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Protein

StAR-related lipid transfer protein 3

Gene

stard3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and transports cholesterol. Promotes steroidogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Steroidogenesis, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 3
Alternative name(s):
MLN64-like protein
START domain-containing protein 3
Short name:
StARD3
Gene namesi
Name:stard3
Synonyms:mln64
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-001120-2. stard3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448StAR-related lipid transfer protein 3PRO_0000220655Add
BLAST

Proteomic databases

PaxDbiQ9DFS4.

Expressioni

Gene expression databases

BgeeiQ9DFS4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000007948.

Structurei

3D structure databases

ProteinModelPortaliQ9DFS4.
SMRiQ9DFS4. Positions 232-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 219173MENTALPROSITE-ProRule annotationAdd
BLAST
Domaini232 – 445214STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MENTAL domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ9DFS4.
OMAiCTFIWVL.
OrthoDBiEOG74FF0Z.
PhylomeDBiQ9DFS4.
TreeFamiTF313869.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019498. MENTAL.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DFS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAVDYSEL GGSLPAIASL NASYSQASLS LPSPYYCPLP PGERKAFSDV
60 70 80 90 100
RRTFCLFVTF DLLFITLLWI IELNISKSIW NSLENEVVHY NFKSSFFDIF
110 120 130 140 150
LLAVFRFLCL QLGYAAFRLR HWWVIAITTL VTTAFLIAKV ILSDLFSQNA
160 170 180 190 200
FGYVLPITSF VVAWLETWFL DFKVLTQEAE DERVYLAAVN AACEPAPLIC
210 220 230 240 250
PRPVSDGQFY SPPESLAGSE DDLDEEGLGR RAVTEQEKAF VRQGREAMAV
260 270 280 290 300
VEQILTQEEN WKFEKTNELG DAVYTLEIPF HGKTFILKGL LQCTAELVYQ
310 320 330 340 350
EVILQPEKMV QWNRTVSVCQ ILQRVDDNTM VSYDVSAGAA GGVVSPRDFV
360 370 380 390 400
NVRRVERRRD CYISAGMATN HNSKPHHSRY VRGENGPGGF VVLKSSSNPS
410 420 430 440
VCTFIWVLNT DLKGRLPRYL IHQSLAATMF EFMSHLRQRI NEVHVSYR
Length:448
Mass (Da):50,751
Last modified:February 1, 2005 - v2
Checksum:i716A18C127B59C5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 22011YSPPESLAGSE → PGRPRVRPRVR (PubMed:11064158).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056766 mRNA. Translation: AAH56766.1.
AF258786 mRNA. Translation: AAG28603.1.
RefSeqiNP_571737.1. NM_131662.1.
XP_005159410.1. XM_005159353.2.
UniGeneiDr.2274.

Genome annotation databases

EnsembliENSDART00000003634; ENSDARP00000007948; ENSDARG00000017809.
GeneIDi63998.
KEGGidre:63998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056766 mRNA. Translation: AAH56766.1.
AF258786 mRNA. Translation: AAG28603.1.
RefSeqiNP_571737.1. NM_131662.1.
XP_005159410.1. XM_005159353.2.
UniGeneiDr.2274.

3D structure databases

ProteinModelPortaliQ9DFS4.
SMRiQ9DFS4. Positions 232-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000007948.

Proteomic databases

PaxDbiQ9DFS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000003634; ENSDARP00000007948; ENSDARG00000017809.
GeneIDi63998.
KEGGidre:63998.

Organism-specific databases

CTDi10948.
ZFINiZDB-GENE-001120-2. stard3.

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ9DFS4.
OMAiCTFIWVL.
OrthoDBiEOG74FF0Z.
PhylomeDBiQ9DFS4.
TreeFamiTF313869.

Miscellaneous databases

PROiQ9DFS4.

Gene expression databases

BgeeiQ9DFS4.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019498. MENTAL.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
  2. "Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates."
    Bauer M.P., Bridgham J.T., Langenau D.M., Johnson A.L., Goetz F.W.
    Mol. Cell. Endocrinol. 168:119-125(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 210-448.

Entry informationi

Entry nameiSTAR3_DANRE
AccessioniPrimary (citable) accession number: Q9DFS4
Secondary accession number(s): Q6PH03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: February 1, 2005
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.