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Protein

Neurobeachin

Gene

NBEA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin
Gene namesi
Name:NBEA
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›793›793NeurobeachinPRO_0000051091Add
BLAST

Proteomic databases

PaxDbiQ9DDD5.
PRIDEiQ9DDD5.

Expressioni

Tissue specificityi

Forebrain and cerebellum.1 Publication

Interactioni

Subunit structurei

Interacts with RII subunit of PKA.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027505.

Family & Domainsi

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated

Phylogenomic databases

eggNOGiNOG236271.
InParanoidiQ9DDD5.
PhylomeDBiQ9DDD5.

Sequencei

Sequence statusi: Fragment.

Q9DDD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PKNSEEQKIT EMVYNIFRIL LYHAIKYEWG GWRVWVDTLS IAHSKVTYEA
60 70 80 90 100
HKEYLAKMYE EYQRQEEENI KKGKKGNVST ISGLSSQTTG AKGGMEIREI
110 120 130 140 150
EDLSQSQSPE SETDYPVSTD TRDLLMATKV SDDVLGSAER PGGGVHVEVH
160 170 180 190 200
DLLVDIKAER VEATEVKLDD MDLSPETLVT GENGALVEVE SLLDNVYSAA
210 220 230 240 250
VEKLQNSVHG SVGIIKKNEE KDGGPLITLA DEKDEPSTNS TSFLFDKIPS
260 270 280 290 300
QEEKLLPDLS ISHISIPNVQ DTQMHLGVND DLGLLAHMTG GVDITSTSSI
310 320 330 340 350
IEDKEFKIHT NSVGMSSIFE RELASLFKGL EYAEMTATTP ETEFFCSKTV
360 370 380 390 400
PNVDAGSIIS VTERFVDGKE AGKEIRKIQT TTTTQAVQGR SVTQQDRDLR
410 420 430 440 450
VDLGFRGMPM TEEQRRQFSP GPRTNMFRIP EFKWSPMHQR LLTDLLFALE
460 470 480 490 500
TDVHVWRSHS TKSVMDFVNS NENIIFVHNT IHLISQMVDN IIIACGGILP
510 520 530 540 550
LLSAATSPTG SKTELENIEV TQGMSAETAV TFLSRLMAMV DVLVFASSLN
560 570 580 590 600
FSEIEAEKNM SSGGLMRQCL RLVCCVAVRN CLECRQRQRE RVNKTSLISS
610 620 630 640 650
KAQDALQGVT ASAATKTPLE NVPGNLSPIK DPDRLLQDVD INRLRAVVFR
660 670 680 690 700
DVDDSKQAQF LALAVVYFIS VLMVSKYRDI LEPQRETARS GSQAGRNIRQ
710 720 730 740 750
EINSPTSTET PAVFPENIKD KETPTPVEDI QLESSIPHTD SGIGEEQMPN
760 770 780 790
ILNGTDLETS TGPDAMSELL STLSSEVKKS QESLTESPSE ILK
Length:793
Mass (Da):87,803
Last modified:March 1, 2001 - v1
Checksum:i19F5AC6C49A7F2A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei793 – 7931Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18277 mRNA. Translation: CAC18801.1.
UniGeneiGga.18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18277 mRNA. Translation: CAC18801.1.
UniGeneiGga.18.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027505.

Proteomic databases

PaxDbiQ9DDD5.
PRIDEiQ9DDD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG236271.
InParanoidiQ9DDD5.
PhylomeDBiQ9DDD5.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Neurobeachin: a protein kinase A-anchoring, beige/Chediak-Higashi protein homolog implicated in neuronal membrane traffic."
    Wang X., Herberg F.W., Laue M.M., Wullner C., Hu B., Petrasch-Parwez E., Kilimann M.W.
    J. Neurosci. 20:8551-8565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: BrainImported.

Entry informationi

Entry nameiNBEA_CHICK
AccessioniPrimary (citable) accession number: Q9DDD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.