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Protein

Runt-related transcription factor

Gene

runx3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Chloride 1UniRule annotation1
Binding sitei113Chloride 1; via amide nitrogenUniRule annotation1
Binding sitei136Chloride 2UniRule annotation1
Binding sitei167Chloride 2; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: ZFIN
  • chondrocyte differentiation Source: GO_Central
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • hemopoiesis Source: ZFIN
  • neuron differentiation Source: GO_Central
  • ossification Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: UniProtKB-UniRule
  • regulation of cell differentiation Source: GO_Central
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-8941855. RUNX3 regulates CDKN1A transcription.
R-DRE-8941856. RUNX3 regulates NOTCH signaling.
R-DRE-8941858. Regulation of RUNX3 expression and activity.
R-DRE-8951430. RUNX3 regulates WNT signaling.
R-DRE-8951671. RUNX3 regulates YAP1-mediated transcription.
R-DRE-8951936. RUNX3 regulates p14-ARF.

Names & Taxonomyi

Protein namesi
Recommended name:
Runt-related transcription factorUniRule annotation
Gene namesi
Name:runx3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-000605-2. runx3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000052826.

Interactioni

Protein-protein interaction databases

ELMiQ9DEA0.
STRINGi7955.ENSDARP00000069236.

Structurei

3D structure databases

SMRiQ9DEA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 175RuntInterPro annotationAdd BLAST129

Phylogenomic databases

eggNOGiKOG3982. Eukaryota.
ENOG4111J4Y. LUCA.
GeneTreeiENSGT00390000016964.
HOVERGENiHBG060268.
KOiK09279.
TreeFamiTF321496.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.770.10. 1 hit.
InterProiView protein in InterPro
IPR000040. AML1_Runt.
IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR013524. Runt_dom.
IPR027384. Runx_central_dom.
IPR013711. RunxI_C_dom.
IPR016554. TF_Runt-rel_RUNX.
PANTHERiPTHR11950. PTHR11950. 1 hit.
PfamiView protein in Pfam
PF00853. Runt. 1 hit.
PF08504. RunxI. 1 hit.
PIRSFiPIRSF009374. TF_Runt-rel_RUNX. 1 hit.
PRINTSiPR00967. ONCOGENEAML1.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS51062. RUNT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DEA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIPVDPSTS RRFTPPSASF PCAKVTESQS MSAPGPLRSG RPVESRSVVD
60 70 80 90 100
VLADHAGELV RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGDVPDGTLV
110 120 130 140 150
TVMAGNDENY SAELRNASAV MKNQVARFND LRFVGRSGRG KSFTLTITVF
160 170 180 190 200
TGPPQVATYH RAIKVTVDGP REPRRHRVKP DDPHKQFSDR LSDIERFQRA
210 220 230 240 250
SLRMNPGNGT TRPHQTHYSP SSTTQIPGLW PDQIDPPTLK TCKVEDDLRW
260 270 280 290 300
TSTDLFQQRT SFPSLSPLTA PRFSDSHMHY PSHFTYSANP SSTGIGGLSV
310 320 330 340 350
AGMPTSSRYH TYLPPPYPGN QNQNSHFQTN SSPYHLYYGT GSGSYQFSMI
360 370 380 390 400
PTGGSGSGGD RSPTRMLTSC TAAGGAAGNT GNNNLINANL GNQSDGVDAD
410 420
GSHSNSPTAM SASTRIDESV WRPY
Length:424
Mass (Da):46,014
Last modified:March 1, 2001 - v1
Checksum:iBE3C03723555AA8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01078998 Genomic DNA. No translation available.
CABZ01083958 Genomic DNA. No translation available.
CABZ01083959 Genomic DNA. No translation available.
CABZ01083960 Genomic DNA. No translation available.
CT025744 Genomic DNA. No translation available.
AF104037 mRNA. Translation: AAG43183.1.
BC163552 mRNA. Translation: AAI63552.1.
BC163560 mRNA. Translation: AAI63560.1.
AF510734 mRNA. Translation: AAO85550.1.
RefSeqiNP_571679.2. NM_131604.2.
UniGeneiDr.82593.

Genome annotation databases

EnsembliENSDART00000161144; ENSDARP00000136974; ENSDARG00000052826.
GeneIDi58127.
KEGGidre:58127.

Similar proteinsi

Entry informationi

Entry nameiQ9DEA0_DANRE
AccessioniPrimary (citable) accession number: Q9DEA0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported