SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9DER7

- TLL1_CHICK

UniProt

Q9DER7 - TLL1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tolloid-like protein 1
Gene
TLL1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi236 – 2361Zinc; catalytic By similarity
Active sitei237 – 2371 By similarity
Metal bindingi240 – 2401Zinc; catalytic By similarity
Metal bindingi246 – 2461Zinc; catalytic By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Tolloid-like protein 1 (EC:3.4.24.-)
Alternative name(s):
Chicken tolloid-like protein 1
Metalloprotease colloid
Gene namesi
Name:TLL1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Propeptidei27 – 143117 By similarity
PRO_0000046027Add
BLAST
Chaini144 – 1008865Tolloid-like protein 1
PRO_0000046028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi165 – 1651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi345 ↔ 371 By similarity
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi398 ↔ 420 By similarity
Disulfide bondi458 ↔ 484 By similarity
Disulfide bondi511 ↔ 533 By similarity
Disulfide bondi574 ↔ 585 By similarity
Disulfide bondi581 ↔ 594 By similarity
Disulfide bondi596 ↔ 609 By similarity
Disulfide bondi613 ↔ 639 By similarity
Glycosylationi621 – 6211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi666 ↔ 688 By similarity
Disulfide bondi729 ↔ 740 By similarity
Disulfide bondi736 ↔ 749 By similarity
Disulfide bondi751 ↔ 764 By similarity
Disulfide bondi769 ↔ 795 By similarity
Disulfide bondi822 ↔ 844 By similarity
Disulfide bondi882 ↔ 912 By similarity
Disulfide bondi939 ↔ 961 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9DER7.

Expressioni

Developmental stagei

Expressed at HH stage-10, with a restricted expression to the caudal notochord expanding between Hensen node and the last individualized somite. No expression in the ventral midline of the neural plate. The regionalized expression in the notochord persists at least until HH-stage 15. At HH stage-13, expression can be observed in the roof of the caudal diencephalon and expands, at HH stage-15, caudally to the mesencephalon.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015567.

Structurei

3D structure databases

ProteinModelPortaliQ9DER7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini345 – 457113CUB 1
Add
BLAST
Domaini458 – 570113CUB 2
Add
BLAST
Domaini570 – 61041EGF-like 1
Add
BLAST
Domaini613 – 725113CUB 3
Add
BLAST
Domaini725 – 76541EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini769 – 881113CUB 4
Add
BLAST
Domaini882 – 998117CUB 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 344201Metalloprotease By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.
Contains 5 CUB domains.
Contains 2 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG70307.
HOGENOMiHOG000236339.
HOVERGENiHBG004859.
InParanoidiQ9DER7.
KOiK09608.
PhylomeDBiQ9DER7.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DER7-1 [UniParc]FASTAAdd to Basket

« Hide

MKMLCWRLAL WLAAWAVCGK PSFCSALDYD YTYDFTEEDK AEAIDYKDPC     50
KAAVFWGDIA LDDEDLKIFQ IDRTIDLTQH SNERLGHNTG GFGEHGMSKK 100
RGALYQLIER IRRFGSGFEQ NNTSKGRTTV KFSGKNEKNR FPRAATSRTE 150
RIWPGGVIPY VIGGNFTGTQ RAMFKQAMRH WEKYTCVTFI ERSDEESYIV 200
FTYRPCGCCS YVGRRGNGPQ AISIGKNCDK FGIVVHELGH VIGFWHEHTR 250
PDRDDHVTII RENIQPGQEY NFLKMEPGEV NSLGEPYDFD SIMHYARNTF 300
SRGMFLDTIL PSRDDNGIRP AIGQRTRLSK GDIAQARKLY RCPACGETLQ 350
ESTGNFSSPG FPNGYPSYTH CIWRISVTPG EKIVLNFTTM DLYKSSLCWY 400
DYIEVRDGYW RKSPLLGRFC GDKLPEVLAS SDSRMWIEFR SSSNWVGKGF 450
AAVYEAICGG EIHKNEGQIQ SPNYPDDYRP MKECVWKITV SENYNVGLTF 500
QAFEIERHDN CAYDYLEIRD GMNENSPLIG HFCGYDKPED IRSTSNTLWM 550
KFVSDGTVNK AGFAANFFKE EMMCQPDNGG CEQRCVNTLG SYQCACDPGY 600
ELGPDKKSCE AACGGLLTKL NGTIPTPGWP KEYPPNKNCV WQVVAPTQYR 650
ISMKFEFFEL EGNEVCKYDY VEIRSGLSSD SKLHGKFCGT EVPEVITSQY 700
NNMRIEFRSD NTVSKKGFKA HFFSDKDECS KDNGGCQHEC INTVGSYVCQ 750
CRNGFVLHEN KHDCKEAECE QKIHSPNGII MSPNWPDKYP SRKECTWEIS 800
ATPGQRVKLT FNEFEIEQHQ ECAYDHLEVF DGESEKSPIL GRLCGSKIPE 850
PLIATGNKMF LRFISDASVQ RKGFQATHST ECGGRLKAET KPKDLYSHAQ 900
FGDNNYPVQA DCDWLLVAER GYRVELMFQT FEVEEEADCG YDYVELFDGH 950
DKTAMRLGRF CGSGPPEEIY SAGETLLLHF HTDDTINKKG FHIRYRSIKY 1000
PDSVHTKK 1008
Length:1,008
Mass (Da):114,891
Last modified:March 1, 2001 - v1
Checksum:i857A78A033B48413
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012462 mRNA. Translation: CAC08820.1.
RefSeqiNP_990034.1. NM_204703.1.
UniGeneiGga.239.

Genome annotation databases

GeneIDi395441.
KEGGigga:395441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ012462 mRNA. Translation: CAC08820.1 .
RefSeqi NP_990034.1. NM_204703.1.
UniGenei Gga.239.

3D structure databases

ProteinModelPortali Q9DER7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000015567.

Protein family/group databases

MEROPSi M12.016.

Proteomic databases

PaxDbi Q9DER7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395441.
KEGGi gga:395441.

Organism-specific databases

CTDi 7092.

Phylogenomic databases

eggNOGi NOG70307.
HOGENOMi HOG000236339.
HOVERGENi HBG004859.
InParanoidi Q9DER7.
KOi K09608.
PhylomeDBi Q9DER7.

Miscellaneous databases

NextBioi 20815525.
PROi Q9DER7.

Family and domain databases

Gene3Di 2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProi IPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view ]
Pfami PF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view ]
PIRSFi PIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSi PR00480. ASTACIN.
SMARTi SM00042. CUB. 5 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 5 hits.
PROSITEi PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification by differential display of a chicken tolloid-related metalloprotease specifically expressed in the caudal notochord."
    Liaubet L., Bertrand N., Medevielle F., Pituello F.
    Mech. Dev. 96:101-105(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTLL1_CHICK
AccessioniPrimary (citable) accession number: Q9DER7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi