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Q9DD05

- Q9DD05_MOUSE

UniProt

Q9DD05 - Q9DD05_MOUSE

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Protein

Delta-aminolevulinic acid dehydratase

Gene

Alad

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221Zinc 1; catalyticUniRule annotation
Metal bindingi124 – 1241Zinc 1; catalyticUniRule annotation
Metal bindingi131 – 1311Zinc 2UniRule annotation
Metal bindingi132 – 1321Zinc 1; catalyticUniRule annotation
Active sitei199 – 1991Schiff-base intermediate with substrateUniRule annotation
Metal bindingi223 – 2231Zinc 2UniRule annotation
Active sitei252 – 2521Schiff-base intermediate with substrateUniRule annotation
Binding sitei318 – 3181Substrate 2UniRule annotation

GO - Molecular functioni

  1. identical protein binding Source: MGI
  2. metal ion binding Source: InterPro
  3. porphobilinogen synthase activity Source: MGI

GO - Biological processi

  1. cellular response to interleukin-4 Source: MGI
  2. heme biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
Gene namesi
Name:AladImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96853. Alad.

PTM / Processingi

Proteomic databases

PRIDEiQ9DD05.

Expressioni

Gene expression databases

GenevestigatoriQ9DD05.

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Protein-protein interaction databases

MINTiMINT-218920.

Structurei

3D structure databases

ProteinModelPortaliQ9DD05.
SMRiQ9DD05. Positions 5-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001222.
KOiK01698.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DD05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHHQSVLHSG YFHPLLRSWQ TAASTVSASN LIYPIFVTDV PDDVQPIASL
60 70 80 90 100
PGVARYGVNQ LEEMLRPLVE AGLRCVLIFG VPSRVPKDEQ GSAADSEDSP
110 120 130 140 150
TIEAVRLLRK TFPSLLVACD VCLCPYTSHG HCGLLSENGA FLSEESRQRL
160 170 180 190 200
AEVALAYAKA GCQVVAPSDM MDGRVEAIKA ALLKHGLGNR VSVMSYSAKF
210 220 230 240 250
ASCFYGPFRD AAQSSPAFGD RRCYQLPPGA RGLALRAVAR DIQEGADMLM
260 270 280 290 300
VKPGLPYLDM VREVKDKHPE LPLAVYQVSG EFAMLWHGAQ AGAFDLRTAV
310 320 330
LETMTAFRRA GADIIITYFA PQLLKWLKEE
Length:330
Mass (Da):36,040
Last modified:June 1, 2001 - v1
Checksum:iC66535A363CB2B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002300 mRNA. Translation: BAB21998.1.
RefSeqiNP_001263375.1. NM_001276446.1.
UniGeneiMm.6988.

Genome annotation databases

GeneIDi17025.
KEGGimmu:17025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002300 mRNA. Translation: BAB21998.1 .
RefSeqi NP_001263375.1. NM_001276446.1.
UniGenei Mm.6988.

3D structure databases

ProteinModelPortali Q9DD05.
SMRi Q9DD05. Positions 5-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-218920.

Proteomic databases

PRIDEi Q9DD05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 17025.
KEGGi mmu:17025.

Organism-specific databases

CTDi 210.
MGIi MGI:96853. Alad.

Phylogenomic databases

HOVERGENi HBG001222.
KOi K01698.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q9DD05.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ9DD05_MOUSE
AccessioniPrimary (citable) accession number: Q9DD05
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)