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Q9DD05

- Q9DD05_MOUSE

UniProt

Q9DD05 - Q9DD05_MOUSE

Protein

Delta-aminolevulinic acid dehydratase

Gene

Alad

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi122 – 1221Zinc 1; catalyticUniRule annotation
    Metal bindingi124 – 1241Zinc 1; catalyticUniRule annotation
    Metal bindingi131 – 1311Zinc 2UniRule annotation
    Metal bindingi132 – 1321Zinc 1; catalyticUniRule annotation
    Active sitei199 – 1991Schiff-base intermediate with substrateUniRule annotation
    Binding sitei209 – 2091Substrate 1
    Binding sitei221 – 2211Substrate 1
    Metal bindingi223 – 2231Zinc 2UniRule annotation
    Active sitei252 – 2521Schiff-base intermediate with substrateUniRule annotation
    Binding sitei279 – 2791Substrate 2
    Binding sitei318 – 3181Substrate 2UniRule annotation

    GO - Molecular functioni

    1. identical protein binding Source: MGI
    2. metal ion binding Source: InterPro
    3. porphobilinogen synthase activity Source: MGI

    GO - Biological processi

    1. cellular response to interleukin-4 Source: MGI
    2. heme biosynthetic process Source: MGI

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
    Gene namesi
    Name:AladImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96853. Alad.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9DD05.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9DD05.

    Interactioni

    Subunit structurei

    Homooctamer.UniRule annotation
    Homooctamer By similarity.

    Protein-protein interaction databases

    MINTiMINT-218920.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DD05.
    SMRiQ9DD05. Positions 5-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG001222.
    InParanoidiQ9DD05.
    KOiK01698.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DD05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHHQSVLHSG YFHPLLRSWQ TAASTVSASN LIYPIFVTDV PDDVQPIASL    50
    PGVARYGVNQ LEEMLRPLVE AGLRCVLIFG VPSRVPKDEQ GSAADSEDSP 100
    TIEAVRLLRK TFPSLLVACD VCLCPYTSHG HCGLLSENGA FLSEESRQRL 150
    AEVALAYAKA GCQVVAPSDM MDGRVEAIKA ALLKHGLGNR VSVMSYSAKF 200
    ASCFYGPFRD AAQSSPAFGD RRCYQLPPGA RGLALRAVAR DIQEGADMLM 250
    VKPGLPYLDM VREVKDKHPE LPLAVYQVSG EFAMLWHGAQ AGAFDLRTAV 300
    LETMTAFRRA GADIIITYFA PQLLKWLKEE 330
    Length:330
    Mass (Da):36,040
    Last modified:June 1, 2001 - v1
    Checksum:iC66535A363CB2B81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002300 mRNA. Translation: BAB21998.1.
    RefSeqiNP_001263375.1. NM_001276446.1.
    UniGeneiMm.6988.

    Genome annotation databases

    GeneIDi17025.
    KEGGimmu:17025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002300 mRNA. Translation: BAB21998.1 .
    RefSeqi NP_001263375.1. NM_001276446.1.
    UniGenei Mm.6988.

    3D structure databases

    ProteinModelPortali Q9DD05.
    SMRi Q9DD05. Positions 5-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-218920.

    Proteomic databases

    PRIDEi Q9DD05.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17025.
    KEGGi mmu:17025.

    Organism-specific databases

    CTDi 210.
    MGIi MGI:96853. Alad.

    Phylogenomic databases

    HOVERGENi HBG001222.
    InParanoidi Q9DD05.
    KOi K01698.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9DD05.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ9DD05_MOUSE
    AccessioniPrimary (citable) accession number: Q9DD05
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)