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Protein
Submitted name:

Hyaluronan synthase 2

Gene

has2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • atrioventricular canal development Source: ZFIN
  • atrioventricular valve development Source: ZFIN
  • atrioventricular valve morphogenesis Source: ZFIN
  • blood vessel development Source: ZFIN
  • cell adhesion Source: GO_Central
  • cell migration in hindbrain Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • dorsal convergence Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • extracellular matrix assembly Source: GO_Central
  • extracellular polysaccharide biosynthetic process Source: GO_Central
  • heart jogging Source: ZFIN
  • heart looping Source: ZFIN
  • hyaluronan biosynthetic process Source: UniProtKB
  • mesodermal cell migration Source: ZFIN
  • positive regulation of urine volume Source: UniProtKB
  • regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  • renal water absorption Source: UniProtKB
  • somitogenesis Source: ZFIN
Complete GO annotation...

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Submitted name:
Hyaluronan synthase 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:has2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-020828-1. has2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Transmembranei375 – 39723HelicalSequence analysisAdd
BLAST
Transmembranei403 – 41917HelicalSequence analysisAdd
BLAST
Transmembranei475 – 49723HelicalSequence analysisAdd
BLAST
Transmembranei509 – 53325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053753.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2571. Eukaryota.
COG1215. LUCA.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
KOiK00752.
OMAiTAYIMGY.
OrthoDBiEOG77WWBZ.
TreeFamiTF332506.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR026107. HAS/NodC.
IPR028371. HAS2.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF7. PTHR22913:SF7. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9DG41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCDKAVSYL RIVGTTLFGI SLLVGISTAY IMGYKLVTTP GNYLSFGLYG
60 70 80 90 100
AILVIHLIIQ SVFALLEHRN MKRSLETPIK LNKSLALCIA AYQEDPNYLR
110 120 130 140 150
KCLISVKRLT YPGIKVIMVI DGNNDDDCYM MEIFREIMGR DKAATYIWKS
160 170 180 190 200
NYHHRGPEET EESYATSLQH VSHLVLNNKC VCIMQKWGGK REVMYTAFKA
210 220 230 240 250
LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPNVGGVGG DVQILNKYES
260 270 280 290 300
WVSFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFLEDWY
310 320 330 340 350
DQTFMGSHCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PITYLRWLNQ
360 370 380 390 400
QTRWSKSYFR EWLYNSLWFH KHHLWMTYEA VITGFFPFFL IATAIQLFYQ
410 420 430 440 450
GRIWNILLFL LIVQVVALIK SSFASCLRGN IVMVFMSFYS VLYMSSLLPA
460 470 480 490 500
KMFAIATINK SGWGTSGRKT VVVNFIGLIP ISIWFTILFV GIIYTIIQET
510 520 530 540 550
RKPFPESEKV VLIIGAIVYI SYWVVFLTLY AVLIMKCGKR KKGQQYDMVL

DV
Length:552
Mass (Da):63,424
Last modified:March 1, 2001 - v1
Checksum:iB9B8F1BE332A788D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936449 Genomic DNA. No translation available.
AF190742 mRNA. Translation: AAG17180.1.
BC100130 mRNA. Translation: AAI00131.1.
RefSeqiNP_705936.1. NM_153650.2.
UniGeneiDr.82516.

Genome annotation databases

EnsembliENSDART00000053754; ENSDARP00000053753; ENSDARG00000036987.
GeneIDi260350.
KEGGidre:260350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936449 Genomic DNA. No translation available.
AF190742 mRNA. Translation: AAG17180.1.
BC100130 mRNA. Translation: AAI00131.1.
RefSeqiNP_705936.1. NM_153650.2.
UniGeneiDr.82516.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053753.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000053754; ENSDARP00000053753; ENSDARG00000036987.
GeneIDi260350.
KEGGidre:260350.

Organism-specific databases

CTDi3037.
ZFINiZDB-GENE-020828-1. has2.

Phylogenomic databases

eggNOGiKOG2571. Eukaryota.
COG1215. LUCA.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
KOiK00752.
OMAiTAYIMGY.
OrthoDBiEOG77WWBZ.
TreeFamiTF332506.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR026107. HAS/NodC.
IPR028371. HAS2.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF7. PTHR22913:SF7. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation."
    Bakkers J., Kramer C., Pothof J., Quaedvlieg N.E., Spaink H.P., Hammerschmidt M.
    Development 131:525-537(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9DG41_DANRE
AccessioniPrimary (citable) accession number: Q9DG41
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.