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Protein
Submitted name:

Sodium channel protein Scn8a

Gene

scn8aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • voltage-gated sodium channel activity Source: ZFIN

GO - Biological processi

  • larval locomotory behavior Source: ZFIN
  • mechanosensory behavior Source: ZFIN
  • membrane depolarization during action potential Source: GO_Central
  • motor neuron axon guidance Source: ZFIN
  • neuronal action potential Source: GO_Central
  • sodium ion transmembrane transport Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium channel protein Scn8aImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:scn8aaImported
Synonyms:scn8aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-000828-1. scn8aa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei128 – 15124HelicalSequence analysisAdd
BLAST
Transmembranei196 – 21520HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24822HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST
Transmembranei349 – 36820HelicalSequence analysisAdd
BLAST
Transmembranei388 – 41528HelicalSequence analysisAdd
BLAST
Transmembranei723 – 74119HelicalSequence analysisAdd
BLAST
Transmembranei753 – 77119HelicalSequence analysisAdd
BLAST
Transmembranei833 – 86129HelicalSequence analysisAdd
BLAST
Transmembranei920 – 94627HelicalSequence analysisAdd
BLAST
Transmembranei1168 – 118619HelicalSequence analysisAdd
BLAST
Transmembranei1207 – 122620HelicalSequence analysisAdd
BLAST
Transmembranei1238 – 125821HelicalSequence analysisAdd
BLAST
Transmembranei1284 – 131027HelicalSequence analysisAdd
BLAST
Transmembranei1407 – 143327HelicalSequence analysisAdd
BLAST
Transmembranei1492 – 151019HelicalSequence analysisAdd
BLAST
Transmembranei1522 – 154423HelicalSequence analysisAdd
BLAST
Transmembranei1556 – 157520HelicalSequence analysisAdd
BLAST
Transmembranei1619 – 164527HelicalSequence analysisAdd
BLAST
Transmembranei1712 – 173524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ZFIN
  • plasma membrane Source: GO_Central
  • voltage-gated sodium channel complex Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024690.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 422292Ion_transInterPro annotationAdd
BLAST
Domaini498 – 671174Na_trans_cytoplInterPro annotationAdd
BLAST
Domaini723 – 950228Ion_transInterPro annotationAdd
BLAST
Domaini960 – 1161202Na_trans_assocInterPro annotationAdd
BLAST
Domaini1166 – 1441276Ion_transInterPro annotationAdd
BLAST
Domaini1491 – 1745255Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili412 – 45039Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
OMAiVIWPINT.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008054. Na_channel_a8su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01667. NACHANNEL8.

Sequencei

Sequence statusi: Complete.

