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Protein

Twisted gastrulation protein homolog 1-A

Gene

twsg1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd-independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization (By similarity).By similarity

GO - Biological processi

  1. blood vessel development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Twisted gastrulation protein homolog 1-A
Gene namesi
Name:twsg1a
Synonyms:tsg, twsg1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-010509-2. twsg1a.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 217191Twisted gastrulation protein homolog 1-APRO_0000278812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 7852Cys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG70213.
HOGENOMiHOG000044674.
HOVERGENiHBG055753.
InParanoidiQ9DGH0.
PhylomeDBiQ9DGH0.

Family and domain databases

InterProiIPR006761. Tsg.
[Graphical view]
PANTHERiPTHR12312. PTHR12312. 1 hit.
PfamiPF04668. Tsg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DGH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPALFLCPV LISVLFLLSS LSLISGCNKA LCASDVSKCL LQGLCQCRPQ
60 70 80 90 100
EGNCSCCKEC MLCLSSLWEE CCDCVGMCNP RSYNDSPATS KSTVEELYRP
110 120 130 140 150
IPSLFRALTE GDAPINMMVV SFPVAEELSH HENLVSFLET LDSQSQNISL
160 170 180 190 200
PTSSAQDDAL CTVVYFDDCV SIRQCKQYCE SMGGSKYRWF HNACCECIGP
210
ECLDYGSKTV KCMNCLI
Length:217
Mass (Da):23,925
Last modified:March 1, 2001 - v1
Checksum:i94C351F2CD829EDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297393 mRNA. Translation: CAC05526.1.
AF261692 mRNA. Translation: AAK13255.1.
BC051451 mRNA. Translation: AAH51451.1.
RefSeqiNP_571872.1. NM_131797.2.
UniGeneiDr.45891.

Genome annotation databases

GeneIDi84037.
KEGGidre:84037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297393 mRNA. Translation: CAC05526.1.
AF261692 mRNA. Translation: AAK13255.1.
BC051451 mRNA. Translation: AAH51451.1.
RefSeqiNP_571872.1. NM_131797.2.
UniGeneiDr.45891.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84037.
KEGGidre:84037.

Organism-specific databases

CTDi84037.
ZFINiZDB-GENE-010509-2. twsg1a.

Phylogenomic databases

eggNOGiNOG70213.
HOGENOMiHOG000044674.
HOVERGENiHBG055753.
InParanoidiQ9DGH0.
PhylomeDBiQ9DGH0.

Miscellaneous databases

NextBioi20934200.
PROiQ9DGH0.

Family and domain databases

InterProiIPR006761. Tsg.
[Graphical view]
PANTHERiPTHR12312. PTHR12312. 1 hit.
PfamiPF04668. Tsg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation."
    Graf D., Timmons P.M., Hitchins M., Episkopou V., Moore G., Ito T., Fujiyama A., Fisher A.G., Merkenschlager M.
    Mamm. Genome 12:554-560(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
    Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
    Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiTWS1A_DANRE
AccessioniPrimary (citable) accession number: Q9DGH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.