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Q9DGH0

- TWS1A_DANRE

UniProt

Q9DGH0 - TWS1A_DANRE

Protein

Twisted gastrulation protein homolog 1-A

Gene

twsg1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd-independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization By similarity.By similarity

    GO - Biological processi

    1. blood vessel development Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Twisted gastrulation protein homolog 1-A
    Gene namesi
    Name:twsg1a
    Synonyms:tsg, twsg1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-010509-2. twsg1a.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 217191Twisted gastrulation protein homolog 1-APRO_0000278812Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 7852Cys-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG70213.
    HOGENOMiHOG000044674.
    HOVERGENiHBG055753.
    InParanoidiQ9DGH0.
    PhylomeDBiQ9DGH0.

    Family and domain databases

    InterProiIPR006761. Tsg.
    [Graphical view]
    PANTHERiPTHR12312. PTHR12312. 1 hit.
    PfamiPF04668. Tsg. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DGH0-1 [UniParc]FASTAAdd to Basket

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    MRPALFLCPV LISVLFLLSS LSLISGCNKA LCASDVSKCL LQGLCQCRPQ    50
    EGNCSCCKEC MLCLSSLWEE CCDCVGMCNP RSYNDSPATS KSTVEELYRP 100
    IPSLFRALTE GDAPINMMVV SFPVAEELSH HENLVSFLET LDSQSQNISL 150
    PTSSAQDDAL CTVVYFDDCV SIRQCKQYCE SMGGSKYRWF HNACCECIGP 200
    ECLDYGSKTV KCMNCLI 217
    Length:217
    Mass (Da):23,925
    Last modified:March 1, 2001 - v1
    Checksum:i94C351F2CD829EDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297393 mRNA. Translation: CAC05526.1.
    AF261692 mRNA. Translation: AAK13255.1.
    BC051451 mRNA. Translation: AAH51451.1.
    RefSeqiNP_571872.1. NM_131797.2.
    UniGeneiDr.45891.

    Genome annotation databases

    GeneIDi84037.
    KEGGidre:84037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297393 mRNA. Translation: CAC05526.1 .
    AF261692 mRNA. Translation: AAK13255.1 .
    BC051451 mRNA. Translation: AAH51451.1 .
    RefSeqi NP_571872.1. NM_131797.2.
    UniGenei Dr.45891.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84037.
    KEGGi dre:84037.

    Organism-specific databases

    CTDi 84037.
    ZFINi ZDB-GENE-010509-2. twsg1a.

    Phylogenomic databases

    eggNOGi NOG70213.
    HOGENOMi HOG000044674.
    HOVERGENi HBG055753.
    InParanoidi Q9DGH0.
    PhylomeDBi Q9DGH0.

    Miscellaneous databases

    NextBioi 20934200.
    PROi Q9DGH0.

    Family and domain databases

    InterProi IPR006761. Tsg.
    [Graphical view ]
    PANTHERi PTHR12312. PTHR12312. 1 hit.
    Pfami PF04668. Tsg. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation."
      Graf D., Timmons P.M., Hitchins M., Episkopou V., Moore G., Ito T., Fujiyama A., Fisher A.G., Merkenschlager M.
      Mamm. Genome 12:554-560(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
      Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
      Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.

    Entry informationi

    Entry nameiTWS1A_DANRE
    AccessioniPrimary (citable) accession number: Q9DGH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3