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Protein
Submitted name:

Glycine receptor alphaZ2 subunit

Gene

glra4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: ZFIN
  • chloride transport Source: ZFIN
  • regulation of neuron differentiation Source: ZFIN
  • response to amino acid Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glycine receptor alphaZ2 subunitImported
Gene namesi
Name:glra4aImported
Synonyms:glyR alphaImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-010410-3. glra4a.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 3718HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27723HelicalSequence analysisAdd
BLAST
Transmembranei318 – 34124HelicalSequence analysisAdd
BLAST
Transmembranei423 – 44220HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ9DES9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000030826.

Structurei

3D structure databases

ProteinModelPortaliQ9DES9.
SMRiQ9DES9. Positions 282-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 253208Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini260 – 35495Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000231336.
HOVERGENiHBG051707.
KOiK05271.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008129. Glycine_rcpt_A2.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01675. GLYRALPHA2.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DES9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHFSLIITD CINCSFCHVY FSGFFSISLP LCFLYLWQKP MSPSDFLDKL
60 70 80 90 100
MGRTSGYDAR IRPNFKGPPV NVTCNIFINS FGSITETTMD YRLNVFLRQQ
110 120 130 140 150
WNDPRLAYSE YPDASLDLDP SMLDSIWKPD LFFANEKGAN FHEVTTDNKL
160 170 180 190 200
LRIFQNGNVL YSIRLTLILS CPMDLKNFPM DIQTCTMQLE SFGYTMNDLI
210 220 230 240 250
FEWLSDNPVQ VADDLTLPQF VLKEEKDLGY CTKHYNTGKF TCIEVKFHLE
260 270 280 290 300
RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVGLGI TTVLTMTTQS
310 320 330 340 350
SGSRASLPKV SYVKAIDIWM AVCLLIVFAA LLEYAAVNFV SRQHKEFIRL
360 370 380 390 400
RKKQRRQRIE EDLVRESRGF YFRGYGLGHC LQTKDGTAVE GSSVFAPPPP
410 420 430 440 450
VQVLYDGEAV RKRFVDRAKR IDTISRAVFP LSFLIFNVFY WITYKVLRHE

DIHANP
Length:456
Mass (Da):52,674
Last modified:March 1, 2001 - v1
Checksum:i62713B7F29999FBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404970 mRNA. Translation: CAC16687.1.
RefSeqiNP_571857.1. NM_131782.2.
UniGeneiDr.82595.

Genome annotation databases

GeneIDi83413.
KEGGidre:83413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404970 mRNA. Translation: CAC16687.1.
RefSeqiNP_571857.1. NM_131782.2.
UniGeneiDr.82595.

3D structure databases

ProteinModelPortaliQ9DES9.
SMRiQ9DES9. Positions 282-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000030826.

Proteomic databases

PaxDbiQ9DES9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83413.
KEGGidre:83413.

Organism-specific databases

CTDi83413.
ZFINiZDB-GENE-010410-3. glra4a.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000231336.
HOVERGENiHBG051707.
KOiK05271.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008129. Glycine_rcpt_A2.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01675. GLYRALPHA2.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and Characterization of a alpha 2-type zebrafish Glycine Receptor Subunit."
    Imboden M., de Saint Jan D., Leulier F., Korn H., Goblet C., Bregestovski P.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ9DES9_DANRE
AccessioniPrimary (citable) accession number: Q9DES9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.