Q9DF53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPLLAPPG PNSYKYFTRE SLREIEKRIE EEKAKPPPKP DNSYRDDDDE
60 70 80 90 100
NKPKPNGDLE AGKSLPFIYG DIPPGMVATP LEDFDPFYIN QKTFVVLNKG
110 120 130 140 150
KTIFRFSATP ALYMISPFNL ARRIAIKILI HSVFSMFIMC TILTNCVFMT
160 170 180 190 200
FSNPPEWSKQ VEYTFTGIYT FESAVKIIAR GFCIDGFTFL RDPWNWLDFM
210 220 230 240 250
VISMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
260 270 280 290 300
LSDVMILTVF CLSVFALIGL QLFMGNLRQK CVIWPINITE MFPDVNGSRA
310 320 330 340 350
FNWDEYILNE TNFYFLPDQL DALLCGNSSD SGRCPEGYTC MKAGRNPNYG
360 370 380 390 400
YTSFDSFGWA FLALFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFVGS
410 420 430 440 450
FYLVNLILAV VAMAYEEQNQ ATMEEAERKE AEFKAMLEQL KKQQEDAQAN
460 470 480 490 500
AMATSAGTVS EDVVEDDGDG EGNLSCSSSE MSKLSSKSAK ERRNRKKKWR
510 520 530 540 550
QKEQDKEKGD SEKFVKSESD DGSRRRFRFP DNRLGRRSSI MNQSLLSIPG
560 570 580 590 600
SPFPSRRNSK SSIFSRCKDG GSENEFADDE HSTVEEYDER RDSFLSPQRR
610 620 630 640 650
SSYTGFYGKR NSTVDCNGVV SLIGPGPGGR LLPEPTTDLE IKKKLSGSLM
660 670 680 690 700
VSVEQLNTSF GRKERANSVM SALTNTLVEE LEESQRKCPP CWYKFANTFL
710 720 730 740 750
IWECGPLWMS IKEIVNLIVM DPFVDLAITI CIVLNTLFMA MEHYPMTPQF
760 770 780 790 800
EHVLSVGNLV FTGIFTAEMF AKLVAMDPYY YFQEGWNIFD GFIVSLSLME
810 820 830 840 850
LGLANVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
860 870 880 890 900
LAIIVFIFAV VGMQLFGKSY KDCVCKIAQD CELPRWHMND FFHSFLIVFR
910 920 930 940 950
VLCGEWIETM WDCMEVAGQA MCLIVFMMVM VIGNLVVLNL FLALLLSSFS
960 970 980 990 1000
ADNLAASDDD GEMNNLQIAV IRIKKGIAWV KAKVRELVNI ILGRKVTDEA
1010 1020 1030 1040 1050
KPLDDMYDRK LNCIANHTGV DISRDLDYQK NGNGTTSGIG SSVGKYMIDD
1060 1070 1080 1090 1100
DHMSFIHNPN LTVCVPIAVG ESDFENLNTE DFSSESEAEG SKELDDISSS
1110 1120 1130 1140 1150
EGSTIDIKPE VEEAVVVETV EEYVDPEACW TEACIARYKC CDVPITEGWG
1160 1170 1180 1190 1200
KNWWFLRKTC YLIVEHNWFE TLIIFMILLS SGALAFEDVY IEQRKTIRII
1210 1220 1230 1240 1250
LEYADMVFTY IFILEMLLKW VAYGFVKYFT NAWCWLDFFI VDVSIVSLIA
1260 1270 1280 1290 1300
NALGYSDLGP IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL
1310 1320 1330 1340 1350
LVCLIFWLIF SIMGVNMFAG KYYYCYNETE KAYFELDVVN NKSECFALIE
1360 1370 1380 1390 1400
QNYTEVRWKN VKINFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRRVEDQ
1410 1420 1430 1440 1450
PKYEDNIYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM
1460 1470 1480 1490 1500
TEEQKKYYNA MKKLGSKKPQ KPIPRPQNKL QGMVFDFVTQ QVFDISIMIL
1510 1520 1530 1540 1550
ICLNMVTMMV ETDDQSQETE NILYWINFIF IVAFTSEFVL KLFALRHYYF
1560 1570 1580 1590 1600
TNGWNIFDCV VVILSIVGMF LADLIEKYFV SPTLFRVIRL ARIGRILRLI
1610 1620 1630 1640 1650
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIFSIFGMS NFAYVKRESG
1660 1670 1680 1690 1700
IDDMYNFETF GNSMICLFMI TTSAGWDGLL APILNYPPDC EPTKENPGTS
1710 1720 1730 1740 1750
VKGNCGNPSV GIFFFVMYII VSFLIVVNMY IAIILENFSV ATEESADPLC
1760 1770 1780 1790 1800
EDDFESFYEI WEKFDPTASQ FITFAKLGDF ADTLEHPLRV PKPNTIELIA
1810 1820 1830 1840 1850
MDLPMVSGDR IHCLDILFAF TKRVLGDSGD LDMMRQQMEE RFIAANPSKV
1860 1870 1880 1890 1900
SFEPITTTLR RKQEHMSAGV IQRAFRAHLI RKGFICKRLL SSSRLENGGT
1910 1920 1930 1940
NQDKKEGTPS TASLPSYDSV TKPEKEKLEE SDSKGKKGKN QKDVKESKF
Length:1,949
Mass (Da):221,762
Last modified:March 1, 2001 - v1
Checksum:i6BCA69664BDC7BC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376824 Genomic DNA. No translation available.
AF297658 mRNA. Translation: AAG18440.1.
RefSeqiNP_571703.1. NM_131628.1.
UniGeneiDr.82518.

Genome annotation databases

EnsembliENSDART00000022042; ENSDARP00000024690; ENSDARG00000005775.
GeneIDi58152.
KEGGidre:58152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR376824 Genomic DNA. No translation available.
AF297658 mRNA. Translation: AAG18440.1.
RefSeqiNP_571703.1. NM_131628.1.
UniGeneiDr.82518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000022042; ENSDARP00000024690; ENSDARG00000005775.
GeneIDi58152.
KEGGidre:58152.

Organism-specific databases

CTDi58152.
ZFINiZDB-GENE-000828-1. scn8aa.

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
OMAiVIWPINT.
OrthoDBiEOG7DJSK9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR008054. Na_channel_a8su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01667. NACHANNEL8.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and differential expression during neurogenesis of a novel zebrafish sodium channel scn8a."
    Tsai C.-W., Tseng J.-J., Horng J.-F., Wu J.-L., Tsay H.-J.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: OregonImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9DF53_DANRE
AccessioniPrimary (citable) accession number: Q9DF53
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.