    Good P.J.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTCTP_DANRE
AccessioniPrimary (citable) accession number: Q9DGK4
Secondary accession number(s): Q7ZUG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.