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Protein

Ras association domain-containing protein 7

Gene

Rassf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 7
Gene namesi
Name:Rassf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914235. Rassf7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Ras association domain-containing protein 7PRO_0000097174Add
BLAST

Post-translational modificationi

Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9DD19.
PaxDbiQ9DD19.
PRIDEiQ9DD19.

Expressioni

Gene expression databases

BgeeiQ9DD19.
ExpressionAtlasiQ9DD19. baseline and differential.
GenevisibleiQ9DD19. MM.

Interactioni

Subunit structurei

Interacts with MAP2K7 and GTP-bound NRAS.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038444.

Structurei

3D structure databases

ProteinModelPortaliQ9DD19.
SMRiQ9DD19. Positions 7-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8984Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili180 – 20829Sequence analysisAdd
BLAST
Coiled coili242 – 30160Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 15420Pro-richAdd
BLAST
Compositional biasi309 – 32820Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1574. Eukaryota.
ENOG410XPWB. LUCA.
GeneTreeiENSGT00530000063648.
HOGENOMiHOG000013031.
HOVERGENiHBG050971.
InParanoidiQ9DD19.
KOiK09855.
OMAiERCPIRA.
OrthoDBiEOG70GMG6.
PhylomeDBiQ9DD19.
TreeFamiTF318385.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DD19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLELVAMEL KVWVDGIQRV VCGVSEQTTC QEVVIALAQA IGQTGRFVLV
60 70 80 90 100
QRLREKERQL LPQECPVGAQ ATCGQFANDV QFVLRRTGPS LSGRPSSDNC
110 120 130 140 150
PPPERCPVRA SLPPKPSAIP GREPRKALTF NLRCPKLVPS PSIPEPAALV
160 170 180 190 200
GPIPDGFADL QDLELRIQRN TEELGHEAFW EQELQREQAR EREGQARLQA
210 220 230 240 250
LSAATAEHAA RLEALDAQAC ALEAELRLAA EAPGPPSATA SAAERLRQDL
260 270 280 290 300
ATQERHSLEM QGTLALVSQA LEAAEHALQA QAQELEELNR ELRQCNLQQF
310 320 330 340 350
IQQTGAALPP PPPQLDRTIP STQDLLSPNR GELQGVPQSH ILVSSLSPEV

PPMRQSSWR
Length:359
Mass (Da):39,247
Last modified:September 26, 2001 - v2
Checksum:i39EF0BCA1D8500F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531L → P in BAB21960 (PubMed:16141072).Curated
Sequence conflicti350 – 3501V → F (PubMed:16141072).Curated
Sequence conflicti353 – 3597Missing (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002243 mRNA. Translation: BAB21960.1.
BC011131 mRNA. Translation: AAH11131.1.
CCDSiCCDS40182.1.
RefSeqiNP_080162.3. NM_025886.3.
XP_006536289.1. XM_006536226.2.
XP_006536290.1. XM_006536227.2.
XP_006536291.1. XM_006536228.2.
UniGeneiMm.21202.

Genome annotation databases

EnsembliENSMUST00000046890; ENSMUSP00000038444; ENSMUSG00000038618.
GeneIDi66985.
KEGGimmu:66985.
UCSCiuc009kka.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002243 mRNA. Translation: BAB21960.1.
BC011131 mRNA. Translation: AAH11131.1.
CCDSiCCDS40182.1.
RefSeqiNP_080162.3. NM_025886.3.
XP_006536289.1. XM_006536226.2.
XP_006536290.1. XM_006536227.2.
XP_006536291.1. XM_006536228.2.
UniGeneiMm.21202.

3D structure databases

ProteinModelPortaliQ9DD19.
SMRiQ9DD19. Positions 7-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038444.

Proteomic databases

MaxQBiQ9DD19.
PaxDbiQ9DD19.
PRIDEiQ9DD19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046890; ENSMUSP00000038444; ENSMUSG00000038618.
GeneIDi66985.
KEGGimmu:66985.
UCSCiuc009kka.1. mouse.

Organism-specific databases

CTDi8045.
MGIiMGI:1914235. Rassf7.

Phylogenomic databases

eggNOGiKOG1574. Eukaryota.
ENOG410XPWB. LUCA.
GeneTreeiENSGT00530000063648.
HOGENOMiHOG000013031.
HOVERGENiHBG050971.
InParanoidiQ9DD19.
KOiK09855.
OMAiERCPIRA.
OrthoDBiEOG70GMG6.
PhylomeDBiQ9DD19.
TreeFamiTF318385.

Miscellaneous databases

NextBioi323220.
PROiQ9DD19.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DD19.
ExpressionAtlasiQ9DD19. baseline and differential.
GenevisibleiQ9DD19. MM.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiRASF7_MOUSE
AccessioniPrimary (citable) accession number: Q9DD19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: November 11, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.