Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin

Gene

cla

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:claImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

  • Cell junctiontight junction SAAS annotation
  • Cell junctiontight junction UniRule annotation
  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Cell membrane SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2722HelicalSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Transmembranei79 – 10224HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14422HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18320HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG000643.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DE12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGLQILG MAMSIIGWVG SIISCALPMW RVTAFIGNNI VVAQIIWEGL
60 70 80 90 100
WMNCIVQSTG QMQCKVYDSM LALAQDLQAA RALTVICILV ALLAMFIGIV
110 120 130 140 150
GAKCTNCIED ENTKAKVSMV SGIVFLVAGI LMLIPVCWSA NSIIRDFYNP
160 170 180 190 200
LVVEAQKREL GAALYIRWAS SALLLLGGSL LCCSCPKKND APYPARYTAP
210
SCPPRSDYTS KNYV
Length:214
Mass (Da):23,152
Last modified:March 1, 2001 - v1
Checksum:i3F0D65E3ADE311E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224712 mRNA. Translation: AAG44257.1.
UniGeneiXl.12099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224712 mRNA. Translation: AAG44257.1.
UniGeneiXl.12099.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000643.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Overexpression of the Xenopus tight-junction protein claudin causes randomization of the left-right body axis."
    Brizuela B.J., Wessely O., De Robertis E.M.
    Dev. Biol. 230:217-229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Dorsal lipImported.

Entry informationi

Entry nameiQ9DE12_XENLA
AccessioniPrimary (citable) accession number: Q9DE12
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.