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Protein

Toll-like receptor 2 type-1

Gene

TLR2-1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-451514. MyD88:TIRAP-dependent cascade initiated on plasma membrane.
R-GGA-517856. TLR2 subfamily cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 2 type-1
Gene namesi
Name:TLR2-1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 597ExtracellularSequence analysisAdd BLAST572
Transmembranei598 – 618HelicalSequence analysisAdd BLAST21
Topological domaini619 – 793CytoplasmicSequence analysisAdd BLAST175

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003471326 – 793Toll-like receptor 2 type-1Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 47By similarity
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi362 ↔ 391By similarity
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi441 ↔ 463By similarity
Glycosylationi451N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated. TLR2-1 is more heavily glycosylated than TLR2-2.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DD78.

Expressioni

Tissue specificityi

Highly expressed in ovary. Detected at lower levels in heart, lung, gizzard and testis.

Interactioni

Subunit structurei

Binds MYD88 (via TIR domain).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015018.

Structurei

3D structure databases

ProteinModelPortaliQ9DD78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 85LRR 1Add BLAST22
Repeati88 – 109LRR 2Add BLAST22
Repeati112 – 133LRR 3Add BLAST22
Repeati136 – 157LRR 4Add BLAST22
Repeati161 – 182LRR 5Add BLAST22
Repeati185 – 206LRR 6Add BLAST22
Repeati370 – 391LRR 7Add BLAST22
Repeati397 – 418LRR 8Add BLAST22
Repeati423 – 444LRR 9Add BLAST22
Repeati446 – 467LRR 10Add BLAST22
Repeati468 – 486LRR 11Add BLAST19
Repeati487 – 508LRR 12Add BLAST22
Repeati509 – 530LRR 13Add BLAST22
Domaini542 – 596LRRCTAdd BLAST55
Domaini648 – 793TIRPROSITE-ProRule annotationAdd BLAST146

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000110611.
HOVERGENiHBG108574.
InParanoidiQ9DD78.
KOiK10159.
PhylomeDBiQ9DD78.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR018247. EF_Hand_1_Ca_BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR017241. Toll-like_receptor.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DD78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNQSKQKPT MKLMWQAWLI YTALAAHLPE EQALRQACLS CDATQSCNCS
60 70 80 90 100
FMGLDFIPPG LTGKITVLNL AHNRIKLIRT HDLQKAVNLR TLLLQSNQIS
110 120 130 140 150
SIDEDSFGSQ GKLELLDLSN NSLAHLSPVW FGPLFSLQHL RIQGNSYSDL
160 170 180 190 200
GESSPFSSLR NLSSLHLGNP QFSIIRQGNF EGIVFLNTLR IDGDNLSQYE
210 220 230 240 250
PGSLKSIRKI NHMIISIRRI DVFSAVIRDL LHSAIWLEVR EIKLDIENEK
260 270 280 290 300
LVQNSTLPLT IQKLTFTGAS FTDKYISQIA VLLKEIRSLR ELEAIDCVLE
310 320 330 340 350
GKGAWDMTEI ARSKQSSIET LSITNMTILD FYLFFDLEGI ETQVGKLKRL
360 370 380 390 400
SIASSKVFMV PCRLARYFSS LLYLDFHDNL LVNNRLGETI CEDAWPSLQT
410 420 430 440 450
LNLSKNSLKS LKQAARYISN LHKLINLDIS ENNFGEIPDM CEWPENLKYL
460 470 480 490 500
NLSSTQIPKL TTCIPSTLEV LDVSANNLQD FGLQLPFLKE LYLTKNHLKT
510 520 530 540 550
LPEATDIPNL VAMSISRNKL NSFSKEEFES FKQMELLDAS ANNFICSCEF
560 570 580 590 600
LSFIHHEAGI AQVLVGWPES YICDSPLTVR GAQVGSVQLS LMECHRSLLV
610 620 630 640 650
SLICTLVFLF ILILVVVGYK YHAVWYMRMT WAWLQAKRKP KRAPTKDICY
660 670 680 690 700
DAFVSYSEND SNWVENIMVQ QLEQACPPFR LCLHKRDFVP GKWIVDNIID
710 720 730 740 750
SIEKSHKTLF VLSEHFVQSE WCKYELDFSH FRLFDENNDV AILILLEPIQ
760 770 780 790
SQAIPKRFCK LRKIMNTKTY LEWPPDEEQQ QMFWENLKAA LKS
Length:793
Mass (Da):90,767
Last modified:March 1, 2001 - v1
Checksum:i2BF659D9305D4562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050005 mRNA. Translation: BAB16843.1.
AB046119 mRNA. Translation: BAB16113.2.
RefSeqiNP_989609.1. NM_204278.1.
UniGeneiGga.98.

Genome annotation databases

GeneIDi374141.
KEGGigga:374141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050005 mRNA. Translation: BAB16843.1.
AB046119 mRNA. Translation: BAB16113.2.
RefSeqiNP_989609.1. NM_204278.1.
UniGeneiGga.98.

3D structure databases

ProteinModelPortaliQ9DD78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015018.

Proteomic databases

PaxDbiQ9DD78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374141.
KEGGigga:374141.

Organism-specific databases

CTDi101792125.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000110611.
HOVERGENiHBG108574.
InParanoidiQ9DD78.
KOiK10159.
PhylomeDBiQ9DD78.
TreeFamiTF351113.

Enzyme and pathway databases

ReactomeiR-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-451514. MyD88:TIRAP-dependent cascade initiated on plasma membrane.
R-GGA-517856. TLR2 subfamily cascade.

Miscellaneous databases

PROiQ9DD78.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR018247. EF_Hand_1_Ca_BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR017241. Toll-like_receptor.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR21_CHICK
AccessioniPrimary (citable) accession number: Q9DD78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.