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Q9DGH0 (TWS1A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Twisted gastrulation protein homolog 1-A
Gene names
Name:twsg1a
Synonyms:tsg, twsg1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd-independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the twisted gastrulation protein family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood vessel development

Inferred from genetic interaction PubMed 15525664. Source: ZFIN

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 217191Twisted gastrulation protein homolog 1-A
PRO_0000278812

Regions

Compositional bias27 – 7852Cys-rich

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9DGH0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 94C351F2CD829EDE

FASTA21723,925
        10         20         30         40         50         60 
MRPALFLCPV LISVLFLLSS LSLISGCNKA LCASDVSKCL LQGLCQCRPQ EGNCSCCKEC 

        70         80         90        100        110        120 
MLCLSSLWEE CCDCVGMCNP RSYNDSPATS KSTVEELYRP IPSLFRALTE GDAPINMMVV 

       130        140        150        160        170        180 
SFPVAEELSH HENLVSFLET LDSQSQNISL PTSSAQDDAL CTVVYFDDCV SIRQCKQYCE 

       190        200        210 
SMGGSKYRWF HNACCECIGP ECLDYGSKTV KCMNCLI 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation."
Graf D., Timmons P.M., Hitchins M., Episkopou V., Moore G., Ito T., Fujiyama A., Fisher A.G., Merkenschlager M.
Mamm. Genome 12:554-560(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Erratum
Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
Nature 411:720-720(2001)
[4]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ297393 mRNA. Translation: CAC05526.1.
AF261692 mRNA. Translation: AAK13255.1.
BC051451 mRNA. Translation: AAH51451.1.
RefSeqNP_571872.1. NM_131797.2.
UniGeneDr.45891.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID84037.
KEGGdre:84037.

Organism-specific databases

CTD84037.
ZFINZDB-GENE-010509-2. twsg1a.

Phylogenomic databases

eggNOGNOG70213.
HOGENOMHOG000044674.
HOVERGENHBG055753.
InParanoidQ9DGH0.
PhylomeDBQ9DGH0.

Family and domain databases

InterProIPR006761. Tsg.
[Graphical view]
PANTHERPTHR12312. PTHR12312. 1 hit.
PfamPF04668. Tsg. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20934200.
PROQ9DGH0.

Entry information

Entry nameTWS1A_DANRE
AccessionPrimary (citable) accession number: Q9DGH0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families