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Protein

MAD2L1-binding protein

Gene

Mad2l1bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAD2L1-binding protein
Gene namesi
Name:Mad2l1bp
Synonyms:Mad2lbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913841. Mad2l1bp.

Subcellular locationi

  • Nucleusnucleoplasm By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963111 – 276MAD2L1-binding proteinAdd BLAST276

Proteomic databases

EPDiQ9DCX1.
MaxQBiQ9DCX1.
PaxDbiQ9DCX1.
PeptideAtlasiQ9DCX1.
PRIDEiQ9DCX1.

PTM databases

PhosphoSitePlusiQ9DCX1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034509.
CleanExiMM_MAD2L1BP.
GenevisibleiQ9DCX1. MM.

Interactioni

Subunit structurei

Interacts with MAD2L1.By similarity

Protein-protein interaction databases

BioGridi211577. 30 interactors.
IntActiQ9DCX1. 32 interactors.
MINTiMINT-218801.
STRINGi10090.ENSMUSP00000125915.

Structurei

3D structure databases

ProteinModelPortaliQ9DCX1.
SMRiQ9DCX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 81Interaction with MAD2L1By similarityAdd BLAST33

Sequence similaritiesi

Belongs to the MAD2L1BP family.Curated

Phylogenomic databases

eggNOGiENOG410IEGA. Eukaryota.
ENOG4111KKB. LUCA.
GeneTreeiENSGT00390000003812.
HOVERGENiHBG052442.
InParanoidiQ9DCX1.
OMAiRLAPNSM.
OrthoDBiEOG091G113C.
PhylomeDBiQ9DCX1.
TreeFamiTF331730.

Family and domain databases

InterProiIPR009511. MAD1/Cdc20-bound-Mad2-bd.
[Graphical view]
PfamiPF06581. p31comet. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGEEDMS ELSPAAAPNL DWYEKPEETH APEVDLETVI PPAQEPSNPA
60 70 80 90 100
EPFCPRDLVP VVFPGPVSQE DCCQFTCELL KHILYQRHQL PLPYEQLKHF
110 120 130 140 150
YRKVPQAEDT ARKKAWLATE ARNRKCQQAL AELESVLSHL RDFFARTLVP
160 170 180 190 200
QVLILLGGNA LSPKEFYELD LSRLAPFGVD QGLNTAACLR RLFRAIFLAD
210 220 230 240 250
PFSELQTPPL MGTIVMVQGH RDCGEDWFQP KLNYRVPSRG HKLTVTLSCG
260 270
RPSVPAMASE DYIWFQAPVT LKGFHE
Length:276
Mass (Da):31,140
Last modified:April 26, 2004 - v2
Checksum:i27C05DEBFD78D20D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51 – 52EP → DA in BAB22054 (PubMed:16141072).Curated2
Sequence conflicti104V → A in AAH05768 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002377 mRNA. Translation: BAB22054.1.
AK004224 mRNA. Translation: BAB23226.1.
BC005768 mRNA. Translation: AAH05768.1.
CCDSiCCDS28821.1.
RefSeqiNP_079925.2. NM_025649.3.
UniGeneiMm.272024.

Genome annotation databases

EnsembliENSMUST00000171172; ENSMUSP00000125915; ENSMUSG00000034509.
GeneIDi66591.
KEGGimmu:66591.
UCSCiuc008cru.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002377 mRNA. Translation: BAB22054.1.
AK004224 mRNA. Translation: BAB23226.1.
BC005768 mRNA. Translation: AAH05768.1.
CCDSiCCDS28821.1.
RefSeqiNP_079925.2. NM_025649.3.
UniGeneiMm.272024.

3D structure databases

ProteinModelPortaliQ9DCX1.
SMRiQ9DCX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211577. 30 interactors.
IntActiQ9DCX1. 32 interactors.
MINTiMINT-218801.
STRINGi10090.ENSMUSP00000125915.

PTM databases

PhosphoSitePlusiQ9DCX1.

Proteomic databases

EPDiQ9DCX1.
MaxQBiQ9DCX1.
PaxDbiQ9DCX1.
PeptideAtlasiQ9DCX1.
PRIDEiQ9DCX1.

Protocols and materials databases

DNASUi66591.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171172; ENSMUSP00000125915; ENSMUSG00000034509.
GeneIDi66591.
KEGGimmu:66591.
UCSCiuc008cru.2. mouse.

Organism-specific databases

CTDi9587.
MGIiMGI:1913841. Mad2l1bp.

Phylogenomic databases

eggNOGiENOG410IEGA. Eukaryota.
ENOG4111KKB. LUCA.
GeneTreeiENSGT00390000003812.
HOVERGENiHBG052442.
InParanoidiQ9DCX1.
OMAiRLAPNSM.
OrthoDBiEOG091G113C.
PhylomeDBiQ9DCX1.
TreeFamiTF331730.

Miscellaneous databases

PROiQ9DCX1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034509.
CleanExiMM_MAD2L1BP.
GenevisibleiQ9DCX1. MM.

Family and domain databases

InterProiIPR009511. MAD1/Cdc20-bound-Mad2-bd.
[Graphical view]
PfamiPF06581. p31comet. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMD2BP_MOUSE
AccessioniPrimary (citable) accession number: Q9DCX1
Secondary accession number(s): Q99J05, Q9D0Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.