Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fatty acid desaturase 2

Gene

fads2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Fatty acid desaturase with both Delta5 and Delta6 activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3).By similarity

Catalytic activityi

Linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O.By similarity
Alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O.By similarity

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • liver development Source: ZFIN
  • unsaturated fatty acid biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Enzyme and pathway databases

BRENDAi1.14.19.3 928
UniPathwayiUPA00658

Chemistry databases

SwissLipidsiSLP:000000464

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid desaturase 2 (EC:1.14.19.3)
Alternative name(s):
Acyl-CoA 6-desaturase
Delta(5)/Delta(6) fatty acid desaturase
Short name:
D5D/D6D fatty acid desaturase
Short name:
Delta-5/Delta-6 fatty acid desaturase
Gene namesi
Name:fads2
Synonyms:fadsd6
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-011212-1 fads2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 130CytoplasmicSequence analysisAdd BLAST130
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 157LumenalSequence analysis6
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 264CytoplasmicSequence analysisAdd BLAST86
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 305LumenalSequence analysisAdd BLAST20
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 444CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854081 – 444Fatty acid desaturase 2Add BLAST444

Proteomic databases

PaxDbiQ9DEX7

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000022396

Structurei

3D structure databases

ProteinModelPortaliQ9DEX7
SMRiQ9DEX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 95Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi180 – 184Histidine box-15
Motifi217 – 221Histidine box-25
Motifi382 – 386Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4232 Eukaryota
ENOG410XVSZ LUCA
HOGENOMiHOG000012997
HOVERGENiHBG002839
InParanoidiQ9DEX7
KOiK10226
PhylomeDBiQ9DEX7

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR005804 FA_desaturase_dom
IPR012171 Fatty_acid_desaturase
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF015921 FA_sphinglp_des, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DEX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGGQQTDR ITDTNGRFSS YTWEEVQKHT KHGDQWVVVE RKVYNVSQWV
60 70 80 90 100
KRHPGGLRIL GHYAGEDATE AFTAFHPNLQ LVRKYLKPLL IGELEASEPS
110 120 130 140 150
QDRQKNAALV EDFRALRERL EAEGCFKTQP LFFALHLGHI LLLEAIAFMM
160 170 180 190 200
VWYFGTGWIN TLIVAVILAT AQSQAGWLQH DFGHLSVFKT SGMNHLVHKF
210 220 230 240 250
VIGHLKGASA GWWNHRHFQH HAKPNIFKKD PDVNMLNAFV VGNVQPVEYG
260 270 280 290 300
VKKIKHLPYN HQHKYFFFIG PPLLIPVYFQ FQIFHNMISH GMWVDLLWCI
310 320 330 340 350
SYYVRYFLCY TQFYGVFWAI ILFNFVRFME SHWFVWVTQM SHIPMNIDYE
360 370 380 390 400
KNQDWLSMQL VATCNIEQSA FNDWFSGHLN FQIEHHLFPT VPRHNYWRAA
410 420 430 440
PRVRALCEKY GVKYQEKTLY GAFADIIRSL EKSGELWLDA YLNK
Length:444
Mass (Da):52,032
Last modified:March 1, 2001 - v1
Checksum:i6AA25A1DC1DC0F65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26V → M in AAH49438 (Ref. 2) Curated1
Sequence conflicti82V → M in AAH49438 (Ref. 2) Curated1
Sequence conflicti149M → V in AAH49438 (Ref. 2) Curated1
Sequence conflicti342H → R in AAH49438 (Ref. 2) Curated1
Sequence conflicti351K → Q in AAH49438 (Ref. 2) Curated1
Sequence conflicti391V → M in AAH49438 (Ref. 2) Curated1
Sequence conflicti405A → S in AAH49438 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309556 mRNA Translation: AAG25710.1
BC049438 mRNA Translation: AAH49438.1
RefSeqiNP_571720.2, NM_131645.2
UniGeneiDr.75661

Genome annotation databases

GeneIDi140615
KEGGidre:140615

Similar proteinsi

Entry informationi

Entry nameiFADS2_DANRE
AccessioniPrimary (citable) accession number: Q9DEX7
Secondary accession number(s): Q7ZWF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health