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Q9DD33

- PSB9_SALSA

UniProt

Q9DD33 - PSB9_SALSA

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Protein

Proteasome subunit beta type-9

Gene

psmb9-a

more
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 192Cleavage; by autocatalysisBy similarity
Active sitei19 – 191NucleophileBy similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
  2. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Keywords - Biological processi

Immunity

Protein family/group databases

MEROPSiT01.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-9 (EC:3.4.25.1)
Alternative name(s):
Low molecular mass protein 2
Gene namesi
Name:psmb9-a
Synonyms:lmp2-a
AND
Name:psmb9-b
Synonyms:lmp2-b
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 1818Removed in mature formBy similarityPRO_0000026637Add
BLAST
Chaini19 – 217199Proteasome subunit beta type-9PRO_0000026638Add
BLAST

Post-translational modificationi

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity (By similarity).By similarity

Keywords - PTMi

Zymogen

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9DD33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000123.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DD33-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEESSEPGW LSEEVKTGTT IIAIEFDGGV VLGSDSRVSA GETVVNRVMN
60 70 80 90 100
KLSLLHDKIY CALSGSAADA QTIAEMVNYQ LDVHSIEVGE DPQVRSAATL
110 120 130 140 150
VKNISYKYKE ELSAHLIVAG WDKRGGGQVY VTLNGLLSRQ PFAVGGSGSA
160 170 180 190 200
YVYGFVDAEY RKAMSKEDCQ QFVVNTLSLA MSRDGSSGGV AYLVTIDEKG
210
AEEKCILGNE LPTFYDQ
Length:217
Mass (Da):23,392
Last modified:March 1, 2001 - v1
Checksum:iE3543052F7AEA800
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF184932 mRNA. Translation: AAG43434.1.
AF184933 mRNA. Translation: AAG43435.1.
AF184934 mRNA. Translation: AAG43436.1.
AF184935 mRNA. Translation: AAG43437.1.
AF184936 mRNA. Translation: AAG43438.1.
EF210363 Genomic DNA. Translation: ABQ01991.1.
EF427379 Genomic DNA. Translation: ABQ59649.1.
EF427384 Genomic DNA. Translation: ABQ59682.1.
RefSeqiNP_001117174.1. NM_001123702.2.
NP_001117186.1. NM_001123714.1.
UniGeneiSsa.167.
Ssa.168.

Genome annotation databases

GeneIDi100136936.
100137045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF184932 mRNA. Translation: AAG43434.1 .
AF184933 mRNA. Translation: AAG43435.1 .
AF184934 mRNA. Translation: AAG43436.1 .
AF184935 mRNA. Translation: AAG43437.1 .
AF184936 mRNA. Translation: AAG43438.1 .
EF210363 Genomic DNA. Translation: ABQ01991.1 .
EF427379 Genomic DNA. Translation: ABQ59649.1 .
EF427384 Genomic DNA. Translation: ABQ59682.1 .
RefSeqi NP_001117174.1. NM_001123702.2.
NP_001117186.1. NM_001123714.1.
UniGenei Ssa.167.
Ssa.168.

3D structure databases

ProteinModelPortali Q9DD33.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136936.
100137045.

Organism-specific databases

CTDi 100136936.
100137045.

Phylogenomic databases

HOVERGENi HBG000123.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proteasome genes in Atlantic salmon."
    Grimholt U.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar)."
    Lukacs M.F., Harstad H., Grimholt U., Beetz-Sargent M., Cooper G.A., Reid L., Bakke H.G., Phillips R.B., Miller K.M., Davidson W.S., Koop B.F.
    BMC Genomics 8:251-251(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPSB9_SALSA
AccessioniPrimary (citable) accession number: Q9DD33
Secondary accession number(s): A7KE02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3