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Protein

StAR-related lipid transfer protein 3

Gene

stard3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-DRE-196108. Pregnenolone biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 3Curated
Alternative name(s):
MLN64-like proteinBy similarity
START domain-containing protein 3By similarity
Short name:
StARD3By similarity
Gene namesi
Name:stard3By similarity
Synonyms:mln64By similarity
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-001120-2. stard3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206551 – 448StAR-related lipid transfer protein 3Add BLAST448

Proteomic databases

PaxDbiQ9DFS4.

Expressioni

Gene expression databases

BgeeiENSDARG00000017809.
ExpressionAtlasiQ9DFS4. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000007948.

Structurei

3D structure databases

ProteinModelPortaliQ9DFS4.
SMRiQ9DFS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 219MENTALPROSITE-ProRule annotationAdd BLAST173
Domaini232 – 445STARTPROSITE-ProRule annotationAdd BLAST214

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi209 – 214FFATBy similarity6

Domaini

The START domain mediates lipid-transfer between membranes. It contains a hydrophobic cavity able to accommodate one lipid molecule, thereby serving as a 'hydrophobic bridge' across the aqueous gap between donor and acceptor organelle membranes.By similarity
The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol.By similarity

Sequence similaritiesi

Belongs to the STARD3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ9DFS4.
OMAiFHLRQRI.
OrthoDBiEOG091G06RM.
PhylomeDBiQ9DFS4.
TreeFamiTF313869.

Family and domain databases

CDDicd08906. START_STARD3-like. 1 hit.
Gene3Di3.30.530.20. 1 hit.
InterProiView protein in InterPro
IPR019498. MENTAL.
IPR000799. StAR-like.
IPR029867. STARD3_MLN64_C.
IPR023393. START-like_dom_sf.
IPR002913. START_lipid-bd_dom.
PfamiView protein in Pfam
PF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
PRINTSiPR00978. STARPROTEIN.
SMARTiView protein in SMART
SM00234. START. 1 hit.
PROSITEiView protein in PROSITE
PS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DFS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAVDYSEL GGSLPAIASL NASYSQASLS LPSPYYCPLP PGERKAFSDV
60 70 80 90 100
RRTFCLFVTF DLLFITLLWI IELNISKSIW NSLENEVVHY NFKSSFFDIF
110 120 130 140 150
LLAVFRFLCL QLGYAAFRLR HWWVIAITTL VTTAFLIAKV ILSDLFSQNA
160 170 180 190 200
FGYVLPITSF VVAWLETWFL DFKVLTQEAE DERVYLAAVN AACEPAPLIC
210 220 230 240 250
PRPVSDGQFY SPPESLAGSE DDLDEEGLGR RAVTEQEKAF VRQGREAMAV
260 270 280 290 300
VEQILTQEEN WKFEKTNELG DAVYTLEIPF HGKTFILKGL LQCTAELVYQ
310 320 330 340 350
EVILQPEKMV QWNRTVSVCQ ILQRVDDNTM VSYDVSAGAA GGVVSPRDFV
360 370 380 390 400
NVRRVERRRD CYISAGMATN HNSKPHHSRY VRGENGPGGF VVLKSSSNPS
410 420 430 440
VCTFIWVLNT DLKGRLPRYL IHQSLAATMF EFMSHLRQRI NEVHVSYR
Length:448
Mass (Da):50,751
Last modified:February 1, 2005 - v2
Checksum:i716A18C127B59C5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210 – 220YSPPESLAGSE → PGRPRVRPRVR (PubMed:11064158).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056766 mRNA. Translation: AAH56766.1.
AF258786 mRNA. Translation: AAG28603.1.
RefSeqiNP_571737.1. NM_131662.1.
XP_005159410.1. XM_005159353.3.
UniGeneiDr.2274.

Genome annotation databases

EnsembliENSDART00000003634; ENSDARP00000007948; ENSDARG00000017809.
GeneIDi63998.
KEGGidre:63998.

Similar proteinsi

Entry informationi

Entry nameiSTAR3_DANRE
AccessioniPrimary (citable) accession number: Q9DFS4
Secondary accession number(s): Q6PH03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: February 1, 2005
Last modified: November 22, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families