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Q9DFS3

- Q9DFS3_CHICK

UniProt

Q9DFS3 - Q9DFS3_CHICK

Protein
Submitted name:

Vanilloid receptor-related osmotically activated channel protein

Gene

VR-OAC

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561Phosphate; via amide nitrogenImported
    Binding sitei267 – 2671PhosphateImported
    Binding sitei272 – 2721PhosphateImported

    GO - Molecular functioni

    1. calmodulin binding Source: UniProtKB
    2. cation channel activity Source: UniProtKB

    GO - Biological processi

    1. cation transport Source: GOC
    2. cellular calcium ion homeostasis Source: UniProtKB

    Keywords - Molecular functioni

    Ion channelUniRule annotation, ReceptorImported

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Vanilloid receptor-related osmotically activated channel proteinImported
    Gene namesi
    Name:VR-OACImported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PaxDbiQ9DFS3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000022441.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JXIX-ray2.30A/B/C/D133-382[»]
    3JXJX-ray2.80A/B133-382[»]
    3W9FX-ray1.90A/B/C/D133-382[»]
    3W9GX-ray2.00A/B/C/D133-382[»]
    ProteinModelPortaliQ9DFS3.
    SMRiQ9DFS3. Positions 135-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9DFS3.

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotationSAAS annotation, RepeatUniRule annotation, TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiNOG278734.
    HOGENOMiHOG000234630.
    HOVERGENiHBG054085.
    InParanoidiQ9DFS3.
    KOiK04973.
    PhylomeDBiQ9DFS3.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008347. TRPV1-4_channel.
    IPR008348. TRPV4_channel.
    [Graphical view]
    PANTHERiPTHR10582:SF4. PTHR10582:SF4. 1 hit.
    PfamiPF00023. Ank. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01768. TRPVRECEPTOR.
    PR01769. VRL2RECEPTOR.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DFS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPEDPRDA GDVLGDDSFP LSSLANLFEV EDTPSPAEPS RGPPGAGDGK    50
    QNLRMKFHGA FRKGPPKPME LLESTIYESS VVPAPKKAPM DSLFDYGTYR 100
    QHPSENKRWR RRVVEKPVAG TKGPAPNPPP VLKVFNRPIL FDIVSRGSPD 150
    GLEGLLSFLL THKKRLTDEE FREPSTGKTC LPKALLNLSA GRNDTIPILL 200
    DIAEKTGNMR EFINSPFRDV YYRGQTALHI AIERRCKHYV ELLVEKGADV 250
    HAQARGRFFQ PKDEGGYFYF GELPLSLAAC TNQPHIVHYL TENGHKQADL 300
    RRQDSRGNTV LHALVAIADN TRENTKFVTK MYDLLLIKCA KLFPDTNLEA 350
    LLNNDGLSPL MMAAKTGKIG IFQHIIRREI ADEDVRHLSR KFKDWAYGPV 400
    YSSLYDLSSL DTCGEEVSVL EILVYNSKIE NRHEMLAVEP INELLRDKWR 450
    KFGAVSFYIS VVSYLCAMII FTLIAYYRPM EGPPPYPYTT TIDYLRLAGE 500
    IITLLTGILF FFSNIKDLFM KKCPGVNSFF IDGSFQLLYF IYSVLVIVTA 550
    GLYLGGVEAY LAVMVFALVL GWMNALYFTR GLKLTGTYSI MIQKILFKDL 600
    FRFLLVYLLF MIGYASALVS LLNPCPSSES CSEDHSNCTL PTYPSCRDSQ 650
    TFSTFLLDLF KLTIGMGDLE MLESAKYPGV FIILLVTYII LTFVLLLNML 700
    IALMGETVGQ VSKESKHIWK LQWATTILDI ERSFPLFLRR AFRSGEMVTV 750
    GKGTDGTPDR RWCFRVDEVN WSHWNQNLGI ISEDPGKSDT YQYYGFSHTV 800
    GRLRRDRWST VVPRVVELNK SCPTEDVVVP LGTMGTAEAR ERRHGQTPSS 850
    PL 852
    Length:852
    Mass (Da):96,198
    Last modified:March 1, 2001 - v1
    Checksum:iE85365D3FADD08C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261883 mRNA. Translation: AAG28026.1.
    RefSeqiNP_990023.1. NM_204692.1.
    UniGeneiGga.51246.

    Genome annotation databases

    GeneIDi395427.
    KEGGigga:395427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261883 mRNA. Translation: AAG28026.1 .
    RefSeqi NP_990023.1. NM_204692.1.
    UniGenei Gga.51246.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JXI X-ray 2.30 A/B/C/D 133-382 [» ]
    3JXJ X-ray 2.80 A/B 133-382 [» ]
    3W9F X-ray 1.90 A/B/C/D 133-382 [» ]
    3W9G X-ray 2.00 A/B/C/D 133-382 [» ]
    ProteinModelPortali Q9DFS3.
    SMRi Q9DFS3. Positions 135-380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000022441.

    Proteomic databases

    PaxDbi Q9DFS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395427.
    KEGGi gga:395427.

    Organism-specific databases

    CTDi 59341.

    Phylogenomic databases

    eggNOGi NOG278734.
    HOGENOMi HOG000234630.
    HOVERGENi HBG054085.
    InParanoidi Q9DFS3.
    KOi K04973.
    PhylomeDBi Q9DFS3.

    Miscellaneous databases

    EvolutionaryTracei Q9DFS3.
    NextBioi 20815511.
    PROi Q9DFS3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008347. TRPV1-4_channel.
    IPR008348. TRPV4_channel.
    [Graphical view ]
    PANTHERi PTHR10582:SF4. PTHR10582:SF4. 1 hit.
    Pfami PF00023. Ank. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01768. TRPVRECEPTOR.
    PR01769. VRL2RECEPTOR.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor."
      Liedtke W.B., Choe Y., Marti-Renom M.A., Bell A.M., Denis C.S., Sali A., Hudspeth A.J., Friedman J.M., Heller S.
      Cell 103:525-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: CochleaImported.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 133-382.
    3. "Vanilloid receptor-related osmotically activated channel protein."
      Hamada-Nakahara S., Takahashi N., Itoh Y., Shimada A., Takemura K., Ueda Y., Kiyonaka S., Kohda D., Kitao A., Mori Y., Suetsugu S.
      Submitted (APR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 133-382.

    Entry informationi

    Entry nameiQ9DFS3_CHICK
    AccessioniPrimary (citable) accession number: Q9DFS3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3