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Q9DCU9

- HOGA1_MOUSE

UniProt

Q9DCU9 - HOGA1_MOUSE

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Protein

4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

Hoga1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the final step in the metabolic pathway of hydroxyproline.By similarity

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulationi

Inhibited by divalent cations.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei162 – 1621Involved in proton transfer during cleavageBy similarity
Active sitei190 – 1901Schiff-base intermediate with substrateBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Binding sitei216 – 2161Substrate; via carbonyl oxygenBy similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB

GO - Biological processi

  1. 4-hydroxyproline catabolic process Source: Ensembl
  2. glyoxylate catabolic process Source: UniProtKB
  3. oxalate metabolic process Source: Ensembl
  4. pyruvate biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name:
Probable KHG-aldolase
Gene namesi
Name:Hoga1
Synonyms:Dhdpsl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1914682. Hoga1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionBy similarityAdd
BLAST
Chaini24 – 3212984-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000273347Add
BLAST

Proteomic databases

MaxQBiQ9DCU9.
PaxDbiQ9DCU9.
PRIDEiQ9DCU9.

PTM databases

PhosphoSiteiQ9DCU9.

Expressioni

Gene expression databases

BgeeiQ9DCU9.
CleanExiMM_0610010D20RIK.
ExpressionAtlasiQ9DCU9. baseline and differential.
GenevestigatoriQ9DCU9.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9DCU9. 2 interactions.
MINTiMINT-1860303.

Structurei

3D structure databases

ProteinModelPortaliQ9DCU9.
SMRiQ9DCU9. Positions 27-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni71 – 722Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DapA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0329.
GeneTreeiENSGT00530000063604.
HOVERGENiHBG081405.
InParanoidiQ9DCU9.
KOiK18123.
OMAiLADHENI.
PhylomeDBiQ9DCU9.
TreeFamiTF324600.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
PROSITEiPS00666. DHDPS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCU9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGPQIWASM RQGLSRGLSR NVKGKKVDIA GIYPPVTTPF TATAEVDYGK
60 70 80 90 100
LEENLNRLAT FPFRGFVVQG STGEFPFLTS LERLEVVSRV RQAIPKDKFL
110 120 130 140 150
IAGSGCESTQ ATVEMTVSMA QVGADVAMVV TPCYYRGRMS SAALIHHYTK
160 170 180 190 200
VADVSPIPVV LYSVPANTGL ELPVDAVVTL SQHPNIIGLK DSGGDVTRIG
210 220 230 240 250
LIVHKTSKQD FQVLAGSAGF LLASYAVGAV GGICGLANVL GAQVCQLERL
260 270 280 290 300
CLTGQWEAAQ ELQHRLIEPN TAVTRRFGIP GLKKTMDWFG YYGGPCRAPL
310 320
QELSPTEEEA LRLDFSNNGW L
Length:321
Mass (Da):34,644
Last modified:June 1, 2001 - v1
Checksum:i75B3DC959756D5A7
GO

Sequence cautioni

The sequence BAB27226.1 differs from that shown. Reason: Frameshift at position 270.
The sequence AAH16430.1 differs from that shown. Reason: Erroneous termination at position 322. Translated as stop.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251K → M in BAB27226. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002457 mRNA. Translation: BAB22114.1.
AK010857 mRNA. Translation: BAB27226.1. Frameshift.
BC016430 mRNA. Translation: AAH16430.1. Sequence problems.
CCDSiCCDS29820.1.
RefSeqiNP_080428.1. NM_026152.1.
UniGeneiMm.24196.

Genome annotation databases

EnsembliENSMUST00000081714; ENSMUSP00000080414; ENSMUSG00000025176.
GeneIDi67432.
KEGGimmu:67432.
UCSCiuc008hnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002457 mRNA. Translation: BAB22114.1 .
AK010857 mRNA. Translation: BAB27226.1 . Frameshift.
BC016430 mRNA. Translation: AAH16430.1 . Sequence problems.
CCDSi CCDS29820.1.
RefSeqi NP_080428.1. NM_026152.1.
UniGenei Mm.24196.

3D structure databases

ProteinModelPortali Q9DCU9.
SMRi Q9DCU9. Positions 27-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DCU9. 2 interactions.
MINTi MINT-1860303.

PTM databases

PhosphoSitei Q9DCU9.

Proteomic databases

MaxQBi Q9DCU9.
PaxDbi Q9DCU9.
PRIDEi Q9DCU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081714 ; ENSMUSP00000080414 ; ENSMUSG00000025176 .
GeneIDi 67432.
KEGGi mmu:67432.
UCSCi uc008hnb.1. mouse.

Organism-specific databases

CTDi 112817.
MGIi MGI:1914682. Hoga1.

Phylogenomic databases

eggNOGi COG0329.
GeneTreei ENSGT00530000063604.
HOVERGENi HBG081405.
InParanoidi Q9DCU9.
KOi K18123.
OMAi LADHENI.
PhylomeDBi Q9DCU9.
TreeFami TF324600.

Miscellaneous databases

ChiTaRSi HOGA1. mouse.
NextBioi 324548.
PROi Q9DCU9.
SOURCEi Search...

Gene expression databases

Bgeei Q9DCU9.
CleanExi MM_0610010D20RIK.
ExpressionAtlasi Q9DCU9. baseline and differential.
Genevestigatori Q9DCU9.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Dihydrodipicolinate_synth_AS.
[Graphical view ]
PANTHERi PTHR12128. PTHR12128. 1 hit.
Pfami PF00701. DHDPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF001365. DHDPS. 1 hit.
PRINTSi PR00146. DHPICSNTHASE.
PROSITEi PS00666. DHDPS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiHOGA1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCU9
Secondary accession number(s): Q91W74, Q9CY60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3