Q9DG45 (PHS2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pterin-4-alpha-carbinolamine dehydratase 2
Short name=PHS 2
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase 2
DCoH-alpha
DcoH-like protein DCoHm
Hepatocyte nuclear factor 1a dimerization cofactor isoform

Gene names

Name:	PCBD2
Synonyms:	DCOHM

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 By similarity. Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Tissue specificity	Highest level found in the kidney, liver, heart and ovarian follicles.
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Pterin-4-alpha-carbinolamine dehydratase 2		PRO_0000063059

Sequences

	Sequence		Length	Mass (Da)
	Q9DG45 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 2C76DEABA2EA36F7	FASTA	103	11,768
	10 20 30 40 50 60 MSSQSHWLTA EERTQVLLDL KASGWSESGE RDAIYKEFNF KNFNQAFGFM TRVALQAENM 70 80 90 100 NHHPEWFNVY SKVQITLISH DCGGLTKRDV KLAQFIDKAA ASV

References

[1]	"Differential expression of chicken dimerization cofactor of hepatocyte nuclear factor-1 (DcoH) and its novel counterpart, DcoHalpha." Kim H., You S., Foster L.K., Farris J., Choi Y.-J., Foster D.N. Biochem. J. 354:645-653(2001) [PubMed: 11237869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF190051 mRNA. Translation: AAG17122.1.
IPI	IPI00602324.
RefSeq	NP_989534.1. NM_204203.1.
UniGene	Gga.181.
3D structure databases
ProteinModelPortal	Q9DG45.
SMR	Q9DG45. Positions 5-103.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9DG45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	374030.
KEGG	gga:374030.
Organism-specific databases
CTD	84105.
Phylogenomic databases
eggNOG	veNOG20927.
GeneTree	ENSGT00390000007221.
HOGENOM	HBG705804.
HOVERGEN	HBG000259.
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
KO	K01724.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHS2_CHICK

Accession

Primary (citable) accession number: Q9DG45

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program