Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GMP reductase 1

Gene

Gmpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1
Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, NADP, Potassium

Enzyme and pathway databases

ReactomeiR-MMU-74217. Purine salvage.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductase 1UniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPR 1UniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase 1UniRule annotation
Short name:
Guanosine monophosphate reductase 1UniRule annotation
Gene namesi
Name:Gmpr
Synonyms:Gmpr1UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913605. Gmpr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937241 – 345GMP reductase 1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DCZ1.
PaxDbiQ9DCZ1.
PeptideAtlasiQ9DCZ1.
PRIDEiQ9DCZ1.

PTM databases

iPTMnetiQ9DCZ1.
PhosphoSitePlusiQ9DCZ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000253.
CleanExiMM_GMPR.
ExpressionAtlasiQ9DCZ1. baseline and differential.
GenevisibleiQ9DCZ1. MM.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000260.

Structurei

3D structure databases

ProteinModelPortaliQ9DCZ1.
SMRiQ9DCZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221GMP bindingUniRule annotation3
Regioni242 – 243GMP bindingUniRule annotation2
Regioni268 – 270GMP bindingUniRule annotation3
Regioni286 – 290GMP bindingUniRule annotation5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2550. Eukaryota.
COG0516. LUCA.
GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165756.
HOVERGENiHBG051744.
InParanoidiQ9DCZ1.
KOiK00364.
OMAiMSQHSLF.
OrthoDBiEOG091G09KQ.
PhylomeDBiQ9DCZ1.
TreeFamiTF300378.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRIDADLKL DFKDVLLRPK RSSLKSRSEV DLERTFTFRN SKQTYSGIPI
60 70 80 90 100
IVANMDTVGT FEMAVVMSQH AMFTAVHKHY SLDDWKCFAE THPECLQHVA
110 120 130 140 150
VSSGSGQNDL ERMSRILEAV PQVKFICLDV ANGYSEHFVE FVKLVRSKFP
160 170 180 190 200
EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE
260 270 280 290 300
CAGEVIERNG QKLKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGD
310 320 330 340
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFG
Length:345
Mass (Da):37,482
Last modified:June 1, 2001 - v1
Checksum:i9A801692C9284D72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002326 mRNA. Translation: BAB22014.1.
AK084508 mRNA. Translation: BAC39203.1.
BC010827 mRNA. Translation: AAH10827.1.
CCDSiCCDS26482.1.
RefSeqiNP_079784.1. NM_025508.5.
UniGeneiMm.290802.

Genome annotation databases

EnsembliENSMUST00000000260; ENSMUSP00000000260; ENSMUSG00000000253.
GeneIDi66355.
KEGGimmu:66355.
UCSCiuc007qha.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002326 mRNA. Translation: BAB22014.1.
AK084508 mRNA. Translation: BAC39203.1.
BC010827 mRNA. Translation: AAH10827.1.
CCDSiCCDS26482.1.
RefSeqiNP_079784.1. NM_025508.5.
UniGeneiMm.290802.

3D structure databases

ProteinModelPortaliQ9DCZ1.
SMRiQ9DCZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000260.

PTM databases

iPTMnetiQ9DCZ1.
PhosphoSitePlusiQ9DCZ1.

Proteomic databases

MaxQBiQ9DCZ1.
PaxDbiQ9DCZ1.
PeptideAtlasiQ9DCZ1.
PRIDEiQ9DCZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000260; ENSMUSP00000000260; ENSMUSG00000000253.
GeneIDi66355.
KEGGimmu:66355.
UCSCiuc007qha.1. mouse.

Organism-specific databases

CTDi2766.
MGIiMGI:1913605. Gmpr.

Phylogenomic databases

eggNOGiKOG2550. Eukaryota.
COG0516. LUCA.
GeneTreeiENSGT00530000062923.
HOGENOMiHOG000165756.
HOVERGENiHBG051744.
InParanoidiQ9DCZ1.
KOiK00364.
OMAiMSQHSLF.
OrthoDBiEOG091G09KQ.
PhylomeDBiQ9DCZ1.
TreeFamiTF300378.

Enzyme and pathway databases

ReactomeiR-MMU-74217. Purine salvage.

Miscellaneous databases

PROiQ9DCZ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000253.
CleanExiMM_GMPR.
ExpressionAtlasiQ9DCZ1. baseline and differential.
GenevisibleiQ9DCZ1. MM.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMPR1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.