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Q9DD33

- PSB9_SALSA

UniProt

Q9DD33 - PSB9_SALSA

Protein

Proteasome subunit beta type-9

Gene

psmb9-a

more
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei18 – 192Cleavage; by autocatalysisBy similarity
    Active sitei19 – 191NucleophileBy similarity

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW
    2. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Keywords - Biological processi

    Immunity

    Protein family/group databases

    MEROPSiT01.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit beta type-9 (EC:3.4.25.1)
    Alternative name(s):
    Low molecular mass protein 2
    Gene namesi
    Name:psmb9-a
    Synonyms:lmp2-a
    AND
    Name:psmb9-b
    Synonyms:lmp2-b
    OrganismiSalmo salar (Atlantic salmon)
    Taxonomic identifieri8030 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

    Subcellular locationi

    Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1818Removed in mature formBy similarityPRO_0000026637Add
    BLAST
    Chaini19 – 217199Proteasome subunit beta type-9PRO_0000026638Add
    BLAST

    Post-translational modificationi

    Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity By similarity.By similarity

    Keywords - PTMi

    Zymogen

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DD33.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1B family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG000123.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000243. Pept_T1A_subB.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    PRINTSiPR00141. PROTEASOME.
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DD33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEESSEPGW LSEEVKTGTT IIAIEFDGGV VLGSDSRVSA GETVVNRVMN    50
    KLSLLHDKIY CALSGSAADA QTIAEMVNYQ LDVHSIEVGE DPQVRSAATL 100
    VKNISYKYKE ELSAHLIVAG WDKRGGGQVY VTLNGLLSRQ PFAVGGSGSA 150
    YVYGFVDAEY RKAMSKEDCQ QFVVNTLSLA MSRDGSSGGV AYLVTIDEKG 200
    AEEKCILGNE LPTFYDQ 217
    Length:217
    Mass (Da):23,392
    Last modified:March 1, 2001 - v1
    Checksum:iE3543052F7AEA800
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184932 mRNA. Translation: AAG43434.1.
    AF184933 mRNA. Translation: AAG43435.1.
    AF184934 mRNA. Translation: AAG43436.1.
    AF184935 mRNA. Translation: AAG43437.1.
    AF184936 mRNA. Translation: AAG43438.1.
    EF210363 Genomic DNA. Translation: ABQ01991.1.
    EF427379 Genomic DNA. Translation: ABQ59649.1.
    EF427384 Genomic DNA. Translation: ABQ59682.1.
    RefSeqiNP_001117174.1. NM_001123702.2.
    NP_001117186.1. NM_001123714.1.
    UniGeneiSsa.167.
    Ssa.168.

    Genome annotation databases

    GeneIDi100136936.
    100137045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184932 mRNA. Translation: AAG43434.1 .
    AF184933 mRNA. Translation: AAG43435.1 .
    AF184934 mRNA. Translation: AAG43436.1 .
    AF184935 mRNA. Translation: AAG43437.1 .
    AF184936 mRNA. Translation: AAG43438.1 .
    EF210363 Genomic DNA. Translation: ABQ01991.1 .
    EF427379 Genomic DNA. Translation: ABQ59649.1 .
    EF427384 Genomic DNA. Translation: ABQ59682.1 .
    RefSeqi NP_001117174.1. NM_001123702.2.
    NP_001117186.1. NM_001123714.1.
    UniGenei Ssa.167.
    Ssa.168.

    3D structure databases

    ProteinModelPortali Q9DD33.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi T01.013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100136936.
    100137045.

    Organism-specific databases

    CTDi 100136936.
    100137045.

    Phylogenomic databases

    HOVERGENi HBG000123.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000243. Pept_T1A_subB.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    PRINTSi PR00141. PROTEASOME.
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteasome genes in Atlantic salmon."
      Grimholt U.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar)."
      Lukacs M.F., Harstad H., Grimholt U., Beetz-Sargent M., Cooper G.A., Reid L., Bakke H.G., Phillips R.B., Miller K.M., Davidson W.S., Koop B.F.
      BMC Genomics 8:251-251(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPSB9_SALSA
    AccessioniPrimary (citable) accession number: Q9DD33
    Secondary accession number(s): A7KE02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3