##gff-version 3 A0A1D5PXA5 UniProtKB Chain 1 852 . . . ID=PRO_0000443481;Note=Transient receptor potential cation channel subfamily V member 4 A0A1D5PXA5 UniProtKB Topological domain 1 455 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Transmembrane 456 476 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 477 493 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Transmembrane 494 520 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 521 533 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Transmembrane 534 554 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 555 558 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Transmembrane 559 579 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 580 594 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Transmembrane 595 622 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 623 651 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Intramembrane 652 671 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 672 679 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Transmembrane 680 708 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Topological domain 709 852 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Repeat 223 252 . . . Note=ANK 1;Ontology_term=ECO:0000255;evidence=ECO:0000255 A0A1D5PXA5 UniProtKB Repeat 270 299 . . . Note=ANK 2;Ontology_term=ECO:0000255;evidence=ECO:0000255 A0A1D5PXA5 UniProtKB Repeat 355 387 . . . Note=ANK 3;Ontology_term=ECO:0000255;evidence=ECO:0000255 A0A1D5PXA5 UniProtKB Region 30 51 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite A0A1D5PXA5 UniProtKB Motif 665 668 . . . Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35433 A0A1D5PXA5 UniProtKB Binding site 178 178 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HBA0 A0A1D5PXA5 UniProtKB Binding site 183 183 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HBA0 A0A1D5PXA5 UniProtKB Binding site 187 187 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HBA0 A0A1D5PXA5 UniProtKB Binding site 222 225 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HBA0 A0A1D5PXA5 UniProtKB Binding site 234 234 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HBA0 A0A1D5PXA5 UniProtKB Binding site 235 237 . . . Ontology_term=ECO:0000305,ECO:0007744;evidence=ECO:0000305|PubMed:25256292,ECO:0007744|PDB:3W9F;Dbxref=PMID:25256292 A0A1D5PXA5 UniProtKB Binding site 282 285 . . . Ontology_term=ECO:0000305,ECO:0007744;evidence=ECO:0000305|PubMed:25256292,ECO:0007744|PDB:3W9F;Dbxref=PMID:25256292 A0A1D5PXA5 UniProtKB Binding site 330 330 . . . Ontology_term=ECO:0000305,ECO:0007744;evidence=ECO:0000305|PubMed:25256292,ECO:0007744|PDB:3W9F;Dbxref=PMID:25256292 A0A1D5PXA5 UniProtKB Binding site 668 668 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R186 A0A1D5PXA5 UniProtKB Mutagenesis 178 178 . . . Note=Strongly decreased affinity for ATP and Ca(2+)-calmodulin. Abolishes ATP-mediated increase in channel sensitivity to agonists. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19864432;Dbxref=PMID:19864432 A0A1D5PXA5 UniProtKB Mutagenesis 183 183 . . . Note=Strongly decreased affinity for ATP and slightly decreased affinity for Ca(2+)-calmodulin. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19864432;Dbxref=PMID:19864432 A0A1D5PXA5 UniProtKB Mutagenesis 205 205 . . . Note=No significant effect on affinity for ATP and Ca(2+)-calmodulin. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19864432;Dbxref=PMID:19864432 A0A1D5PXA5 UniProtKB Sequence conflict 47 47 . . . Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 A0A1D5PXA5 UniProtKB Sequence conflict 131 131 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 A0A1D5PXA5 UniProtKB Sequence conflict 741 741 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 A0A1D5PXA5 UniProtKB Beta strand 131 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6F55 A0A1D5PXA5 UniProtKB Helix 137 146 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 149 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 155 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 169 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Turn 174 176 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 180 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Beta strand 189 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3JXJ A0A1D5PXA5 UniProtKB Helix 195 205 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 209 214 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Beta strand 220 225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 227 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 237 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Beta strand 260 262 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 274 280 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 284 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 310 317 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 322 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 348 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 359 365 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F A0A1D5PXA5 UniProtKB Helix 369 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3W9F