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Protein

Toll-like receptor 2 type-1

Gene

TLR2-1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-451514. MyD88:TIRAP-dependent cascade initiated on plasma membrane.
R-GGA-517856. TLR2 subfamily cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 2 type-1
Gene namesi
Name:TLR2-1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 597572ExtracellularSequence analysisAdd
BLAST
Transmembranei598 – 61821HelicalSequence analysisAdd
BLAST
Topological domaini619 – 793175CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 793768Toll-like receptor 2 type-1PRO_0000034713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 47By similarity
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi362 ↔ 391By similarity
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 463By similarity
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated. TLR2-1 is more heavily glycosylated than TLR2-2.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DD78.

Expressioni

Tissue specificityi

Highly expressed in ovary. Detected at lower levels in heart, lung, gizzard and testis.

Interactioni

Subunit structurei

Binds MYD88 (via TIR domain).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015018.

Structurei

3D structure databases

ProteinModelPortaliQ9DD78.
SMRiQ9DD78. Positions 648-793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 8522LRR 1Add
BLAST
Repeati88 – 10922LRR 2Add
BLAST
Repeati112 – 13322LRR 3Add
BLAST
Repeati136 – 15722LRR 4Add
BLAST
Repeati161 – 18222LRR 5Add
BLAST
Repeati185 – 20622LRR 6Add
BLAST
Repeati370 – 39122LRR 7Add
BLAST
Repeati397 – 41822LRR 8Add
BLAST
Repeati423 – 44422LRR 9Add
BLAST
Repeati446 – 46722LRR 10Add
BLAST
Repeati468 – 48619LRR 11Add
BLAST
Repeati487 – 50822LRR 12Add
BLAST
Repeati509 – 53022LRR 13Add
BLAST
Domaini542 – 59655LRRCTAdd
BLAST
Domaini648 – 793146TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000110611.
HOVERGENiHBG108574.
InParanoidiQ9DD78.
KOiK10159.
OrthoDBiEOG7SBNN7.
PhylomeDBiQ9DD78.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR018247. EF_Hand_1_Ca_BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR017241. Toll-like_receptor.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DD78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNQSKQKPT MKLMWQAWLI YTALAAHLPE EQALRQACLS CDATQSCNCS
60 70 80 90 100
FMGLDFIPPG LTGKITVLNL AHNRIKLIRT HDLQKAVNLR TLLLQSNQIS
110 120 130 140 150
SIDEDSFGSQ GKLELLDLSN NSLAHLSPVW FGPLFSLQHL RIQGNSYSDL
160 170 180 190 200
GESSPFSSLR NLSSLHLGNP QFSIIRQGNF EGIVFLNTLR IDGDNLSQYE
210 220 230 240 250
PGSLKSIRKI NHMIISIRRI DVFSAVIRDL LHSAIWLEVR EIKLDIENEK
260 270 280 290 300
LVQNSTLPLT IQKLTFTGAS FTDKYISQIA VLLKEIRSLR ELEAIDCVLE
310 320 330 340 350
GKGAWDMTEI ARSKQSSIET LSITNMTILD FYLFFDLEGI ETQVGKLKRL
360 370 380 390 400
SIASSKVFMV PCRLARYFSS LLYLDFHDNL LVNNRLGETI CEDAWPSLQT
410 420 430 440 450
LNLSKNSLKS LKQAARYISN LHKLINLDIS ENNFGEIPDM CEWPENLKYL
460 470 480 490 500
NLSSTQIPKL TTCIPSTLEV LDVSANNLQD FGLQLPFLKE LYLTKNHLKT
510 520 530 540 550
LPEATDIPNL VAMSISRNKL NSFSKEEFES FKQMELLDAS ANNFICSCEF
560 570 580 590 600
LSFIHHEAGI AQVLVGWPES YICDSPLTVR GAQVGSVQLS LMECHRSLLV
610 620 630 640 650
SLICTLVFLF ILILVVVGYK YHAVWYMRMT WAWLQAKRKP KRAPTKDICY
660 670 680 690 700
DAFVSYSEND SNWVENIMVQ QLEQACPPFR LCLHKRDFVP GKWIVDNIID
710 720 730 740 750
SIEKSHKTLF VLSEHFVQSE WCKYELDFSH FRLFDENNDV AILILLEPIQ
760 770 780 790
SQAIPKRFCK LRKIMNTKTY LEWPPDEEQQ QMFWENLKAA LKS
Length:793
Mass (Da):90,767
Last modified:March 1, 2001 - v1
Checksum:i2BF659D9305D4562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050005 mRNA. Translation: BAB16843.1.
AB046119 mRNA. Translation: BAB16113.2.
RefSeqiNP_989609.1. NM_204278.1.
UniGeneiGga.98.

Genome annotation databases

GeneIDi374141.
KEGGigga:374141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050005 mRNA. Translation: BAB16843.1.
AB046119 mRNA. Translation: BAB16113.2.
RefSeqiNP_989609.1. NM_204278.1.
UniGeneiGga.98.

3D structure databases

ProteinModelPortaliQ9DD78.
SMRiQ9DD78. Positions 648-793.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015018.

Proteomic databases

PaxDbiQ9DD78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374141.
KEGGigga:374141.

Organism-specific databases

CTDi101792125.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000110611.
HOVERGENiHBG108574.
InParanoidiQ9DD78.
KOiK10159.
OrthoDBiEOG7SBNN7.
PhylomeDBiQ9DD78.
TreeFamiTF351113.

Enzyme and pathway databases

ReactomeiR-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-451514. MyD88:TIRAP-dependent cascade initiated on plasma membrane.
R-GGA-517856. TLR2 subfamily cascade.

Miscellaneous databases

PROiQ9DD78.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR018247. EF_Hand_1_Ca_BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR017241. Toll-like_receptor.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional characterization of chicken Toll-like receptors. A single chicken Toll covers multiple molecular patterns."
    Fukui A., Inoue N., Matsumoto M., Nomura M., Yamada K., Matsuda Y., Toyoshima K., Seya T.
    J. Biol. Chem. 276:47143-47149(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Molecular cloning and expression analysis of the chick Toll-like receptor 2 in embryonic ventricular myocytes."
    Takahashi T.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTLR21_CHICK
AccessioniPrimary (citable) accession number: Q9DD78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.