Q9DCV6 (DELE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Death ligand signal enhancer

Gene names

Name:	Kiaa0141
Synonyms:	Dele

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation By similarity.
Subunit structure	Interacts with DAP3 By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Contains 7 TPR repeats.
Sequence caution	The sequence BAD32178.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Repeat TPR repeat Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 101	101	Mitochondrion Potential
	Chain	102 – 510	409	Death ligand signal enhancer		PRO_0000050722
Regions
	Repeat	213 – 245	33	TPR 1
	Repeat	246 – 278	33	TPR 2
	Repeat	279 – 313	35	TPR 3
	Repeat	314 – 351	38	TPR 4
	Repeat	352 – 385	34	TPR 5
	Repeat	386 – 423	38	TPR 6
	Repeat	471 – 499	29	TPR 7

Sequences

	Sequence		Length	Mass (Da)
	Q9DCV6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 54B911DF9F23ADFE	FASTA	510	55,430
	10 20 30 40 50 60 MWRLTGILGR ALPRLLGPGF RGITPKPTSS DGSQTTSPTL PLTRLSFDRS GSHGSKRSRD 70 80 90 100 110 120 PKCCGWKDAF HWMSAHVSPN TLRDAISWGT LAVLALHLAR QIHFHAPLVA GPQPAERSWH 130 140 150 160 170 180 SPLYRFLSSS WWHPHSSLRR HVLPRSDCPA PRNTGLREPR QGQEDHPSAP SQCLPSDSSL 190 200 210 220 230 240 RSGLLNLPEE EPSDFDFLHA SRDFASQAKA AEAHPPGGKN EQDKAKALPL EEAVTSIQQL 250 260 270 280 290 300 FQLSVAITFN FLGTENIKTG DYTAAFSYFQ KAADRGYSKA QYNVGLCLEH GRGTPRDLSK 310 320 330 340 350 360 AILFYHLAAV QGHSLAQYRY ARCLLQSPGS LSDPERERAV SLLKQAADSG LTEAQAFLGV 370 380 390 400 410 420 LFTKEPHLDE QRAVKYLWLA ASNGDSQSRF HLGICYEKGL GAQRNLGEAV KCYQQAAAMG 430 440 450 460 470 480 NEPARERLRT LFNVEAAGPS HLATTGLKSF SSPSLCSLNT LLAGASGLPH ASSTGNLGLL 490 500 510 CRSGHLGASH GAPSRTIPSL ERSLVRLGFG

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed: 15368895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryonic intestine.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002437 mRNA. Translation: BAB22100.1. AK172900 mRNA. Translation: BAD32178.1. Different initiation.
IPI	IPI00331373.
RefSeq	NP_077141.2. NM_024179.5.
UniGene	Mm.281086.
3D structure databases
ProteinModelPortal	Q9DCV6.
SMR	Q9DCV6. Positions 235-452.
ModBase	Search...
Proteomic databases
PRIDE	Q9DCV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025314; ENSMUSP00000025314; ENSMUSG00000024442.
GeneID	66839.
KEGG	mmu:66839.
UCSC	uc008erz.2. mouse.
Organism-specific databases
MGI	MGI:1914089. 0610009O20Rik.
Rouge	Search...
Phylogenomic databases
GeneTree	ENSGT00390000002137.
HOGENOM	HBG125710.
HOVERGEN	HBG052169.
InParanoid	Q9DCV6.
OMA	PRHTGLR.
OrthoDB	EOG4SN1PP.
Gene expression databases
ArrayExpress	Q9DCV6.
Bgee	Q9DCV6.
CleanEx	MM_0610009O20RIK.
Genevestigator	Q9DCV6.
GermOnline	ENSMUSG00000024442. Mus musculus.
Family and domain databases
InterPro	IPR006597. Sel1-like. IPR011990. TPR-like_helical. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF08238. Sel1. 5 hits. [Graphical view]
SMART	SM00671. SEL1. 5 hits. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	322787.
SOURCE	Search...

Entry information

Entry name

DELE_MOUSE

Accession

Primary (citable) accession number: Q9DCV6
Secondary accession number(s): Q6A0B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program