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Q9DFS3

- Q9DFS3_CHICK

UniProt

Q9DFS3 - Q9DFS3_CHICK

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Protein
Submitted name: Vanilloid receptor-related osmotically activated channel protein
Gene
VR-OAC
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei256 – 2561Phosphate; via amide nitrogenImported
Binding sitei267 – 2671PhosphateImported
Binding sitei272 – 2721PhosphateImported

GO - Molecular functioni

  1. calmodulin binding Source: UniProtKB
  2. cation channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cation transport Source: GOC
  2. cellular calcium ion homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Vanilloid receptor-related osmotically activated channel proteinImported
Gene namesi
Name:VR-OACImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9DFS3.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022441.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JXIX-ray2.30A/B/C/D133-382[»]
3JXJX-ray2.80A/B133-382[»]
3W9FX-ray1.90A/B/C/D133-382[»]
3W9GX-ray2.00A/B/C/D133-382[»]
ProteinModelPortaliQ9DFS3.
SMRiQ9DFS3. Positions 135-380.

Miscellaneous databases

EvolutionaryTraceiQ9DFS3.

Family & Domainsi

Sequence similaritiesi

Contains 3 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotations, RepeatUniRule annotation, TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiNOG278734.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ9DFS3.
KOiK04973.
PhylomeDBiQ9DFS3.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR008348. TRPV4_channel.
[Graphical view]
PANTHERiPTHR10582:SF4. PTHR10582:SF4. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
PR01769. VRL2RECEPTOR.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DFS3-1 [UniParc]FASTAAdd to Basket

« Hide

MADPEDPRDA GDVLGDDSFP LSSLANLFEV EDTPSPAEPS RGPPGAGDGK    50
QNLRMKFHGA FRKGPPKPME LLESTIYESS VVPAPKKAPM DSLFDYGTYR 100
QHPSENKRWR RRVVEKPVAG TKGPAPNPPP VLKVFNRPIL FDIVSRGSPD 150
GLEGLLSFLL THKKRLTDEE FREPSTGKTC LPKALLNLSA GRNDTIPILL 200
DIAEKTGNMR EFINSPFRDV YYRGQTALHI AIERRCKHYV ELLVEKGADV 250
HAQARGRFFQ PKDEGGYFYF GELPLSLAAC TNQPHIVHYL TENGHKQADL 300
RRQDSRGNTV LHALVAIADN TRENTKFVTK MYDLLLIKCA KLFPDTNLEA 350
LLNNDGLSPL MMAAKTGKIG IFQHIIRREI ADEDVRHLSR KFKDWAYGPV 400
YSSLYDLSSL DTCGEEVSVL EILVYNSKIE NRHEMLAVEP INELLRDKWR 450
KFGAVSFYIS VVSYLCAMII FTLIAYYRPM EGPPPYPYTT TIDYLRLAGE 500
IITLLTGILF FFSNIKDLFM KKCPGVNSFF IDGSFQLLYF IYSVLVIVTA 550
GLYLGGVEAY LAVMVFALVL GWMNALYFTR GLKLTGTYSI MIQKILFKDL 600
FRFLLVYLLF MIGYASALVS LLNPCPSSES CSEDHSNCTL PTYPSCRDSQ 650
TFSTFLLDLF KLTIGMGDLE MLESAKYPGV FIILLVTYII LTFVLLLNML 700
IALMGETVGQ VSKESKHIWK LQWATTILDI ERSFPLFLRR AFRSGEMVTV 750
GKGTDGTPDR RWCFRVDEVN WSHWNQNLGI ISEDPGKSDT YQYYGFSHTV 800
GRLRRDRWST VVPRVVELNK SCPTEDVVVP LGTMGTAEAR ERRHGQTPSS 850
PL 852
Length:852
Mass (Da):96,198
Last modified:March 1, 2001 - v1
Checksum:iE85365D3FADD08C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261883 mRNA. Translation: AAG28026.1.
RefSeqiNP_990023.1. NM_204692.1.
UniGeneiGga.51246.

Genome annotation databases

GeneIDi395427.
KEGGigga:395427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261883 mRNA. Translation: AAG28026.1 .
RefSeqi NP_990023.1. NM_204692.1.
UniGenei Gga.51246.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3JXI X-ray 2.30 A/B/C/D 133-382 [» ]
3JXJ X-ray 2.80 A/B 133-382 [» ]
3W9F X-ray 1.90 A/B/C/D 133-382 [» ]
3W9G X-ray 2.00 A/B/C/D 133-382 [» ]
ProteinModelPortali Q9DFS3.
SMRi Q9DFS3. Positions 135-380.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000022441.

Proteomic databases

PaxDbi Q9DFS3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395427.
KEGGi gga:395427.

Organism-specific databases

CTDi 59341.

Phylogenomic databases

eggNOGi NOG278734.
HOGENOMi HOG000234630.
HOVERGENi HBG054085.
InParanoidi Q9DFS3.
KOi K04973.
PhylomeDBi Q9DFS3.

Miscellaneous databases

EvolutionaryTracei Q9DFS3.
NextBioi 20815511.
PROi Q9DFS3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR008348. TRPV4_channel.
[Graphical view ]
PANTHERi PTHR10582:SF4. PTHR10582:SF4. 1 hit.
Pfami PF00023. Ank. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR01768. TRPVRECEPTOR.
PR01769. VRL2RECEPTOR.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor."
    Liedtke W.B., Choe Y., Marti-Renom M.A., Bell A.M., Denis C.S., Sali A., Hudspeth A.J., Friedman J.M., Heller S.
    Cell 103:525-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: CochleaImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 133-382 IN COMPLEX WITH PHOSPHATE.
  3. "Vanilloid receptor-related osmotically activated channel protein."
    Hamada-Nakahara S., Takahashi N., Itoh Y., Shimada A., Takemura K., Ueda Y., Kiyonaka S., Kohda D., Kitao A., Mori Y., Suetsugu S.
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 133-382.

Entry informationi

Entry nameiQ9DFS3_CHICK
AccessioniPrimary (citable) accession number: Q9DFS3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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