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Protein

Sodium channel protein

Gene

scn8aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  • voltage-gated sodium channel activity Source: ZFIN

GO - Biological processi

  • larval locomotory behavior Source: ZFIN
  • mechanosensory behavior Source: ZFIN
  • membrane depolarization during action potential Source: GO_Central
  • motor neuron axon guidance Source: ZFIN
  • neuronal action potential Source: GO_Central
  • sodium ion transmembrane transport Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:scn8aaImported
Synonyms:scn8aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-000828-1. scn8aa.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 151HelicalUniRule annotationAdd BLAST24
Transmembranei196 – 215HelicalUniRule annotationAdd BLAST20
Transmembranei227 – 248HelicalUniRule annotationAdd BLAST22
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei349 – 368HelicalUniRule annotationAdd BLAST20
Transmembranei388 – 415HelicalUniRule annotationAdd BLAST28
Transmembranei723 – 741HelicalUniRule annotationAdd BLAST19
Transmembranei753 – 771HelicalUniRule annotationAdd BLAST19
Transmembranei833 – 861HelicalUniRule annotationAdd BLAST29
Transmembranei920 – 946HelicalUniRule annotationAdd BLAST27
Transmembranei1168 – 1186HelicalUniRule annotationAdd BLAST19
Transmembranei1207 – 1226HelicalUniRule annotationAdd BLAST20
Transmembranei1238 – 1258HelicalUniRule annotationAdd BLAST21
Transmembranei1284 – 1310HelicalUniRule annotationAdd BLAST27
Transmembranei1407 – 1433HelicalUniRule annotationAdd BLAST27
Transmembranei1492 – 1510HelicalUniRule annotationAdd BLAST19
Transmembranei1522 – 1544HelicalUniRule annotationAdd BLAST23
Transmembranei1556 – 1575HelicalUniRule annotationAdd BLAST20
Transmembranei1619 – 1645HelicalUniRule annotationAdd BLAST27
Transmembranei1712 – 1735HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

  • integral component of plasma membrane Source: ZFIN
  • plasma membrane Source: GO_Central
  • voltage-gated sodium channel complex Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000005775.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024690.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 422Ion_transInterPro annotationAdd BLAST292
Domaini498 – 671Na_trans_cytoplInterPro annotationAdd BLAST174
Domaini723 – 950Ion_transInterPro annotationAdd BLAST228
Domaini960 – 1161Na_trans_assocInterPro annotationAdd BLAST202
Domaini1166 – 1441Ion_transInterPro annotationAdd BLAST276
Domaini1491 – 1745Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili412 – 450Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04840.
OMAiVIWPINT.
OrthoDBiEOG091G00FK.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008054. Na_channel_a8su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01667. NACHANNEL8.

Sequencei

Sequence statusi: Complete.

