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Q9DER7

- TLL1_CHICK

UniProt

Q9DER7 - TLL1_CHICK

Protein

Tolloid-like protein 1

Gene

TLL1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi236 – 2361Zinc; catalyticPROSITE-ProRule annotation
    Active sitei237 – 2371PROSITE-ProRule annotation
    Metal bindingi240 – 2401Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi246 – 2461Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM12.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tolloid-like protein 1 (EC:3.4.24.-)
    Alternative name(s):
    Chicken tolloid-like protein 1
    Metalloprotease colloid
    Gene namesi
    Name:TLL1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 143117By similarityPRO_0000046027Add
    BLAST
    Chaini144 – 1008865Tolloid-like protein 1PRO_0000046028Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi345 ↔ 371By similarity
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi398 ↔ 420By similarity
    Disulfide bondi458 ↔ 484By similarity
    Disulfide bondi511 ↔ 533By similarity
    Disulfide bondi574 ↔ 585By similarity
    Disulfide bondi581 ↔ 594By similarity
    Disulfide bondi596 ↔ 609By similarity
    Disulfide bondi613 ↔ 639By similarity
    Glycosylationi621 – 6211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi666 ↔ 688By similarity
    Disulfide bondi729 ↔ 740By similarity
    Disulfide bondi736 ↔ 749By similarity
    Disulfide bondi751 ↔ 764By similarity
    Disulfide bondi769 ↔ 795By similarity
    Disulfide bondi822 ↔ 844By similarity
    Disulfide bondi882 ↔ 912By similarity
    Disulfide bondi939 ↔ 961By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9DER7.

    Expressioni

    Developmental stagei

    Expressed at HH stage-10, with a restricted expression to the caudal notochord expanding between Hensen node and the last individualized somite. No expression in the ventral midline of the neural plate. The regionalized expression in the notochord persists at least until HH-stage 15. At HH stage-13, expression can be observed in the roof of the caudal diencephalon and expands, at HH stage-15, caudally to the mesencephalon.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000015567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DER7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini345 – 457113CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini458 – 570113CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini570 – 61041EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini613 – 725113CUB 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini725 – 76541EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini769 – 881113CUB 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini882 – 998117CUB 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni144 – 344201MetalloproteaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M12A family.Curated
    Contains 5 CUB domains.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG70307.
    HOGENOMiHOG000236339.
    HOVERGENiHBG004859.
    InParanoidiQ9DER7.
    KOiK09608.
    PhylomeDBiQ9DER7.

    Family and domain databases

    Gene3Di2.60.120.290. 5 hits.
    3.40.390.10. 1 hit.
    InterProiIPR015446. BMP_1/tolloid-like.
    IPR000859. CUB_dom.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001506. Peptidase_M12A.
    IPR006026. Peptidase_Metallo.
    [Graphical view]
    PfamiPF01400. Astacin. 1 hit.
    PF00431. CUB. 5 hits.
    [Graphical view]
    PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
    PRINTSiPR00480. ASTACIN.
    SMARTiSM00042. CUB. 5 hits.
    SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 1 hit.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 5 hits.
    PROSITEiPS01180. CUB. 5 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DER7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMLCWRLAL WLAAWAVCGK PSFCSALDYD YTYDFTEEDK AEAIDYKDPC     50
    KAAVFWGDIA LDDEDLKIFQ IDRTIDLTQH SNERLGHNTG GFGEHGMSKK 100
    RGALYQLIER IRRFGSGFEQ NNTSKGRTTV KFSGKNEKNR FPRAATSRTE 150
    RIWPGGVIPY VIGGNFTGTQ RAMFKQAMRH WEKYTCVTFI ERSDEESYIV 200
    FTYRPCGCCS YVGRRGNGPQ AISIGKNCDK FGIVVHELGH VIGFWHEHTR 250
    PDRDDHVTII RENIQPGQEY NFLKMEPGEV NSLGEPYDFD SIMHYARNTF 300
    SRGMFLDTIL PSRDDNGIRP AIGQRTRLSK GDIAQARKLY RCPACGETLQ 350
    ESTGNFSSPG FPNGYPSYTH CIWRISVTPG EKIVLNFTTM DLYKSSLCWY 400
    DYIEVRDGYW RKSPLLGRFC GDKLPEVLAS SDSRMWIEFR SSSNWVGKGF 450
    AAVYEAICGG EIHKNEGQIQ SPNYPDDYRP MKECVWKITV SENYNVGLTF 500
    QAFEIERHDN CAYDYLEIRD GMNENSPLIG HFCGYDKPED IRSTSNTLWM 550
    KFVSDGTVNK AGFAANFFKE EMMCQPDNGG CEQRCVNTLG SYQCACDPGY 600
    ELGPDKKSCE AACGGLLTKL NGTIPTPGWP KEYPPNKNCV WQVVAPTQYR 650
    ISMKFEFFEL EGNEVCKYDY VEIRSGLSSD SKLHGKFCGT EVPEVITSQY 700
    NNMRIEFRSD NTVSKKGFKA HFFSDKDECS KDNGGCQHEC INTVGSYVCQ 750
    CRNGFVLHEN KHDCKEAECE QKIHSPNGII MSPNWPDKYP SRKECTWEIS 800
    ATPGQRVKLT FNEFEIEQHQ ECAYDHLEVF DGESEKSPIL GRLCGSKIPE 850
    PLIATGNKMF LRFISDASVQ RKGFQATHST ECGGRLKAET KPKDLYSHAQ 900
    FGDNNYPVQA DCDWLLVAER GYRVELMFQT FEVEEEADCG YDYVELFDGH 950
    DKTAMRLGRF CGSGPPEEIY SAGETLLLHF HTDDTINKKG FHIRYRSIKY 1000
    PDSVHTKK 1008
    Length:1,008
    Mass (Da):114,891
    Last modified:March 1, 2001 - v1
    Checksum:i857A78A033B48413
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ012462 mRNA. Translation: CAC08820.1.
    RefSeqiNP_990034.1. NM_204703.1.
    UniGeneiGga.239.

    Genome annotation databases

    GeneIDi395441.
    KEGGigga:395441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ012462 mRNA. Translation: CAC08820.1 .
    RefSeqi NP_990034.1. NM_204703.1.
    UniGenei Gga.239.

    3D structure databases

    ProteinModelPortali Q9DER7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000015567.

    Protein family/group databases

    MEROPSi M12.016.

    Proteomic databases

    PaxDbi Q9DER7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395441.
    KEGGi gga:395441.

    Organism-specific databases

    CTDi 7092.

    Phylogenomic databases

    eggNOGi NOG70307.
    HOGENOMi HOG000236339.
    HOVERGENi HBG004859.
    InParanoidi Q9DER7.
    KOi K09608.
    PhylomeDBi Q9DER7.

    Miscellaneous databases

    NextBioi 20815525.
    PROi Q9DER7.

    Family and domain databases

    Gene3Di 2.60.120.290. 5 hits.
    3.40.390.10. 1 hit.
    InterProi IPR015446. BMP_1/tolloid-like.
    IPR000859. CUB_dom.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001506. Peptidase_M12A.
    IPR006026. Peptidase_Metallo.
    [Graphical view ]
    Pfami PF01400. Astacin. 1 hit.
    PF00431. CUB. 5 hits.
    [Graphical view ]
    PIRSFi PIRSF001199. BMP_1/tolloid-like. 1 hit.
    PRINTSi PR00480. ASTACIN.
    SMARTi SM00042. CUB. 5 hits.
    SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 1 hit.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 5 hits.
    PROSITEi PS01180. CUB. 5 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification by differential display of a chicken tolloid-related metalloprotease specifically expressed in the caudal notochord."
      Liaubet L., Bertrand N., Medevielle F., Pituello F.
      Mech. Dev. 96:101-105(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTLL1_CHICK
    AccessioniPrimary (citable) accession number: Q9DER7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3