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Protein

ATP synthase subunit d, mitochondrial

Gene

Atp5h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit d, mitochondrial
Short name:
ATPase subunit d
Gene namesi
Name:Atp5h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918929 Atp5h

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000716742 – 161ATP synthase subunit d, mitochondrialAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei85N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei149N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DCX2
MaxQBiQ9DCX2
PaxDbiQ9DCX2
PeptideAtlasiQ9DCX2
PRIDEiQ9DCX2
TopDownProteomicsiQ9DCX2

2D gel databases

REPRODUCTION-2DPAGEiQ9DCX2

PTM databases

iPTMnetiQ9DCX2
PhosphoSitePlusiQ9DCX2
SwissPalmiQ9DCX2

Expressioni

Gene expression databases

BgeeiENSMUSG00000034566
ExpressionAtlasiQ9DCX2 baseline and differential
GenevisibleiQ9DCX2 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi214850, 3 interactors
IntActiQ9DCX2, 6 interactors
MINTiQ9DCX2
STRINGi10090.ENSMUSP00000046256

Structurei

3D structure databases

ProteinModelPortaliQ9DCX2
SMRiQ9DCX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase d subunit family.Curated

Phylogenomic databases

eggNOGiKOG3366 Eukaryota
ENOG4111IHJ LUCA
GeneTreeiENSGT00390000003582
HOGENOMiHOG000267023
HOVERGENiHBG050612
InParanoidiQ9DCX2
KOiK02138
OMAiRIQNYQK
OrthoDBiEOG091G0MQA
PhylomeDBiQ9DCX2
TreeFamiTF314031

Family and domain databases

Gene3Di1.20.58.880, 1 hit
InterProiView protein in InterPro
IPR008689 ATP_synth_F0_dsu_mt
IPR036228 ATP_synth_F0_dsu_sf_mt
PANTHERiPTHR12700 PTHR12700, 1 hit
PfamiView protein in Pfam
PF05873 Mt_ATP-synt_D, 1 hit
PIRSFiPIRSF005514 ATPase_F0_D_mt, 1 hit
SUPFAMiSSF161065 SSF161065, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRKLALKT IDWVSFVEVM PQNQKAIGNA LKSWNETFHA RLASLSEKPP
60 70 80 90 100
AIDWAYYRAN VAKPGLVDDF EKKYNALKIP VPEDKYTALV DQEEKEDVKS
110 120 130 140 150
CAEFVSGSQL RIQEYEKQLE KMRNIIPFDQ MTIDDLNEIF PETKLDKKKY
160
PYWPHQPIEN L
Length:161
Mass (Da):18,749
Last modified:January 23, 2007 - v3
Checksum:i380F3C6671D6DB4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → L in AAH16547 (PubMed:15489334).Curated1
Sequence conflicti159 – 161ENL → LMC AA sequence (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354051 mRNA Translation: AAL83962.1
AK002376 mRNA Translation: BAB22053.1
AK088617 mRNA Translation: BAC40456.1
AL627096 Genomic DNA No translation available.
BC016547 mRNA Translation: AAH16547.1
BC081431 mRNA Translation: AAH81431.1
CCDSiCCDS25633.1
PIRiPN0046
RefSeqiNP_082138.1, NM_027862.1
XP_006534317.1, XM_006534254.1
UniGeneiMm.371641

Genome annotation databases

EnsembliENSMUST00000043931; ENSMUSP00000046256; ENSMUSG00000034566
ENSMUST00000073791; ENSMUSP00000086072; ENSMUSG00000034566
ENSMUST00000106537; ENSMUSP00000102147; ENSMUSG00000034566
ENSMUST00000180072; ENSMUSP00000137071; ENSMUSG00000034566
GeneIDi71679
KEGGimmu:71679
UCSCiuc007mhm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATP5H_MOUSE
AccessioniPrimary (citable) accession number: Q9DCX2
Secondary accession number(s): B1ASE1
, Q542H1, Q7M0I0, Q91YK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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