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Q9DER7

- TLL1_CHICK

UniProt

Q9DER7 - TLL1_CHICK

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Protein

Tolloid-like protein 1

Gene

TLL1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi236 – 2361Zinc; catalyticPROSITE-ProRule annotation
Active sitei237 – 2371PROSITE-ProRule annotation
Metal bindingi240 – 2401Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi246 – 2461Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Tolloid-like protein 1 (EC:3.4.24.-)
Alternative name(s):
Chicken tolloid-like protein 1
Metalloprotease colloid
Gene namesi
Name:TLL1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 143117By similarityPRO_0000046027Add
BLAST
Chaini144 – 1008865Tolloid-like protein 1PRO_0000046028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi345 ↔ 371By similarity
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi398 ↔ 420By similarity
Disulfide bondi458 ↔ 484By similarity
Disulfide bondi511 ↔ 533By similarity
Disulfide bondi574 ↔ 585By similarity
Disulfide bondi581 ↔ 594By similarity
Disulfide bondi596 ↔ 609By similarity
Disulfide bondi613 ↔ 639By similarity
Glycosylationi621 – 6211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi666 ↔ 688By similarity
Disulfide bondi729 ↔ 740By similarity
Disulfide bondi736 ↔ 749By similarity
Disulfide bondi751 ↔ 764By similarity
Disulfide bondi769 ↔ 795By similarity
Disulfide bondi822 ↔ 844By similarity
Disulfide bondi882 ↔ 912By similarity
Disulfide bondi939 ↔ 961By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9DER7.

Expressioni

Developmental stagei

Expressed at HH stage-10, with a restricted expression to the caudal notochord expanding between Hensen node and the last individualized somite. No expression in the ventral midline of the neural plate. The regionalized expression in the notochord persists at least until HH-stage 15. At HH stage-13, expression can be observed in the roof of the caudal diencephalon and expands, at HH stage-15, caudally to the mesencephalon.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015567.

Structurei

3D structure databases

ProteinModelPortaliQ9DER7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini345 – 457113CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini458 – 570113CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 61041EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini613 – 725113CUB 3PROSITE-ProRule annotationAdd
BLAST
Domaini725 – 76541EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini769 – 881113CUB 4PROSITE-ProRule annotationAdd
BLAST
Domaini882 – 998117CUB 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 344201MetalloproteaseBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 5 CUB domains.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG70307.
HOGENOMiHOG000236339.
HOVERGENiHBG004859.
InParanoidiQ9DER7.
KOiK09608.
PhylomeDBiQ9DER7.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DER7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMLCWRLAL WLAAWAVCGK PSFCSALDYD YTYDFTEEDK AEAIDYKDPC
60 70 80 90 100
KAAVFWGDIA LDDEDLKIFQ IDRTIDLTQH SNERLGHNTG GFGEHGMSKK
110 120 130 140 150
RGALYQLIER IRRFGSGFEQ NNTSKGRTTV KFSGKNEKNR FPRAATSRTE
160 170 180 190 200
RIWPGGVIPY VIGGNFTGTQ RAMFKQAMRH WEKYTCVTFI ERSDEESYIV
210 220 230 240 250
FTYRPCGCCS YVGRRGNGPQ AISIGKNCDK FGIVVHELGH VIGFWHEHTR
260 270 280 290 300
PDRDDHVTII RENIQPGQEY NFLKMEPGEV NSLGEPYDFD SIMHYARNTF
310 320 330 340 350
SRGMFLDTIL PSRDDNGIRP AIGQRTRLSK GDIAQARKLY RCPACGETLQ
360 370 380 390 400
ESTGNFSSPG FPNGYPSYTH CIWRISVTPG EKIVLNFTTM DLYKSSLCWY
410 420 430 440 450
DYIEVRDGYW RKSPLLGRFC GDKLPEVLAS SDSRMWIEFR SSSNWVGKGF
460 470 480 490 500
AAVYEAICGG EIHKNEGQIQ SPNYPDDYRP MKECVWKITV SENYNVGLTF
510 520 530 540 550
QAFEIERHDN CAYDYLEIRD GMNENSPLIG HFCGYDKPED IRSTSNTLWM
560 570 580 590 600
KFVSDGTVNK AGFAANFFKE EMMCQPDNGG CEQRCVNTLG SYQCACDPGY
610 620 630 640 650
ELGPDKKSCE AACGGLLTKL NGTIPTPGWP KEYPPNKNCV WQVVAPTQYR
660 670 680 690 700
ISMKFEFFEL EGNEVCKYDY VEIRSGLSSD SKLHGKFCGT EVPEVITSQY
710 720 730 740 750
NNMRIEFRSD NTVSKKGFKA HFFSDKDECS KDNGGCQHEC INTVGSYVCQ
760 770 780 790 800
CRNGFVLHEN KHDCKEAECE QKIHSPNGII MSPNWPDKYP SRKECTWEIS
810 820 830 840 850
ATPGQRVKLT FNEFEIEQHQ ECAYDHLEVF DGESEKSPIL GRLCGSKIPE
860 870 880 890 900
PLIATGNKMF LRFISDASVQ RKGFQATHST ECGGRLKAET KPKDLYSHAQ
910 920 930 940 950
FGDNNYPVQA DCDWLLVAER GYRVELMFQT FEVEEEADCG YDYVELFDGH
960 970 980 990 1000
DKTAMRLGRF CGSGPPEEIY SAGETLLLHF HTDDTINKKG FHIRYRSIKY

PDSVHTKK
Length:1,008
Mass (Da):114,891
Last modified:March 1, 2001 - v1
Checksum:i857A78A033B48413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012462 mRNA. Translation: CAC08820.1.
RefSeqiNP_990034.1. NM_204703.1.
UniGeneiGga.239.

Genome annotation databases

GeneIDi395441.
KEGGigga:395441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012462 mRNA. Translation: CAC08820.1 .
RefSeqi NP_990034.1. NM_204703.1.
UniGenei Gga.239.

3D structure databases

ProteinModelPortali Q9DER7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000015567.

Protein family/group databases

MEROPSi M12.016.

Proteomic databases

PaxDbi Q9DER7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395441.
KEGGi gga:395441.

Organism-specific databases

CTDi 7092.

Phylogenomic databases

eggNOGi NOG70307.
HOGENOMi HOG000236339.
HOVERGENi HBG004859.
InParanoidi Q9DER7.
KOi K09608.
PhylomeDBi Q9DER7.

Miscellaneous databases

NextBioi 20815525.
PROi Q9DER7.

Family and domain databases

Gene3Di 2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProi IPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view ]
Pfami PF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view ]
PIRSFi PIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSi PR00480. ASTACIN.
SMARTi SM00042. CUB. 5 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 5 hits.
PROSITEi PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification by differential display of a chicken tolloid-related metalloprotease specifically expressed in the caudal notochord."
    Liaubet L., Bertrand N., Medevielle F., Pituello F.
    Mech. Dev. 96:101-105(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTLL1_CHICK
AccessioniPrimary (citable) accession number: Q9DER7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3