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Protein

Delta-aminolevulinic acid dehydratase

Gene

Alad

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi122Zinc 1; catalyticUniRule annotation1
Metal bindingi124Zinc 1; catalyticUniRule annotation1
Metal bindingi131Zinc 2UniRule annotation1
Metal bindingi132Zinc 1; catalyticUniRule annotation1
Active sitei199Schiff-base intermediate with substrateUniRule annotation1
Binding sitei209Substrate 1UniRule annotation1
Binding sitei221Substrate 1UniRule annotation1
Metal bindingi223Zinc 2UniRule annotation1
Active sitei252Schiff-base intermediate with substrateUniRule annotation1
Binding sitei279Substrate 2UniRule annotation1
Binding sitei318Substrate 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processPorphyrin biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
Gene namesi
Name:AladImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96853. Alad.

PTM / Processingi

Proteomic databases

PaxDbiQ9DD05.

Interactioni

Subunit structurei

Homooctamer.UniRule annotation

Protein-protein interaction databases

MINTiMINT-218920.

Structurei

3D structure databases

ProteinModelPortaliQ9DD05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2794. Eukaryota.
COG0113. LUCA.
HOVERGENiHBG001222.
KOiK01698.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR001731. ALAD.
IPR030656. ALAD_AS.
IPR013785. Aldolase_TIM.
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiView protein in Pfam
PF00490. ALAD. 1 hit.
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiView protein in SMART
SM01004. ALAD. 1 hit.
PROSITEiView protein in PROSITE
PS00169. D_ALA_DEHYDRATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DD05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHQSVLHSG YFHPLLRSWQ TAASTVSASN LIYPIFVTDV PDDVQPIASL
60 70 80 90 100
PGVARYGVNQ LEEMLRPLVE AGLRCVLIFG VPSRVPKDEQ GSAADSEDSP
110 120 130 140 150
TIEAVRLLRK TFPSLLVACD VCLCPYTSHG HCGLLSENGA FLSEESRQRL
160 170 180 190 200
AEVALAYAKA GCQVVAPSDM MDGRVEAIKA ALLKHGLGNR VSVMSYSAKF
210 220 230 240 250
ASCFYGPFRD AAQSSPAFGD RRCYQLPPGA RGLALRAVAR DIQEGADMLM
260 270 280 290 300
VKPGLPYLDM VREVKDKHPE LPLAVYQVSG EFAMLWHGAQ AGAFDLRTAV
310 320 330
LETMTAFRRA GADIIITYFA PQLLKWLKEE
Length:330
Mass (Da):36,040
Last modified:June 1, 2001 - v1
Checksum:iC66535A363CB2B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002300 mRNA. Translation: BAB21998.1.
RefSeqiNP_001263375.1. NM_001276446.1.
UniGeneiMm.6988.

Genome annotation databases

GeneIDi17025.
KEGGimmu:17025.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9DD05_MOUSE
AccessioniPrimary (citable) accession number: Q9DD05
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)