Reviewed, UniProtKB/Swiss-Prot Q9DG02 (KCC2D_XENLA)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II delta chain
      Short name=CaM-kinase II delta chain
      Short name=CaM kinase II subunit delta
      Short name=CaMK-II subunit delta
    EC=2.7.11.17

Gene names

Name:

camk2d

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Calcium/calmodulin-dependent protein kinase type II delta chain		PRO_0000277822
Regions
	Domain	13 – 271	259	Protein kinase
	Nucleotide binding	19 – 27	9	ATP By similarity
Sites
	Active site	135	1	Proton acceptor By similarity
	Binding site	42	1	ATP By similarity
Amino acid modifications
	Modified residue	286	1	Phosphothreonine By similarity
	Modified residue	314	1	Phosphoserine By similarity
	Modified residue	317	1	Phosphoserine By similarity
	Modified residue	335	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9DG02-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 7C312F4CB686A68A	FASTA	475	53,933
	10 20 30 40 50 60 MASTTCTRFT DEYQLFEELG KGAFSVVRRC IKINIGQEYA AKIINTKKLS ARDHQKLERE 70 80 90 100 110 120 AKICRLLKHP NIVRLHDSIS EEGFHYLVFD LVTGGELFED IVAREYYSEA DASHCIQQIL 130 140 150 160 170 180 ESVNHCHLNG IVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVQGDQQAW FGFAGTPGYL 190 200 210 220 230 240 SPEVLRKDPY GKPVDMWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 250 260 270 280 290 300 TPEAKDLINK MLTINPAKRI NATEALRHPW ICQRSTVASM MHRQETVDCL KKFNARRKLK 310 320 330 340 350 360 GAILTTMLAT RNFSAKSLLK KPDGVKESTE SSNTTIEDED VKARKQEIIK VTEQLIEAIN 370 380 390 400 410 420 NGDFEAYTKI CDPGLTSFEP EALGNLVEGM DFHRFYFENA LSKSNKPVHT IILNPHVHLI 430 440 450 460 470 GEDAACIAYI RLTQYLDSAG MPKTMQSEET RVWHRRDGKW QNVHFHRSGS PTIPN

References

[1]

"Cloning and differential expression of new calcium, calmodulin-dependent protein kinase II isoforms in Xenopus laevis oocytes and several adult tissues." Stevens I., Rondelez E., Merlevede W., Goris J. J. Biochem. 129:551-560(2001) [PubMed: 11275554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233629 mRNA. Translation: AAG17554.1.
RefSeq	NP_001083858.1.
UniGene	Xl.690
3D structure databases
HSSP	HSSP built from PDB template 2BDW based on UniProtKB Q9NG91.
SMR	Q9DG02. Positions 10-308, 334-472.
ModBase	Search...
Genome annotation databases
GeneID	399160.
KEGG	xla:399160.
Organism-specific databases
CTD	399160.
Xenbase	XB-FEAT-868292. camk2d.
Phylogenomic databases
HOVERGEN	Q9DG02.
Enzyme and pathway databases
BRENDA	2.7.11.17. 648.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_prot_kinase-like. IPR015742. Ca/CaM-dep_prot_kinase_2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
PANTHER	PTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit. PTHR22982:SF64. CaMKII. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCC2D_XENLA

Accession

Primary (citable) accession number: Q9DG02

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	March 1, 2001
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project