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Q9DDE3

- ACES_DANRE

UniProt

Q9DDE3 - ACES_DANRE

Protein

Acetylcholinesterase

Gene

ache

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

    Catalytic activityi

    Acetylcholine + H2O = choline + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei225 – 2251Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei352 – 3521Charge relay systemBy similarity
    Active sitei495 – 4951Charge relay systemBy similarity

    GO - Molecular functioni

    1. acetylcholinesterase activity Source: ZFIN
    2. cholinesterase activity Source: RefGenome

    GO - Biological processi

    1. acetylcholine catabolic process Source: ZFIN
    2. cellular response to methanol Source: ZFIN
    3. choline metabolic process Source: RefGenome
    4. myofibril assembly Source: ZFIN
    5. neuromuscular junction development Source: ZFIN
    6. neuron development Source: ZFIN
    7. regulation of synapse structure and activity Source: ZFIN
    8. response to amphetamine Source: ZFIN
    9. response to ethanol Source: ZFIN
    10. synaptic transmission, cholinergic Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Neurotransmitter degradation

    Enzyme and pathway databases

    ReactomeiREACT_174660. Synthesis of PC.

    Protein family/group databases

    MEROPSiS09.979.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholinesterase (EC:3.1.1.7)
    Short name:
    AChE
    Gene namesi
    Name:ache
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 7

    Organism-specific databases

    ZFINiZDB-GENE-010906-1. ache.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. endoplasmic reticulum lumen Source: RefGenome
    3. extracellular space Source: RefGenome
    4. plasma membrane Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 634611AcetylcholinesterasePRO_0000008593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi91 ↔ 118By similarity
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi279 ↔ 290By similarity
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi427 ↔ 580By similarity
    Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi631 – 631InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Gene expression databases

    BgeeiQ9DDE3.

    Interactioni

    Subunit structurei

    Dimers and collagen-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers from dimers.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DDE3.
    SMRiQ9DDE3. Positions 28-592, 595-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2272.
    GeneTreeiENSGT00740000115241.
    HOGENOMiHOG000091866.
    HOVERGENiHBG008839.
    InParanoidiQ9DDE3.
    KOiK01049.
    OMAiWEAFADI.
    OrthoDBiEOG789C9R.
    PhylomeDBiQ9DDE3.
    TreeFamiTF315470.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR014788. AChE_tetra.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF08674. AChE_tetra. 1 hit.
    PF00135. COesterase. 2 hits.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    ProDomiPD415333. AChE_tetra. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DDE3-1 [UniParc]FASTAAdd to Basket

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    MKTSDILLLP TVLLTFLFHN CFAQAEPDLV VATRLGRVQG TRLPVPDRSH    50
    VIAFLGIPYA EPPIGKRRFK RAEPKKPWNN VFEAKEFSNA CYQFVDTSYP 100
    GFPGIEMWNP NRVMSEDCLY LNVWVPPTPR PQNLTVMVWI YGGGFYSGSS 150
    SLDVYDGRYL AYTEKVVVVS MNYRVGAFGF LALNGSSDAP GNVGLYDQRL 200
    ALQWVQENIH FFGGNPKQVT IFGESAGAAS VGMHVLSPDS RPLFTRAILQ 250
    SGVPNTPWAT VTFDEARRRT TKLGKLVGCT WGNDTELIDC LRNKHPQELI 300
    DQEWQVLPWS SLFRFSFVPV VDGVFFPDTP DAMISSGNFK YTQILLGVNQ 350
    DEGSYFLLYG APGFSKDNES LISREDFLES VKMGVPHAND IGLEAVILQY 400
    TDWMDENNGQ KNRDAMDDIV GDQNVICPLQ HFAKSYAQYA ALHAQSSAAA 450
    PGTLGWGNSG PTGYNSGNSH GAVYLYLFDH RASNLAWPEW MGVIHGYEIE 500
    FVFGLPLEKR LNYTAEEEKL SRRIMRYWAN FARTGNPNVN TDGTMDSRRR 550
    WPQFSANEQK HVGLNTEPMK VHKGLRTQFC ALWNRFLPRL LNITDNIDDV 600
    ERQWKVEFHR WSSYMMHWKS QFDHYSKQER CTDL 634
    Length:634
    Mass (Da):71,998
    Last modified:March 1, 2001 - v1
    Checksum:i47F348EA8A7C1E52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251640 Genomic DNA. Translation: CAC19790.1.
    RefSeqiNP_571921.1. NM_131846.1.
    UniGeneiDr.133438.

    Genome annotation databases

    EnsembliENSDART00000052989; ENSDARP00000052988; ENSDARG00000031796.
    GeneIDi114549.
    KEGGidre:114549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251640 Genomic DNA. Translation: CAC19790.1 .
    RefSeqi NP_571921.1. NM_131846.1.
    UniGenei Dr.133438.

    3D structure databases

    ProteinModelPortali Q9DDE3.
    SMRi Q9DDE3. Positions 28-592, 595-628.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000052989 ; ENSDARP00000052988 ; ENSDARG00000031796 .
    GeneIDi 114549.
    KEGGi dre:114549.

    Organism-specific databases

    CTDi 43.
    ZFINi ZDB-GENE-010906-1. ache.

    Phylogenomic databases

    eggNOGi COG2272.
    GeneTreei ENSGT00740000115241.
    HOGENOMi HOG000091866.
    HOVERGENi HBG008839.
    InParanoidi Q9DDE3.
    KOi K01049.
    OMAi WEAFADI.
    OrthoDBi EOG789C9R.
    PhylomeDBi Q9DDE3.
    TreeFami TF315470.

    Enzyme and pathway databases

    Reactomei REACT_174660. Synthesis of PC.

    Miscellaneous databases

    NextBioi 20796951.
    PROi Q9DDE3.

    Gene expression databases

    Bgeei Q9DDE3.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR014788. AChE_tetra.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF08674. AChE_tetra. 1 hit.
    PF00135. COesterase. 2 hits.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    ProDomi PD415333. AChE_tetra. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zebrafish acetylcholinesterase is encoded by a single gene localized on linkage group 7. gene structure and polymorphism; molecular forms and expression pattern during development."
      Bertrand C., Chatonnet A., Takke C., Yan Y., Postlethwait J., Toutant J.-P., Cousin X.
      J. Biol. Chem. 276:464-474(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiACES_DANRE
    AccessioniPrimary (citable) accession number: Q9DDE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    No other isoforms exist. This protein corresponds to the T isoform in other species.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3