Q9DFY5 (Q9DFY5_RANCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: RC-RNase6 ribonuclease EMBL AAG31442.2
Organism	Rana catesbeiana (American bullfrog) (Lithobates catesbeiana) EMBL AAG31442.2
Taxonomic identifier	8400 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Raninae › Rana › Aquarana

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Signal EMBL AAG31442.2
Molecular function	Endonuclease SAAS SAAS023411 Hydrolase Nuclease
PTM	Disulfide bond SAAS SAAS023411
Technical term	3D-structure PDB 1OJ8 PDB 1OJ1
Gene Ontology (GO)
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential EMBL AAG31442.2
	Chain	24 – 128	105	RC-RNase6 ribonuclease EMBL AAG31442.2		PRO_5000058114

Sequences

	Sequence		Length	Mass (Da)
	Q9DFY5 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: AFEBFD67D266C7C2	FASTA	128	14,805
	10 20 30 40 50 60 MFPKFSFLLI FAVVLSLTHK SLCQDWDTFQ KKHLTDTKKV KCDVEMKKAL FDCKKTNTFI 70 80 90 100 110 120 FARPPRVQAL CKNIKDNTNV LSRDVFYLPQ CNRKKLPCHY RLDGSTNTIC LTCMKELPIH FAGVGKCP

References

[1]	"Purification and cloning of cytotoxic ribonucleases from Rana catesbeiana (bullfrog)." Liao Y.D., Huang H.C., Leu Y.J., Wei C.W., Tang P.C., Wang S.C. Nucleic Acids Res. 28:4097-4104(2000) [PubMed: 11058105] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAG31442.2.
[2]	Liao Y.-D., Huang H.-C., Leu Y.-J., Wei C.-W., Tang P.-C., Wang S.-C. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAG31442.2.
[3]	"Retro and Novel Binding Modes in Cytotoxic Ribonucleases from Rana Catesbeiana of Two Crystal Structures Complexed with (2',5'Cpg) and D(Apcpgpa)." Tsai C.-J., Liu J.-H., Liao Y.-D., Chen L.-Y., Cheng P.-T., Sun Y.-J. Submitted (JUL-2003) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 25-128.
[4]	"Nonproductive and Novel Binding Modes in Cytotoxic Ribonucleases from Rana Catesbeiana of Two Crystal Structures Complexed with C(2,5 Cpg) and D(Apcpgpa)." Tsai C.-J., Liu J.-H., Liao Y.-D., Chen L.-Y., Cheng P.-T., Sun Y.-J. Submitted (JUN-2003) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 25-128.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF242556 Genomic DNA. Translation: AAG31442.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OJ1	X-ray	2.10	A	25-128	[»]
1OJ8	X-ray	1.70	A	25-128	[»]

ProteinModelPortal

Q9DFY5.

SMR

Q9DFY5. Positions 24-128.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG008396.

Family and domain databases

InterPro

IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]

Gene3D

G3DSA:3.10.130.10. RNaseA. 1 hit.

Pfam

PF00074. RnaseA. 1 hit.
[Graphical view]

ProDom

PD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF54076. RNaseA. 1 hit.

PROSITE

PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9DFY5_RANCA

Accession

Primary (citable) accession number: Q9DFY5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)