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Protein

Eukaryotic translation initiation factor 4E-1A

Gene

eif4e1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.1 Publication

GO - Molecular functioni

  • RNA 7-methylguanosine cap binding Source: UniProtKB
  • translation initiation factor activity Source: UniProtKB

GO - Biological processi

  • regulation of translation Source: UniProtKB
  • translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-1A
Short name:
eIF4E-1A
Alternative name(s):
mRNA cap-binding protein
Gene namesi
Name:eif4e1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040413-1. eif4ea.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • eukaryotic translation initiation factor 4F complex Source: UniProtKB
  • mRNA cap binding complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Eukaryotic translation initiation factor 4E-1APRO_0000193638Add
BLAST

Proteomic databases

PaxDbiQ9DFS6.
PRIDEiQ9DFS6.

Expressioni

Tissue specificityi

Expressed in all tissues examined, including gill, fin, heart, intestine, muscle, ovary and testis.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Zygotic expression persists into the pharyngula stage.1 Publication

Interactioni

Subunit structurei

Interacts with eif4ebp3l.1 Publication

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103599.

Structurei

3D structure databases

ProteinModelPortaliQ9DFS6.
SMRiQ9DFS6. Positions 21-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 5527-methylguanosine-containing mRNA cap bindingBy similarity
Regioni100 – 10127-methylguanosine-containing mRNA cap bindingBy similarity
Regioni155 – 16067-methylguanosine-containing mRNA cap bindingBy similarity
Regioni203 – 20537-methylguanosine-containing mRNA cap bindingBy similarity

Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4E family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1670. Eukaryota.
COG5053. LUCA.
HOGENOMiHOG000186751.
HOVERGENiHBG006130.
InParanoidiQ9DFS6.
KOiK03259.
PhylomeDBiQ9DFS6.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DFS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAEPETST NPSNSEEKNE ENEQQIVSLE DYIKHPLQNR WALWFFKNDK
60 70 80 90 100
SKTWQANLRL ISKFDTVEDF WALYNHIQLS SNLMSGCDYS LFKDGIEPMW
110 120 130 140 150
EDERNKRGGR WLITLSKQQR RADLDRFWLE TLLCLVGEAF DDHSDDVCGA
160 170 180 190 200
VVNIRTKGDK IAIWTTDYEN KDAIVHIGRV YKERLGVPPK VIIGYQSHAD
210
TATKSGSTTK NKFVV
Length:215
Mass (Da):24,850
Last modified:March 1, 2001 - v1
Checksum:i606C1044C0E7FA58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257519 mRNA. Translation: AAG09794.1.
BC071364 mRNA. Translation: AAH71364.1.
RefSeqiNP_571808.1. NM_131733.1.
UniGeneiDr.5294.

Genome annotation databases

GeneIDi79380.
KEGGidre:79380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257519 mRNA. Translation: AAG09794.1.
BC071364 mRNA. Translation: AAH71364.1.
RefSeqiNP_571808.1. NM_131733.1.
UniGeneiDr.5294.

3D structure databases

ProteinModelPortaliQ9DFS6.
SMRiQ9DFS6. Positions 21-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103599.

Proteomic databases

PaxDbiQ9DFS6.
PRIDEiQ9DFS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79380.
KEGGidre:79380.

Organism-specific databases

CTDi79380.
ZFINiZDB-GENE-040413-1. eif4ea.

Phylogenomic databases

eggNOGiKOG1670. Eukaryota.
COG5053. LUCA.
HOGENOMiHOG000186751.
HOVERGENiHBG006130.
InParanoidiQ9DFS6.
KOiK03259.
PhylomeDBiQ9DFS6.

Miscellaneous databases

PROiQ9DFS6.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two zebrafish eIF4E family members are differentially expressed and functionally divergent."
    Robalino J., Joshi B., Fahrenkrug S.C., Jagus R.
    J. Biol. Chem. 279:10532-10541(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH EIF4EBP3L, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiIF4EA_DANRE
AccessioniPrimary (citable) accession number: Q9DFS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.