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Protein
Submitted name:

Hyaluronan synthase 2

Gene

has2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • atrioventricular canal development Source: ZFIN
  • atrioventricular valve development Source: ZFIN
  • atrioventricular valve morphogenesis Source: ZFIN
  • blood vessel development Source: ZFIN
  • cell adhesion Source: GO_Central
  • cell migration in hindbrain Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • dorsal convergence Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • extracellular matrix assembly Source: GO_Central
  • extracellular polysaccharide biosynthetic process Source: GO_Central
  • fin regeneration Source: ZFIN
  • heart jogging Source: ZFIN
  • heart looping Source: ZFIN
  • hyaluronan biosynthetic process Source: UniProtKB
  • mesodermal cell migration Source: ZFIN
  • positive regulation of urine volume Source: UniProtKB
  • regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  • renal water absorption Source: UniProtKB
  • somitogenesis Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-2142850 Hyaluronan biosynthesis and export

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Names & Taxonomyi

Protein namesi
Submitted name:
Hyaluronan synthase 2Imported
Gene namesi
Name:has2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-020828-1 has2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei375 – 397HelicalSequence analysisAdd BLAST23
Transmembranei403 – 419HelicalSequence analysisAdd BLAST17
Transmembranei475 – 497HelicalSequence analysisAdd BLAST23
Transmembranei509 – 533HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000036987

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053753

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2571 Eukaryota
COG1215 LUCA
GeneTreeiENSGT00390000010337
HOGENOMiHOG000112847
HOVERGENiHBG000189
KOiK00752
OMAiTAYIMGY
OrthoDBiEOG091G04P3
TreeFamiTF332506

Family and domain databases

InterProiView protein in InterPro
IPR028371 HAS2
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR22913:SF7 PTHR22913:SF7, 1 hit
SUPFAMiSSF53448 SSF53448, 2 hits

Sequencei

Sequence statusi: Complete.

Q9DG41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCDKAVSYL RIVGTTLFGI SLLVGISTAY IMGYKLVTTP GNYLSFGLYG
60 70 80 90 100
AILVIHLIIQ SVFALLEHRN MKRSLETPIK LNKSLALCIA AYQEDPNYLR
110 120 130 140 150
KCLISVKRLT YPGIKVIMVI DGNNDDDCYM MEIFREIMGR DKAATYIWKS
160 170 180 190 200
NYHHRGPEET EESYATSLQH VSHLVLNNKC VCIMQKWGGK REVMYTAFKA
210 220 230 240 250
LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPNVGGVGG DVQILNKYES
260 270 280 290 300
WVSFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFLEDWY
310 320 330 340 350
DQTFMGSHCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PITYLRWLNQ
360 370 380 390 400
QTRWSKSYFR EWLYNSLWFH KHHLWMTYEA VITGFFPFFL IATAIQLFYQ
410 420 430 440 450
GRIWNILLFL LIVQVVALIK SSFASCLRGN IVMVFMSFYS VLYMSSLLPA
460 470 480 490 500
KMFAIATINK SGWGTSGRKT VVVNFIGLIP ISIWFTILFV GIIYTIIQET
510 520 530 540 550
RKPFPESEKV VLIIGAIVYI SYWVVFLTLY AVLIMKCGKR KKGQQYDMVL

DV
Length:552
Mass (Da):63,424
Last modified:March 1, 2001 - v1
Checksum:iB9B8F1BE332A788D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936449 Genomic DNA No translation available.
AF190742 mRNA Translation: AAG17180.1
BC100130 mRNA Translation: AAI00131.1
RefSeqiNP_705936.1, NM_153650.2
UniGeneiDr.82516

Genome annotation databases

EnsembliENSDART00000053754; ENSDARP00000053753; ENSDARG00000036987
GeneIDi260350
KEGGidre:260350

Similar proteinsi

Entry informationi

Entry nameiQ9DG41_DANRE
AccessioniPrimary (citable) accession number: Q9DG41
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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