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Protein
Submitted name:

Cytochrome P450 3A

Gene

CYP3A

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 3AImported
Gene namesi
Name:CYP3AImported
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 30HelicalSequence analysisAdd BLAST19
Transmembranei215 – 233HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ9DE99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DE99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFLYFSAE TWTLLVAFIT LLLVYAYWPY GTFKRLGIPG PKPVPFFGTM
60 70 80 90 100
LAYRKGFPIF DEECHKKYGK TWGIYDGRQP VLCITDPATI KAVLVKECYS
110 120 130 140 150
LFTNRRNFHL NGPMYDSVFN AEDDQWKRIR SVLSPSFTSG RLKEMFDIMK
160 170 180 190 200
HHSANLVNSM KKKADKDEPL NLKDHFGPYS MDVVTSTAFS VDIDSLNNPS
210 220 230 240 250
DPFVTNIKKM LKFDFLNPLF LLVAFFPFLG PIMEKMELSF FPASAFDFFY
260 270 280 290 300
SALQKIKSDH KNNKQKSRID FLQLMIDSQK NNQNGLQDKG LSDHEILSQA
310 320 330 340 350
MIFIFAGYET TSSSLTFLAY NLATNPEVMK KLQKEIDATF PNKAPIQYAP
360 370 380 390 400
LLEMEYLDSV VNESLRLYPI AARLERVAKA TVEVNGLVIP KDMVVMVPTW
410 420 430 440 450
PIQRDPELWP EPEKFKPERF SKETKETFDP YTYMPFGAGP RNCIGMRFAL
460 470 480 490 500
VSMKLALVEI LQQYSFSVCK ETEIPFELDI QGLIAPKRPI FLKLVPRSAC
Length:500
Mass (Da):57,382
Last modified:March 1, 2001 - v1
Checksum:iEB0A8479601CE8C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105018 mRNA. Translation: AAG35209.1.
RefSeqiNP_001292334.1. NM_001305405.1.
XP_004085708.2. XM_004085660.2.
UniGeneiOla.18272.

Genome annotation databases

GeneIDi101155406.
101167177.
KEGGiola:101155406.
ola:101167177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105018 mRNA. Translation: AAG35209.1.
RefSeqiNP_001292334.1. NM_001305405.1.
XP_004085708.2. XM_004085660.2.
UniGeneiOla.18272.

3D structure databases

ProteinModelPortaliQ9DE99.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101155406.
101167177.
KEGGiola:101155406.
ola:101167177.

Organism-specific databases

CTDi101155406.

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9DE99_ORYLA
AccessioniPrimary (citable) accession number: Q9DE99
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.