Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ubiquitin activating enzyme

Gene

uba1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei633Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin activating enzymeImported
Gene namesi
Name:uba1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254676 uba1

Structurei

3D structure databases

ProteinModelPortaliQ9DEE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini923 – 1054UBA_e1_CInterPro annotationAdd BLAST132

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG054199
KOiK03178

Family and domain databases

Gene3Di3.10.290.60, 1 hit
InterProiView protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR035985 Ubiquitin-activating_enz
IPR018075 UBQ-activ_enz_E1
IPR018074 UBQ-activ_enz_E1_CS
IPR033127 UBQ-activ_enz_E1_Cys_AS
IPR000011 UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit
PRINTSiPR01849 UBIQUITINACT
SMARTiView protein in SMART
SM00985 UBA_e1_C, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
TIGRFAMsiTIGR01408 Ube1, 1 hit
PROSITEiView protein in PROSITE
PS00536 UBIQUITIN_ACTIVAT_1, 1 hit
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DEE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSPLSKKR RVSGSETKTG SNCSSSKSVS TDQPAPANGM ARNGNSTEID
60 70 80 90 100
EGLYSRQLYV LGHDAMKRMQ NSNVLISGMS GLGVEIAKNI ILAGVKSVTI
110 120 130 140 150
HDQHNTDWAD LSSQFYLRES DIGKNRAEVS HPRLAELNTY VPVSSSTDPL
160 170 180 190 200
TDEFMSAFQL VILTGSSLEE QLQVGDFCHS HDIKFIVADT KGLFGQLFCD
210 220 230 240 250
FGKEMVVMDP NGEQPLSAMI SMITKDNPGV VTCLDEARHG FETGDFVTFT
260 270 280 290 300
EVRGMTELNG CEPVEIKVLG PYTFSICDTS SFSDYIRGGI VSQVKMPKKI
310 320 330 340 350
SFKPLREALQ EADILITDFA KFDHPALLHL GFQGLHEFQK KHGHLPKAHN
360 370 380 390 400
EADALEVLAL TQAINENASG SSKQEEIKES LIKQLAYQAT GNLAPVNAFI
410 420 430 440 450
GGLAAQEAMK ACSGKFMPIM QWLYFDALEC LPEENADNTL TEETCSPKNS
460 470 480 490 500
RYDGQIAVFG SGFQEQLGKQ KYFLVGAGAI GCELLKNFAM IGLAAGDGGE
510 520 530 540 550
ITVTDMDTIE KSNLNRQFLF RPWDVTKMKS DTAAAAVKQM NPSLHITAHE
560 570 580 590 600
NRVGTETEKV YDDDFFEALD GVANALDNID ARMYMDRRCV YYRQPLLESG
610 620 630 640 650
TLGTKGNVQV VIPFLTESYS SSQDPPEKSI PICTLKNFPN AIEHTLQWAR
660 670 680 690 700
DEFEGLFKQP SENVNQYLTD PKFMERTLKL PGSQPLEVVE AVYKSLVMDR
710 720 730 740 750
PKSWADCVSW ASNHWHIQYS NNIRQLLHNF PPDQLTSAGV PFWSGPKRCP
760 770 780 790 800
HPLTFNASTG LHVDYIMAAA NLLASSYGIA GSKDRAAVVE ILRNLKVPEF
810 820 830 840 850
TPRSGVKIHV SDQEIQNAHA SLDDNRLEEL KHTLPTPESL GSFRMFPIDF
860 870 880 890 900
EKDDDTNFHM DFIVAASNLR AENYDIPPAD RHKSKLIAGK IIPAIATTTA
910 920 930 940 950
AVVGLVCLEL YKIIQGHRKL ESYKNGFLNL ALPFFGFSEP IAAPKHKYYD
960 970 980 990 1000
NEWTLWDRFE VKGVQSNGEE MTLKQFLDYF KDEHKLEITM LSQGVSMLYS
1010 1020 1030 1040 1050
FFMPAAKLKE RLEQPMTEIV TKVSKKKIGK HVKALVFELC CNDETDEDVE

VPYVRYTIR
Length:1,059
Mass (Da):117,968
Last modified:March 1, 2001 - v1
Checksum:iF8E0B540B1FC0D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040073 mRNA Translation: BAB19357.1
RefSeqiNP_001080185.1, NM_001086716.1
UniGeneiXl.3404

Genome annotation databases

GeneIDi379877
KEGGixla:379877

Similar proteinsi

Entry informationi

Entry nameiQ9DEE8_XENLA
AccessioniPrimary (citable) accession number: Q9DEE8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health