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Protein

MICOS complex subunit Mic26

Gene

Apoo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit Mic26
Alternative name(s):
Apolipoprotein O
MICOS complex subunit Mic23
Protein FAM121B
Gene namesi
Name:Apoo
Synonyms:Fam121b, Mic23, Mic26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 13, Chromosome X

Organism-specific databases

MGIiMGI:1915566. Apoo.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 198175MICOS complex subunit Mic26PRO_0000254647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9DCZ4.
MaxQBiQ9DCZ4.
PaxDbiQ9DCZ4.
PeptideAtlasiQ9DCZ4.
PRIDEiQ9DCZ4.

PTM databases

iPTMnetiQ9DCZ4.
PhosphoSiteiQ9DCZ4.
SwissPalmiQ9DCZ4.

Expressioni

Gene expression databases

BgeeiQ9DCZ4.
CleanExiMM_APOO.
GenevisibleiQ9DCZ4. MM.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60. Interacts with MINOS1/MIC10 and APOOL/MIC27.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109530.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4798. Eukaryota.
ENOG4112AZQ. LUCA.
GeneTreeiENSGT00530000063666.
HOGENOMiHOG000034011.
HOVERGENiHBG059567.
InParanoidiQ9DCZ4.
OMAiCEPYTNW.
OrthoDBiEOG7CG70V.
PhylomeDBiQ9DCZ4.
TreeFamiTF315313.

Family and domain databases

InterProiIPR019166. MIC26/MIC27.
IPR033182. MIC26/MIC27_animal.
[Graphical view]
PANTHERiPTHR14564. PTHR14564. 1 hit.
PfamiPF09769. ApoO. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DCZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKVIQRSVG PASLSLLTFR VYAAPKKDSP HKSYMKIDEL SLYSVPEGQS
60 70 80 90 100
KYVEEPRTQL EENISQLRHH CEPYTSFCQE IYSHTKPKVD HFVQWGVDNY
110 120 130 140 150
NYLQNAPPGF FPRLGVIGFA GFVGLLFARG SKIKKLVYPP FFMGLGASVY
160 170 180 190
YPQQAITIAQ ITGEKLYDWG LRGYIVIEDL WKQNFQKPGN VKNSPGNK
Length:198
Mass (Da):22,604
Last modified:July 22, 2015 - v2
Checksum:i6BB8364AF7DC6A3E
GO
Isoform 2 (identifier: Q9DCZ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:164
Mass (Da):18,798
Checksum:i07E1BD898151EB85
GO
Isoform 3 (identifier: Q9DCZ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MFK → MPFWGCGEDEARSGRCR

Show »
Length:212
Mass (Da):24,137
Checksum:i6DA22AC79F55D787
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3434Missing in isoform 2. VSP_057812Add
BLAST
Alternative sequencei1 – 33MFK → MPFWGCGEDEARSGRCR in isoform 3. VSP_057813

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002320 mRNA. Translation: BAB22011.1.
AK003831 mRNA. Translation: BAB23025.1.
AC154603 Genomic DNA. No translation available.
AL627302 Genomic DNA. No translation available.
CT009733 Genomic DNA. No translation available.
CH466637 Genomic DNA. Translation: EDL29756.1.
BC107209 mRNA. Translation: AAI07210.1.
BC016557 mRNA. Translation: AAH16557.1.
CCDSiCCDS53136.1. [Q9DCZ4-1]
CCDS57769.1. [Q9DCZ4-3]
CCDS57770.1. [Q9DCZ4-2]
RefSeqiNP_001186266.1. NM_001199337.1. [Q9DCZ4-3]
NP_001186267.1. NM_001199338.1. [Q9DCZ4-2]
NP_001186268.1. NM_001199339.1. [Q9DCZ4-2]
NP_080949.2. NM_026673.4. [Q9DCZ4-1]
UniGeneiMm.379156.

