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Protein

Acidic phospholipase A2 2

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Snake venom phospholipase A2 (PLA2) that displays edema-inducing and moderate anticoagulant activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi55Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi57Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi59Calcium; via carbonyl oxygenCombined sources1 Publication1
Active sitei75By similarity1
Metal bindingi76CalciumCombined sources1 Publication1
Active sitei121By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBlood coagulation cascade inhibiting toxin, Hemostasis impairing toxin, Hydrolase, Toxin
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic phospholipase A2 2 (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
APLA2-2
Phosphatidylcholine 2-acylhydrolase
OrganismiOphiophagus hannah (King cobra) (Naja hannah)
Taxonomic identifieri8665 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002294422 – 27Sequence analysis6
ChainiPRO_000002294528 – 146Acidic phospholipase A2 2Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 99Combined sources1 Publication
Disulfide bondi54 ↔ 146Combined sources1 Publication
Disulfide bondi56 ↔ 72Combined sources1 Publication
Disulfide bondi71 ↔ 127Combined sources1 Publication
Disulfide bondi78 ↔ 120Combined sources1 Publication
Disulfide bondi88 ↔ 113Combined sources1 Publication
Disulfide bondi106 ↔ 118Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9DF33
TopDownProteomicsiQ9DF33

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 39Combined sources11
Helixi45 – 48Combined sources4
Beta strandi49 – 52Combined sources4
Turni53 – 55Combined sources3
Beta strandi56 – 59Combined sources4
Helixi67 – 81Combined sources15
Turni90 – 92Combined sources3
Beta strandi97 – 99Combined sources3
Beta strandi104 – 106Combined sources3
Helixi112 – 130Combined sources19
Helixi135 – 137Combined sources3
Helixi142 – 145Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M8TX-ray2.10A/B/C/D/E/F28-146[»]
ProteinModelPortaliQ9DF33
SMRiQ9DF33
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DF33

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DF33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPAHLLVLS AVCVSLLGAS SIPPQPLHLV QFNGMIRCTI PGSIPWWDYS
60 70 80 90 100
DYGCYCGSGG SGTPVDELDR CCQVHDNCYT QAQQLTECSP YSKRYSYDCS
110 120 130 140
EGTLTCKADN DECAAFVCDC DRVAAICFAG APYNKENINI DTTTRC
Length:146
Mass (Da):15,901
Last modified:March 1, 2001 - v1
Checksum:i354F45F6B67690A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302907 mRNA Translation: AAG23963.1

Similar proteinsi

Entry informationi

Entry nameiPA2A2_OPHHA
AccessioniPrimary (citable) accession number: Q9DF33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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