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Q9DER7 (TLL1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tolloid-like protein 1

EC=3.4.24.-
Alternative name(s):
Chicken tolloid-like protein 1
Metalloprotease colloid
Gene names
Name:TLL1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1008 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted Ref.1.

Developmental stage

Expressed at HH stage-10, with a restricted expression to the caudal notochord expanding between Hensen node and the last individualized somite. No expression in the ventral midline of the neural plate. The regionalized expression in the notochord persists at least until HH-stage 15. At HH stage-13, expression can be observed in the roof of the caudal diencephalon and expands, at HH stage-15, caudally to the mesencephalon. Ref.1

Sequence similarities

Belongs to the peptidase M12A family.

Contains 5 CUB domains.

Contains 2 EGF-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 143117 By similarity
PRO_0000046027
Chain144 – 1008865Tolloid-like protein 1
PRO_0000046028

Regions

Domain345 – 457113CUB 1
Domain458 – 570113CUB 2
Domain570 – 61041EGF-like 1
Domain613 – 725113CUB 3
Domain725 – 76541EGF-like 2; calcium-binding Potential
Domain769 – 881113CUB 4
Domain882 – 998117CUB 5
Region144 – 344201Metalloprotease By similarity

Sites

Active site2371 By similarity
Metal binding2361Zinc; catalytic By similarity
Metal binding2401Zinc; catalytic By similarity
Metal binding2461Zinc; catalytic By similarity

Amino acid modifications

Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1651N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation3861N-linked (GlcNAc...) Potential
Glycosylation6211N-linked (GlcNAc...) Potential
Disulfide bond345 ↔ 371 By similarity
Disulfide bond398 ↔ 420 By similarity
Disulfide bond458 ↔ 484 By similarity
Disulfide bond511 ↔ 533 By similarity
Disulfide bond574 ↔ 585 By similarity
Disulfide bond581 ↔ 594 By similarity
Disulfide bond596 ↔ 609 By similarity
Disulfide bond613 ↔ 639 By similarity
Disulfide bond666 ↔ 688 By similarity
Disulfide bond729 ↔ 740 By similarity
Disulfide bond736 ↔ 749 By similarity
Disulfide bond751 ↔ 764 By similarity
Disulfide bond769 ↔ 795 By similarity
Disulfide bond822 ↔ 844 By similarity
Disulfide bond882 ↔ 912 By similarity
Disulfide bond939 ↔ 961 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9DER7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 857A78A033B48413

FASTA1,008114,891
        10         20         30         40         50         60 
MKMLCWRLAL WLAAWAVCGK PSFCSALDYD YTYDFTEEDK AEAIDYKDPC KAAVFWGDIA 

        70         80         90        100        110        120 
LDDEDLKIFQ IDRTIDLTQH SNERLGHNTG GFGEHGMSKK RGALYQLIER IRRFGSGFEQ 

       130        140        150        160        170        180 
NNTSKGRTTV KFSGKNEKNR FPRAATSRTE RIWPGGVIPY VIGGNFTGTQ RAMFKQAMRH 

       190        200        210        220        230        240 
WEKYTCVTFI ERSDEESYIV FTYRPCGCCS YVGRRGNGPQ AISIGKNCDK FGIVVHELGH 

       250        260        270        280        290        300 
VIGFWHEHTR PDRDDHVTII RENIQPGQEY NFLKMEPGEV NSLGEPYDFD SIMHYARNTF 

       310        320        330        340        350        360 
SRGMFLDTIL PSRDDNGIRP AIGQRTRLSK GDIAQARKLY RCPACGETLQ ESTGNFSSPG 

       370        380        390        400        410        420 
FPNGYPSYTH CIWRISVTPG EKIVLNFTTM DLYKSSLCWY DYIEVRDGYW RKSPLLGRFC 

       430        440        450        460        470        480 
GDKLPEVLAS SDSRMWIEFR SSSNWVGKGF AAVYEAICGG EIHKNEGQIQ SPNYPDDYRP 

       490        500        510        520        530        540 
MKECVWKITV SENYNVGLTF QAFEIERHDN CAYDYLEIRD GMNENSPLIG HFCGYDKPED 

       550        560        570        580        590        600 
IRSTSNTLWM KFVSDGTVNK AGFAANFFKE EMMCQPDNGG CEQRCVNTLG SYQCACDPGY 

       610        620        630        640        650        660 
ELGPDKKSCE AACGGLLTKL NGTIPTPGWP KEYPPNKNCV WQVVAPTQYR ISMKFEFFEL 

       670        680        690        700        710        720 
EGNEVCKYDY VEIRSGLSSD SKLHGKFCGT EVPEVITSQY NNMRIEFRSD NTVSKKGFKA 

       730        740        750        760        770        780 
HFFSDKDECS KDNGGCQHEC INTVGSYVCQ CRNGFVLHEN KHDCKEAECE QKIHSPNGII 

       790        800        810        820        830        840 
MSPNWPDKYP SRKECTWEIS ATPGQRVKLT FNEFEIEQHQ ECAYDHLEVF DGESEKSPIL 

       850        860        870        880        890        900 
GRLCGSKIPE PLIATGNKMF LRFISDASVQ RKGFQATHST ECGGRLKAET KPKDLYSHAQ 

       910        920        930        940        950        960 
FGDNNYPVQA DCDWLLVAER GYRVELMFQT FEVEEEADCG YDYVELFDGH DKTAMRLGRF 

       970        980        990       1000 
CGSGPPEEIY SAGETLLLHF HTDDTINKKG FHIRYRSIKY PDSVHTKK 

« Hide

References

[1]"Identification by differential display of a chicken tolloid-related metalloprotease specifically expressed in the caudal notochord."
Liaubet L., Bertrand N., Medevielle F., Pituello F.
Mech. Dev. 96:101-105(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ012462 mRNA. Translation: CAC08820.1.
RefSeqNP_990034.1. NM_204703.1.
UniGeneGga.239.

3D structure databases

ProteinModelPortalQ9DER7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000015567.

Protein family/group databases

MEROPSM12.016.

Proteomic databases

PaxDbQ9DER7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395441.
KEGGgga:395441.

Organism-specific databases

CTD7092.

Phylogenomic databases

eggNOGNOG70307.
HOGENOMHOG000236339.
HOVERGENHBG004859.
InParanoidQ9DER7.
KOK09608.
PhylomeDBQ9DER7.

Family and domain databases

Gene3D2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSPR00480. ASTACIN.
SMARTSM00042. CUB. 5 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMSSF49854. SSF49854. 5 hits.
PROSITEPS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815525.
PROQ9DER7.

Entry information

Entry nameTLL1_CHICK
AccessionPrimary (citable) accession number: Q9DER7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries