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Q9DCX8

- IYD1_MOUSE

UniProt

Q9DCX8 - IYD1_MOUSE

Protein

Iodotyrosine dehalogenase 1

Gene

Iyd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine By similarity.By similarity

    Catalytic activityi

    L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH.

    Cofactori

    FMN.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001Substrate
    Binding sitei157 – 1571Substrate
    Binding sitei178 – 1781Substrate
    Binding sitei275 – 2751FMN

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi96 – 1005FMN
    Nucleotide bindingi123 – 1253FMN
    Nucleotide bindingi232 – 2354FMN

    GO - Molecular functioni

    1. iodide peroxidase activity Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN, NADP

    Enzyme and pathway databases

    ReactomeiREACT_219697. Thyroxine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iodotyrosine dehalogenase 1 (EC:1.22.1.1)
    Short name:
    IYD-1
    Gene namesi
    Name:Iyd
    Synonyms:Dehal1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1917587. Iyd.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 285262Iodotyrosine dehalogenase 1PRO_0000230279Add
    BLAST

    Proteomic databases

    MaxQBiQ9DCX8.
    PaxDbiQ9DCX8.
    PRIDEiQ9DCX8.

    PTM databases

    PhosphoSiteiQ9DCX8.

    Expressioni

    Gene expression databases

    BgeeiQ9DCX8.
    CleanExiMM_IYD.
    GenevestigatoriQ9DCX8.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    IntActiQ9DCX8. 2 interactions.
    MINTiMINT-1857005.
    STRINGi10090.ENSMUSP00000019896.

    Structurei

    Secondary structure

    1
    285
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi69 – 713
    Helixi79 – 9416
    Helixi109 – 11911
    Helixi125 – 1273
    Beta strandi131 – 1366
    Helixi139 – 15113
    Turni159 – 1613
    Helixi163 – 1697
    Helixi170 – 1723
    Helixi180 – 1834
    Beta strandi184 – 19310
    Beta strandi203 – 2053
    Helixi209 – 22618
    Helixi237 – 2393
    Helixi240 – 2467
    Beta strandi253 – 26210
    Beta strandi269 – 2713
    Helixi278 – 2803
    Beta strandi282 – 2843

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3GB5X-ray2.00A34-285[»]
    3GFDX-ray2.45A/B34-285[»]
    3GH8X-ray2.61A/B/C/D/E/F/G/H34-285[»]
    3TNZX-ray2.25A/B34-285[»]
    3TO0X-ray2.66A/B34-285[»]
    ProteinModelPortaliQ9DCX8.
    SMRiQ9DCX8. Positions 66-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9DCX8.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 210187ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 28554CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nitroreductase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0778.
    GeneTreeiENSGT00390000004348.
    HOGENOMiHOG000146731.
    HOVERGENiHBG055004.
    InParanoidiQ9DCX8.
    KOiK17231.
    OMAiRPAHEKL.
    OrthoDBiEOG7HMS24.
    PhylomeDBiQ9DCX8.
    TreeFamiTF313415.

    Family and domain databases

    Gene3Di3.40.109.10. 1 hit.
    InterProiIPR029479. Nitroreductase.
    IPR000415. Nitroreductase-like.
    [Graphical view]
    PfamiPF00881. Nitroreductase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55469. SSF55469. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DCX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLLTPVLVA VVCILVVWVF KNADRNLEKK KEEAQVQPWV DEDLKDSTED    50
    LQVEEDAEEW QEAEESVEHI PFSHTRYPEQ EMRMRSQEFY ELLNKRRSVR 100
    FISSEHVPME VIENVIKAAG TAPSGAHTEP WTFVVVKDPD MKHKIREIIE 150
    EEEEINYMKR MGKRWVTDLK KLRTNWIKEY LDTAPVLILI FKQVHGFAAN 200
    GKKKVHYYNE ISVSIACGLL LAALQNAGLV TVTTTPLNCG PRLRVLLGRP 250
    SHEKLLVLLP VGYPSRDATV PDLKRKALDQ IMVTV 285
    Length:285
    Mass (Da):32,814
    Last modified:June 1, 2001 - v1
    Checksum:i7B7415D6C28B1A58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002363 mRNA. Translation: BAB22041.1.
    BC023358 mRNA. Translation: AAH23358.1.
    CCDSiCCDS56670.1.
    RefSeqiNP_081667.1. NM_027391.3.
    UniGeneiMm.24153.

    Genome annotation databases

    EnsembliENSMUST00000019896; ENSMUSP00000019896; ENSMUSG00000019762.
    GeneIDi70337.
    KEGGimmu:70337.
    UCSCiuc007ehp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002363 mRNA. Translation: BAB22041.1 .
    BC023358 mRNA. Translation: AAH23358.1 .
    CCDSi CCDS56670.1.
    RefSeqi NP_081667.1. NM_027391.3.
    UniGenei Mm.24153.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3GB5 X-ray 2.00 A 34-285 [» ]
    3GFD X-ray 2.45 A/B 34-285 [» ]
    3GH8 X-ray 2.61 A/B/C/D/E/F/G/H 34-285 [» ]
    3TNZ X-ray 2.25 A/B 34-285 [» ]
    3TO0 X-ray 2.66 A/B 34-285 [» ]
    ProteinModelPortali Q9DCX8.
    SMRi Q9DCX8. Positions 66-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DCX8. 2 interactions.
    MINTi MINT-1857005.
    STRINGi 10090.ENSMUSP00000019896.

    PTM databases

    PhosphoSitei Q9DCX8.

    Proteomic databases

    MaxQBi Q9DCX8.
    PaxDbi Q9DCX8.
    PRIDEi Q9DCX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019896 ; ENSMUSP00000019896 ; ENSMUSG00000019762 .
    GeneIDi 70337.
    KEGGi mmu:70337.
    UCSCi uc007ehp.1. mouse.

    Organism-specific databases

    CTDi 389434.
    MGIi MGI:1917587. Iyd.

    Phylogenomic databases

    eggNOGi COG0778.
    GeneTreei ENSGT00390000004348.
    HOGENOMi HOG000146731.
    HOVERGENi HBG055004.
    InParanoidi Q9DCX8.
    KOi K17231.
    OMAi RPAHEKL.
    OrthoDBi EOG7HMS24.
    PhylomeDBi Q9DCX8.
    TreeFami TF313415.

    Enzyme and pathway databases

    Reactomei REACT_219697. Thyroxine biosynthesis.

    Miscellaneous databases

    EvolutionaryTracei Q9DCX8.
    NextBioi 331404.
    PROi Q9DCX8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCX8.
    CleanExi MM_IYD.
    Genevestigatori Q9DCX8.

    Family and domain databases

    Gene3Di 3.40.109.10. 1 hit.
    InterProi IPR029479. Nitroreductase.
    IPR000415. Nitroreductase-like.
    [Graphical view ]
    Pfami PF00881. Nitroreductase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55469. SSF55469. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    3. "Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands."
      Thomas S.R., McTamney P.M., Adler J.M., Laronde-Leblanc N., Rokita S.E.
      J. Biol. Chem. 284:19659-19667(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 34-285 IN COMPLEXES WITH 3,5-DIIODOTYROSINE; 3-IODO-TYROSINE AND FMN, SUBUNIT.

    Entry informationi

    Entry nameiIYD1_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3