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Protein

Iodotyrosine deiodinase 1

Gene

Iyd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.By similarity

Catalytic activityi

L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.By similarity

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100Substrate1
Binding sitei157Substrate1
Binding sitei178Substrate1
Binding sitei275FMN1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 100FMN5
Nucleotide bindingi123 – 125FMN3
Nucleotide bindingi232 – 235FMN4

GO - Molecular functioni

  • iodide peroxidase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

BRENDAi1.22.1.1. 3474.
ReactomeiR-MMU-209968. Thyroxine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Iodotyrosine deiodinase 1 (EC:1.21.1.1)
Short name:
IYD-1
Alternative name(s):
Iodotyrosine dehalogenase 1
Gene namesi
Name:Iyd
Synonyms:Dehal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917587. Iyd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 210ExtracellularSequence analysisAdd BLAST187
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 285CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023027924 – 285Iodotyrosine deiodinase 1Add BLAST262

Proteomic databases

MaxQBiQ9DCX8.
PaxDbiQ9DCX8.
PeptideAtlasiQ9DCX8.
PRIDEiQ9DCX8.

PTM databases

iPTMnetiQ9DCX8.
PhosphoSitePlusiQ9DCX8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019762.
CleanExiMM_IYD.
GenevisibleiQ9DCX8. MM.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiQ9DCX8. 2 interactors.
MINTiMINT-1857005.
STRINGi10090.ENSMUSP00000019896.

Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi69 – 71Combined sources3
Helixi79 – 94Combined sources16
Helixi109 – 119Combined sources11
Helixi125 – 127Combined sources3
Beta strandi131 – 136Combined sources6
Helixi139 – 151Combined sources13
Turni159 – 161Combined sources3
Helixi163 – 169Combined sources7
Helixi170 – 172Combined sources3
Helixi180 – 183Combined sources4
Beta strandi184 – 193Combined sources10
Beta strandi203 – 205Combined sources3
Helixi209 – 226Combined sources18
Helixi237 – 239Combined sources3
Helixi240 – 246Combined sources7
Beta strandi253 – 262Combined sources10
Beta strandi269 – 271Combined sources3
Helixi278 – 280Combined sources3
Beta strandi282 – 284Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GB5X-ray2.00A34-285[»]
3GFDX-ray2.45A/B34-285[»]
3GH8X-ray2.61A/B/C/D/E/F/G/H34-285[»]
3TNZX-ray2.25A/B34-285[»]
3TO0X-ray2.66A/B34-285[»]
ProteinModelPortaliQ9DCX8.
SMRiQ9DCX8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DCX8.

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3936. Eukaryota.
COG0778. LUCA.
GeneTreeiENSGT00390000004348.
HOGENOMiHOG000146731.
HOVERGENiHBG055004.
InParanoidiQ9DCX8.
KOiK17231.
OMAiVHESVGI.
OrthoDBiEOG091G0CP8.
PhylomeDBiQ9DCX8.
TreeFamiTF313415.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLTPVLVA VVCILVVWVF KNADRNLEKK KEEAQVQPWV DEDLKDSTED
60 70 80 90 100
LQVEEDAEEW QEAEESVEHI PFSHTRYPEQ EMRMRSQEFY ELLNKRRSVR
110 120 130 140 150
FISSEHVPME VIENVIKAAG TAPSGAHTEP WTFVVVKDPD MKHKIREIIE
160 170 180 190 200
EEEEINYMKR MGKRWVTDLK KLRTNWIKEY LDTAPVLILI FKQVHGFAAN
210 220 230 240 250
GKKKVHYYNE ISVSIACGLL LAALQNAGLV TVTTTPLNCG PRLRVLLGRP
260 270 280
SHEKLLVLLP VGYPSRDATV PDLKRKALDQ IMVTV
Length:285
Mass (Da):32,814
Last modified:June 1, 2001 - v1
Checksum:i7B7415D6C28B1A58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002363 mRNA. Translation: BAB22041.1.
BC023358 mRNA. Translation: AAH23358.1.
CCDSiCCDS56670.1.
RefSeqiNP_081667.1. NM_027391.3.
UniGeneiMm.24153.

Genome annotation databases

EnsembliENSMUST00000019896; ENSMUSP00000019896; ENSMUSG00000019762.
GeneIDi70337.
KEGGimmu:70337.
UCSCiuc007ehp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002363 mRNA. Translation: BAB22041.1.
BC023358 mRNA. Translation: AAH23358.1.
CCDSiCCDS56670.1.
RefSeqiNP_081667.1. NM_027391.3.
UniGeneiMm.24153.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GB5X-ray2.00A34-285[»]
3GFDX-ray2.45A/B34-285[»]
3GH8X-ray2.61A/B/C/D/E/F/G/H34-285[»]
3TNZX-ray2.25A/B34-285[»]
3TO0X-ray2.66A/B34-285[»]
ProteinModelPortaliQ9DCX8.
SMRiQ9DCX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DCX8. 2 interactors.
MINTiMINT-1857005.
STRINGi10090.ENSMUSP00000019896.

PTM databases

iPTMnetiQ9DCX8.
PhosphoSitePlusiQ9DCX8.

Proteomic databases

MaxQBiQ9DCX8.
PaxDbiQ9DCX8.
PeptideAtlasiQ9DCX8.
PRIDEiQ9DCX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019896; ENSMUSP00000019896; ENSMUSG00000019762.
GeneIDi70337.
KEGGimmu:70337.
UCSCiuc007ehp.1. mouse.

Organism-specific databases

CTDi389434.
MGIiMGI:1917587. Iyd.

Phylogenomic databases

eggNOGiKOG3936. Eukaryota.
COG0778. LUCA.
GeneTreeiENSGT00390000004348.
HOGENOMiHOG000146731.
HOVERGENiHBG055004.
InParanoidiQ9DCX8.
KOiK17231.
OMAiVHESVGI.
OrthoDBiEOG091G0CP8.
PhylomeDBiQ9DCX8.
TreeFamiTF313415.

Enzyme and pathway databases

BRENDAi1.22.1.1. 3474.
ReactomeiR-MMU-209968. Thyroxine biosynthesis.

Miscellaneous databases

ChiTaRSiIyd. mouse.
EvolutionaryTraceiQ9DCX8.
PROiQ9DCX8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019762.
CleanExiMM_IYD.
GenevisibleiQ9DCX8. MM.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIYD1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.