Vanilloid receptor-related osmotically activated channel protein - Gallus gallus (Chicken)

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Q9DFS3 (Q9DFS3_CHICK) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 76. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Vanilloid receptor-related osmotically activated channel protein EMBL AAG28026.1

Gene names

Name:

VR-OAC EMBL AAG28026.1

Organism

Gallus gallus (Chicken) EMBL AAG28026.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	ANK repeat RuleBase RU003321 SAAS SAAS005821 Repeat RuleBase RU003536 Transmembrane RuleBase RU003378
Molecular function	Ion channel RuleBase RU003378 Receptor EMBL AAG28026.1
Technical term	3D-structure PDB 3JXJ PDB 3JXI
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	calmodulin binding Inferred from sequence or structural similarity. Source: UniProtKB cation channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9DFS3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: E85365D3FADD08C1
Show »

852

96,198

        10         20         30         40         50         60 
MADPEDPRDA GDVLGDDSFP LSSLANLFEV EDTPSPAEPS RGPPGAGDGK QNLRMKFHGA 

        70         80         90        100        110        120 
FRKGPPKPME LLESTIYESS VVPAPKKAPM DSLFDYGTYR QHPSENKRWR RRVVEKPVAG 

       130        140        150        160        170        180 
TKGPAPNPPP VLKVFNRPIL FDIVSRGSPD GLEGLLSFLL THKKRLTDEE FREPSTGKTC 

       190        200        210        220        230        240 
LPKALLNLSA GRNDTIPILL DIAEKTGNMR EFINSPFRDV YYRGQTALHI AIERRCKHYV 

       250        260        270        280        290        300 
ELLVEKGADV HAQARGRFFQ PKDEGGYFYF GELPLSLAAC TNQPHIVHYL TENGHKQADL 

       310        320        330        340        350        360 
RRQDSRGNTV LHALVAIADN TRENTKFVTK MYDLLLIKCA KLFPDTNLEA LLNNDGLSPL 

       370        380        390        400        410        420 
MMAAKTGKIG IFQHIIRREI ADEDVRHLSR KFKDWAYGPV YSSLYDLSSL DTCGEEVSVL 

       430        440        450        460        470        480 
EILVYNSKIE NRHEMLAVEP INELLRDKWR KFGAVSFYIS VVSYLCAMII FTLIAYYRPM 

       490        500        510        520        530        540 
EGPPPYPYTT TIDYLRLAGE IITLLTGILF FFSNIKDLFM KKCPGVNSFF IDGSFQLLYF 

       550        560        570        580        590        600 
IYSVLVIVTA GLYLGGVEAY LAVMVFALVL GWMNALYFTR GLKLTGTYSI MIQKILFKDL 

       610        620        630        640        650        660 
FRFLLVYLLF MIGYASALVS LLNPCPSSES CSEDHSNCTL PTYPSCRDSQ TFSTFLLDLF 

       670        680        690        700        710        720 
KLTIGMGDLE MLESAKYPGV FIILLVTYII LTFVLLLNML IALMGETVGQ VSKESKHIWK 

       730        740        750        760        770        780 
LQWATTILDI ERSFPLFLRR AFRSGEMVTV GKGTDGTPDR RWCFRVDEVN WSHWNQNLGI 

       790        800        810        820        830        840 
ISEDPGKSDT YQYYGFSHTV GRLRRDRWST VVPRVVELNK SCPTEDVVVP LGTMGTAEAR 

       850 
ERRHGQTPSS PL

References

[1]

"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor."
Liedtke W.B., Choe Y., Marti-Renom M.A., Bell A.M., Denis C.S., Sali A., Hudspeth A.J., Friedman J.M., Heller S.
Cell 103:525-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Cochlea EMBL AAG28026.1.

[2]

"Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C."
Landoure G., Zdebik A.A., Martinez T.L., Burnett B.G., Stanescu H.C., Inada H., Shi Y., Taye A.A., Kong L., Munns C.H., Choo S.S., Phelps C.B., Paudel R., Houlden H., Ludlow C.L., Caterina M.J., Gaudet R., Kleta R., Fischbeck K.H., Sumner C.J.
Nat. Genet. 42:170-174(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 133-382.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF261883 mRNA. Translation: AAG28026.1.

IPI

IPI00590998.

RefSeq

NP_990023.1. NM_204692.1.

UniGene

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3JXI	X-ray	2.30	A/B/C/D	133-382	[»]
3JXJ	X-ray	2.80	A/B	133-382	[»]

ProteinModelPortal

SMR

Q9DFS3. Positions 135-380.

ModBase

Protein-protein interaction databases

STRING

9031.ENSGALP00000022441.
Q9DFS3.

Proteomic databases

PaxDb

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

GeneID

KEGG

Organism-specific databases

CTD

Phylogenomic databases

eggNOG

HOGENOM

HOVERGEN

InParanoid

KO

OrthoDB

Family and domain databases

Gene3D

1.25.40.20. 1 hit.

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR008348. TRPV4_channel.
IPR024862. TRPV_channel.
[Graphical view]

PANTHER

PTHR10582. PTHR10582. 1 hit.
PTHR10582:SF4. PTHR10582:SF4. 1 hit.

Pfam

PF00023. Ank. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]

PRINTS

PR01768. TRPVRECEPTOR.
PR01769. VRL2RECEPTOR.

SMART

SM00248. ANK. 3 hits.
[Graphical view]

SUPFAM

SSF48403. ANK. 1 hit.

TIGRFAMs

TIGR00870. trp. 1 hit.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

ProtoNet

Other

EvolutionaryTrace

NextBio

Entry information

Entry name

Q9DFS3_CHICK

Accession

Primary (citable) accession number: Q9DFS3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info