Q9DF53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPLLAPPG PNSYKYFTRE SLREIEKRIE EEKAKPPPKP DNSYRDDDDE
60 70 80 90 100
NKPKPNGDLE AGKSLPFIYG DIPPGMVATP LEDFDPFYIN QKTFVVLNKG
110 120 130 140 150
KTIFRFSATP ALYMISPFNL ARRIAIKILI HSVFSMFIMC TILTNCVFMT
160 170 180 190 200
FSNPPEWSKQ VEYTFTGIYT FESAVKIIAR GFCIDGFTFL RDPWNWLDFM
210 220 230 240 250
VISMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
260 270 280 290 300
LSDVMILTVF CLSVFALIGL QLFMGNLRQK CVIWPINITE MFPDVNGSRA
310 320 330 340 350
FNWDEYILNE TNFYFLPDQL DALLCGNSSD SGRCPEGYTC MKAGRNPNYG
360 370 380 390 400
YTSFDSFGWA FLALFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFVGS
410 420 430 440 450
FYLVNLILAV VAMAYEEQNQ ATMEEAERKE AEFKAMLEQL KKQQEDAQAN
460 470 480 490 500
AMATSAGTVS EDVVEDDGDG EGNLSCSSSE MSKLSSKSAK ERRNRKKKWR
510 520 530 540 550
QKEQDKEKGD SEKFVKSESD DGSRRRFRFP DNRLGRRSSI MNQSLLSIPG
560 570 580 590 600
SPFPSRRNSK SSIFSRCKDG GSENEFADDE HSTVEEYDER RDSFLSPQRR
610 620 630 640 650
SSYTGFYGKR NSTVDCNGVV SLIGPGPGGR LLPEPTTDLE IKKKLSGSLM
660 670 680 690 700
VSVEQLNTSF GRKERANSVM SALTNTLVEE LEESQRKCPP CWYKFANTFL
710 720 730 740 750
IWECGPLWMS IKEIVNLIVM DPFVDLAITI CIVLNTLFMA MEHYPMTPQF
760 770 780 790 800
EHVLSVGNLV FTGIFTAEMF AKLVAMDPYY YFQEGWNIFD GFIVSLSLME
810 820 830 840 850
LGLANVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
860 870 880 890 900
LAIIVFIFAV VGMQLFGKSY KDCVCKIAQD CELPRWHMND FFHSFLIVFR
910 920 930 940 950
VLCGEWIETM WDCMEVAGQA MCLIVFMMVM VIGNLVVLNL FLALLLSSFS
960 970 980 990 1000
ADNLAASDDD GEMNNLQIAV IRIKKGIAWV KAKVRELVNI ILGRKVTDEA
1010 1020 1030 1040 1050
KPLDDMYDRK LNCIANHTGV DISRDLDYQK NGNGTTSGIG SSVGKYMIDD
1060 1070 1080 1090 1100
DHMSFIHNPN LTVCVPIAVG ESDFENLNTE DFSSESEAEG SKELDDISSS
1110 1120 1130 1140 1150
EGSTIDIKPE VEEAVVVETV EEYVDPEACW TEACIARYKC CDVPITEGWG
1160 1170 1180 1190 1200
KNWWFLRKTC YLIVEHNWFE TLIIFMILLS SGALAFEDVY IEQRKTIRII
1210 1220 1230 1240 1250
LEYADMVFTY IFILEMLLKW VAYGFVKYFT NAWCWLDFFI VDVSIVSLIA
1260 1270 1280 1290 1300
NALGYSDLGP IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL
1310 1320 1330 1340 1350
LVCLIFWLIF SIMGVNMFAG KYYYCYNETE KAYFELDVVN NKSECFALIE
1360 1370 1380 1390 1400
QNYTEVRWKN VKINFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRRVEDQ
1410 1420 1430 1440 1450
PKYEDNIYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM
1460 1470 1480 1490 1500
TEEQKKYYNA MKKLGSKKPQ KPIPRPQNKL QGMVFDFVTQ QVFDISIMIL
1510 1520 1530 1540 1550
ICLNMVTMMV ETDDQSQETE NILYWINFIF IVAFTSEFVL KLFALRHYYF
1560 1570 1580 1590 1600
TNGWNIFDCV VVILSIVGMF LADLIEKYFV SPTLFRVIRL ARIGRILRLI
1610 1620 1630 1640 1650
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIFSIFGMS NFAYVKRESG
1660 1670 1680 1690 1700
IDDMYNFETF GNSMICLFMI TTSAGWDGLL APILNYPPDC EPTKENPGTS
1710 1720 1730 1740 1750
VKGNCGNPSV GIFFFVMYII VSFLIVVNMY IAIILENFSV ATEESADPLC
1760 1770 1780 1790 1800
EDDFESFYEI WEKFDPTASQ FITFAKLGDF ADTLEHPLRV PKPNTIELIA
1810 1820 1830 1840 1850
MDLPMVSGDR IHCLDILFAF TKRVLGDSGD LDMMRQQMEE RFIAANPSKV
1860 1870 1880 1890 1900
SFEPITTTLR RKQEHMSAGV IQRAFRAHLI RKGFICKRLL SSSRLENGGT
1910 1920 1930 1940
NQDKKEGTPS TASLPSYDSV TKPEKEKLEE SDSKGKKGKN QKDVKESKF
Length:1,949
Mass (Da):221,762
Last modified:March 1, 2001 - v1
Checksum:i6BCA69664BDC7BC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376824 Genomic DNA. No translation available.
AF297658 mRNA. Translation: AAG18440.1.
RefSeqiNP_571703.1. NM_131628.1.
UniGeneiDr.82518.

Genome annotation databases

EnsembliENSDART00000022042; ENSDARP00000024690; ENSDARG00000005775.
GeneIDi58152.
KEGGidre:58152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376824 Genomic DNA. No translation available.
AF297658 mRNA. Translation: AAG18440.1.
RefSeqiNP_571703.1. NM_131628.1.
UniGeneiDr.82518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000022042; ENSDARP00000024690; ENSDARG00000005775.
GeneIDi58152.
KEGGidre:58152.

Organism-specific databases

CTDi58152.
ZFINiZDB-GENE-000828-1. scn8aa.

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04840.
OMAiVIWPINT.
OrthoDBiEOG091G00FK.
TreeFamiTF323985.

Gene expression databases

BgeeiENSDARG00000005775.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008054. Na_channel_a8su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01667. NACHANNEL8.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9DF53_DANRE
AccessioniPrimary (citable) accession number: Q9DF53
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.