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Protein

ATP synthase subunit d, mitochondrial

Gene

Atp5h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit d, mitochondrial
Short name:
ATPase subunit d
Gene namesi
Name:Atp5h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918929. Atp5h.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial proton-transporting ATP synthase, stator stalk Source: GO_Central
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • myelin sheath Source: UniProtKB
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000716742 – 161ATP synthase subunit d, mitochondrialAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei85N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei149N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DCX2.
MaxQBiQ9DCX2.
PaxDbiQ9DCX2.
PeptideAtlasiQ9DCX2.
PRIDEiQ9DCX2.
TopDownProteomicsiQ9DCX2.

2D gel databases

REPRODUCTION-2DPAGEQ9DCX2.

PTM databases

iPTMnetiQ9DCX2.
PhosphoSitePlusiQ9DCX2.
SwissPalmiQ9DCX2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034566.
ExpressionAtlasiQ9DCX2. baseline and differential.
GenevisibleiQ9DCX2. MM.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi214850. 2 interactors.
IntActiQ9DCX2. 5 interactors.
MINTiMINT-1842305.
STRINGi10090.ENSMUSP00000046256.

Structurei

3D structure databases

ProteinModelPortaliQ9DCX2.
SMRiQ9DCX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase d subunit family.Curated

Phylogenomic databases

eggNOGiKOG3366. Eukaryota.
ENOG4111IHJ. LUCA.
GeneTreeiENSGT00390000003582.
HOGENOMiHOG000267023.
HOVERGENiHBG050612.
InParanoidiQ9DCX2.
KOiK02138.
OMAiPYPQDKV.
OrthoDBiEOG091G0MQA.
PhylomeDBiQ9DCX2.
TreeFamiTF314031.

Family and domain databases

InterProiIPR008689. ATP_synth_F0_dsu_mt.
[Graphical view]
PANTHERiPTHR12700. PTHR12700. 1 hit.
PIRSFiPIRSF005514. ATPase_F0_D_mt. 1 hit.
SUPFAMiSSF161065. SSF161065. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRKLALKT IDWVSFVEVM PQNQKAIGNA LKSWNETFHA RLASLSEKPP
60 70 80 90 100
AIDWAYYRAN VAKPGLVDDF EKKYNALKIP VPEDKYTALV DQEEKEDVKS
110 120 130 140 150
CAEFVSGSQL RIQEYEKQLE KMRNIIPFDQ MTIDDLNEIF PETKLDKKKY
160
PYWPHQPIEN L
Length:161
Mass (Da):18,749
Last modified:January 23, 2007 - v3
Checksum:i380F3C6671D6DB4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → L in AAH16547 (PubMed:15489334).Curated1
Sequence conflicti159 – 161ENL → LMC AA sequence (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354051 mRNA. Translation: AAL83962.1.
AK002376 mRNA. Translation: BAB22053.1.
AK088617 mRNA. Translation: BAC40456.1.
AL627096 Genomic DNA. Translation: CAM22613.1.
BC016547 mRNA. Translation: AAH16547.1.
BC081431 mRNA. Translation: AAH81431.1.
CCDSiCCDS25633.1.
PIRiPN0046.
RefSeqiNP_082138.1. NM_027862.1.
XP_006534317.1. XM_006534254.1.
UniGeneiMm.371641.

Genome annotation databases

EnsembliENSMUST00000043931; ENSMUSP00000046256; ENSMUSG00000034566.
ENSMUST00000073791; ENSMUSP00000086072; ENSMUSG00000034566.
ENSMUST00000106537; ENSMUSP00000102147; ENSMUSG00000034566.
ENSMUST00000180072; ENSMUSP00000137071; ENSMUSG00000034566.
GeneIDi71679.
KEGGimmu:71679.
UCSCiuc007mhm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354051 mRNA. Translation: AAL83962.1.
AK002376 mRNA. Translation: BAB22053.1.
AK088617 mRNA. Translation: BAC40456.1.
AL627096 Genomic DNA. Translation: CAM22613.1.
BC016547 mRNA. Translation: AAH16547.1.
BC081431 mRNA. Translation: AAH81431.1.
CCDSiCCDS25633.1.
PIRiPN0046.
RefSeqiNP_082138.1. NM_027862.1.
XP_006534317.1. XM_006534254.1.
UniGeneiMm.371641.

3D structure databases

ProteinModelPortaliQ9DCX2.
SMRiQ9DCX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214850. 2 interactors.
IntActiQ9DCX2. 5 interactors.
MINTiMINT-1842305.
STRINGi10090.ENSMUSP00000046256.

PTM databases

iPTMnetiQ9DCX2.
PhosphoSitePlusiQ9DCX2.
SwissPalmiQ9DCX2.

2D gel databases

REPRODUCTION-2DPAGEQ9DCX2.

Proteomic databases

EPDiQ9DCX2.
MaxQBiQ9DCX2.
PaxDbiQ9DCX2.
PeptideAtlasiQ9DCX2.
PRIDEiQ9DCX2.
TopDownProteomicsiQ9DCX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043931; ENSMUSP00000046256; ENSMUSG00000034566.
ENSMUST00000073791; ENSMUSP00000086072; ENSMUSG00000034566.
ENSMUST00000106537; ENSMUSP00000102147; ENSMUSG00000034566.
ENSMUST00000180072; ENSMUSP00000137071; ENSMUSG00000034566.
GeneIDi71679.
KEGGimmu:71679.
UCSCiuc007mhm.1. mouse.

Organism-specific databases

CTDi10476.
MGIiMGI:1918929. Atp5h.

Phylogenomic databases

eggNOGiKOG3366. Eukaryota.
ENOG4111IHJ. LUCA.
GeneTreeiENSGT00390000003582.
HOGENOMiHOG000267023.
HOVERGENiHBG050612.
InParanoidiQ9DCX2.
KOiK02138.
OMAiPYPQDKV.
OrthoDBiEOG091G0MQA.
PhylomeDBiQ9DCX2.
TreeFamiTF314031.

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

ChiTaRSiAtp5h. mouse.
PROiQ9DCX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034566.
ExpressionAtlasiQ9DCX2. baseline and differential.
GenevisibleiQ9DCX2. MM.

Family and domain databases

InterProiIPR008689. ATP_synth_F0_dsu_mt.
[Graphical view]
PANTHERiPTHR12700. PTHR12700. 1 hit.
PIRSFiPIRSF005514. ATPase_F0_D_mt. 1 hit.
SUPFAMiSSF161065. SSF161065. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATP5H_MOUSE
AccessioniPrimary (citable) accession number: Q9DCX2
Secondary accession number(s): B1ASE1
, Q542H1, Q7M0I0, Q91YK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.