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Protein

Basic phospholipase A2 KPA2

Gene
N/A
Organism
Bungarus caeruleus (Indian krait)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Snake venom phospholipase A2 (PLA2) that shows anticoagulant and neurotoxic activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi55Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi57Calcium; via carbonyl oxygenCombined sources1 Publication1
Active sitei731 Publication1
Metal bindingi74CalciumCombined sources1 Publication1
Active sitei1191 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBlood coagulation cascade inhibiting toxin, Hemostasis impairing toxin, Hydrolase, Neurotoxin, Presynaptic neurotoxin, Toxin
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic phospholipase A2 KPA2 (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
OrganismiBungarus caeruleus (Indian krait)
Taxonomic identifieri132961 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeBungarinaeBungarus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002282720 – 27By similarity8
ChainiPRO_000002282828 – 145Basic phospholipase A2 KPA2Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97Combined sources1 Publication
Disulfide bondi52 ↔ 144Combined sources1 Publication
Disulfide bondi54 ↔ 70Combined sources1 Publication
Disulfide bondi69 ↔ 125Combined sources1 Publication
Disulfide bondi76 ↔ 118Combined sources1 Publication
Disulfide bondi86 ↔ 111Combined sources1 Publication
Disulfide bondi104 ↔ 116Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9DF52

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 39Combined sources11
Helixi44 – 47Combined sources4
Turni51 – 53Combined sources3
Beta strandi54 – 57Combined sources4
Helixi65 – 80Combined sources16
Turni88 – 90Combined sources3
Beta strandi95 – 98Combined sources4
Beta strandi101 – 104Combined sources4
Helixi110 – 128Combined sources19
Helixi133 – 135Combined sources3
Turni139 – 142Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DPYX-ray2.45A28-142[»]
1FE5X-ray2.45A28-145[»]
1PO8X-ray2.71A28-145[»]
ProteinModelPortaliQ9DF52
SMRiQ9DF52
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DF52

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DF52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPAHLLVLV AVCVSLLGAA NIPPQPLNLI QFKNMIQCAG TRPWTAYVNY
60 70 80 90 100
GCYCGKGGSG TPVDELDRCC YTHDNCYNEA EKIPGCNPNI KTYSYTCTEP
110 120 130 140
NLTCTDTADT CARFLCDCDR TAAICFASAP YNSNNVMISS STNCQ
Length:145
Mass (Da):15,765
Last modified:March 1, 2001 - v1
Checksum:i4CE49BD226AF3317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297663 mRNA Translation: AAG13412.1

Similar proteinsi

Entry informationi

Entry nameiPA2B_BUNCE
AccessioniPrimary (citable) accession number: Q9DF52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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