Genome annotation databases

EnsembliENSMUST00000061241; ENSMUSP00000132704; ENSMUSG00000049233. [Q9DCZ4-1]
ENSMUST00000113895; ENSMUSP00000109528; ENSMUSG00000079508. [Q9DCZ4-2]
ENSMUST00000113896; ENSMUSP00000109529; ENSMUSG00000079508. [Q9DCZ4-2]
ENSMUST00000113897; ENSMUSP00000109530; ENSMUSG00000079508. [Q9DCZ4-3]
ENSMUST00000113898; ENSMUSP00000109531; ENSMUSG00000079508. [Q9DCZ4-1]
GeneIDi68316.
KEGGimmu:68316.
UCSCiuc009ttl.2. mouse. [Q9DCZ4-1]
uc012hmd.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002320 mRNA. Translation: BAB22011.1.
AK003831 mRNA. Translation: BAB23025.1.
AC154603 Genomic DNA. No translation available.
AL627302 Genomic DNA. No translation available.
CT009733 Genomic DNA. No translation available.
CH466637 Genomic DNA. Translation: EDL29756.1.
BC107209 mRNA. Translation: AAI07210.1.
BC016557 mRNA. Translation: AAH16557.1.
CCDSiCCDS53136.1. [Q9DCZ4-1]
CCDS57769.1. [Q9DCZ4-3]
CCDS57770.1. [Q9DCZ4-2]
RefSeqiNP_001186266.1. NM_001199337.1. [Q9DCZ4-3]
NP_001186267.1. NM_001199338.1. [Q9DCZ4-2]
NP_001186268.1. NM_001199339.1. [Q9DCZ4-2]
NP_080949.2. NM_026673.4. [Q9DCZ4-1]
UniGeneiMm.379156.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109530.

PTM databases

iPTMnetiQ9DCZ4.
PhosphoSiteiQ9DCZ4.
SwissPalmiQ9DCZ4.

Proteomic databases

EPDiQ9DCZ4.
MaxQBiQ9DCZ4.
PaxDbiQ9DCZ4.
PeptideAtlasiQ9DCZ4.
PRIDEiQ9DCZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061241; ENSMUSP00000132704; ENSMUSG00000049233. [Q9DCZ4-1]
ENSMUST00000113895; ENSMUSP00000109528; ENSMUSG00000079508. [Q9DCZ4-2]
ENSMUST00000113896; ENSMUSP00000109529; ENSMUSG00000079508. [Q9DCZ4-2]
ENSMUST00000113897; ENSMUSP00000109530; ENSMUSG00000079508. [Q9DCZ4-3]
ENSMUST00000113898; ENSMUSP00000109531; ENSMUSG00000079508. [Q9DCZ4-1]
GeneIDi68316.
KEGGimmu:68316.
UCSCiuc009ttl.2. mouse. [Q9DCZ4-1]
uc012hmd.1. mouse.

Organism-specific databases

CTDi79135.
MGIiMGI:1915566. Apoo.

Phylogenomic databases

eggNOGiKOG4798. Eukaryota.
ENOG4112AZQ. LUCA.
GeneTreeiENSGT00530000063666.
HOGENOMiHOG000034011.
HOVERGENiHBG059567.
InParanoidiQ9DCZ4.
OMAiCEPYTNW.
OrthoDBiEOG7CG70V.
PhylomeDBiQ9DCZ4.
TreeFamiTF315313.

Miscellaneous databases

PROiQ9DCZ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCZ4.
CleanExiMM_APOO.
GenevisibleiQ9DCZ4. MM.

Family and domain databases

InterProiIPR019166. MIC26/MIC27.
IPR033182. MIC26/MIC27_animal.
[Graphical view]
PANTHERiPTHR14564. PTHR14564. 1 hit.
PfamiPF09769. ApoO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary cancer.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMIC26_MOUSE
AccessioniPrimary (citable) accession number: Q9DCZ4
Secondary accession number(s): B1ASQ2, B1ASQ3, Q9D186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 22, 2015
Last modified: July 6, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.