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Protein

39S ribosomal protein L4, mitochondrial

Gene

Mrpl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L4, mitochondrial
Short name:
L4mt
Short name:
MRP-L4
Gene namesi
Name:Mrpl4
ORF Names:MNCb-3848
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2137210. Mrpl4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
  • ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29429439S ribosomal protein L4, mitochondrialPRO_0000238950Add
BLAST

Proteomic databases

EPDiQ9DCU6.
MaxQBiQ9DCU6.
PaxDbiQ9DCU6.
PRIDEiQ9DCU6.

PTM databases

PhosphoSiteiQ9DCU6.

Expressioni

Gene expression databases

BgeeiQ9DCU6.
CleanExiMM_MRPL4.
GenevisibleiQ9DCU6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DCU6. 1 interaction.
MINTiMINT-4129938.
STRINGi10090.ENSMUSP00000003386.

Structurei

3D structure databases

ProteinModelPortaliQ9DCU6.
SMRiQ9DCU6. Positions 45-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.Curated

Phylogenomic databases

eggNOGiKOG1624. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000014512.
HOGENOMiHOG000248767.
HOVERGENiHBG083638.
InParanoidiQ9DCU6.
KOiK02926.
OMAiQENVEWQ.
OrthoDBiEOG7F512T.
PhylomeDBiQ9DCU6.
TreeFamiTF313913.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR023574. Ribosomal_L4_dom.
IPR013005. Ribosomal_uL4/L1e.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DCU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLFQAASR ASLRLSGSRV IHSLAEGAER PAEISEPRDS AGLLDPVLRK
60 70 80 90 100
CELRIPVHRR PVQAWVESLR GFEQERIGLA ELHPDVFATA PRLDIVHQVA
110 120 130 140 150
IWQRNFRRIS YANTKTRAEV SGGGRKPWQQ KGSGRARHGS IRSPLWRGGG
160 170 180 190 200
VAHGPRGPTS YYYMLPMKVR ALGLKVALTV KLMQDDLHIV DSLELPTADP
210 220 230 240 250
QYLTELAQYR HWGSSVLLVD LTHEEMPKNV VAATSGLNSF NLIPAVGLNV
260 270 280 290
YSMLKHQTLV LTLPSVAFLE DKLLWQDSRY TPLYPFRLPY SDFP
Length:294
Mass (Da):33,073
Last modified:June 1, 2001 - v1
Checksum:iEED72D7728ABEB02
GO

Sequence cautioni

The sequence AAH37064.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA95082.1 differs from that shown. Reason: Frameshift at position 120. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471R → L in BAA95082 (Ref. 2) Curated
Sequence conflicti268 – 2681F → L in BAA95082 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049634 mRNA. Translation: BAB40839.1.
AB041599 mRNA. Translation: BAA95082.1. Frameshift.
AK002464 mRNA. Translation: BAB22118.1.
BC037064 mRNA. Translation: AAH37064.1. Different initiation.
BC039983 mRNA. Translation: AAH39983.2.
BC061095 mRNA. Translation: AAH61095.1.
CCDSiCCDS40548.1.
RefSeqiNP_075656.2. NM_023167.2.
UniGeneiMm.427576.

Genome annotation databases

EnsembliENSMUST00000003386; ENSMUSP00000003386; ENSMUSG00000003299.
GeneIDi66163.
KEGGimmu:66163.
UCSCiuc009oju.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049634 mRNA. Translation: BAB40839.1.
AB041599 mRNA. Translation: BAA95082.1. Frameshift.
AK002464 mRNA. Translation: BAB22118.1.
BC037064 mRNA. Translation: AAH37064.1. Different initiation.
BC039983 mRNA. Translation: AAH39983.2.
BC061095 mRNA. Translation: AAH61095.1.
CCDSiCCDS40548.1.
RefSeqiNP_075656.2. NM_023167.2.
UniGeneiMm.427576.

3D structure databases

ProteinModelPortaliQ9DCU6.
SMRiQ9DCU6. Positions 45-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DCU6. 1 interaction.
MINTiMINT-4129938.
STRINGi10090.ENSMUSP00000003386.

PTM databases

PhosphoSiteiQ9DCU6.

Proteomic databases

EPDiQ9DCU6.
MaxQBiQ9DCU6.
PaxDbiQ9DCU6.
PRIDEiQ9DCU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003386; ENSMUSP00000003386; ENSMUSG00000003299.
GeneIDi66163.
KEGGimmu:66163.
UCSCiuc009oju.1. mouse.

Organism-specific databases

CTDi51073.
MGIiMGI:2137210. Mrpl4.

Phylogenomic databases

eggNOGiKOG1624. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000014512.
HOGENOMiHOG000248767.
HOVERGENiHBG083638.
InParanoidiQ9DCU6.
KOiK02926.
OMAiQENVEWQ.
OrthoDBiEOG7F512T.
PhylomeDBiQ9DCU6.
TreeFamiTF313913.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ9DCU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCU6.
CleanExiMM_MRPL4.
GenevisibleiQ9DCU6. MM.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR023574. Ribosomal_L4_dom.
IPR013005. Ribosomal_uL4/L1e.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain, Colon and Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRM04_MOUSE
AccessioniPrimary (citable) accession number: Q9DCU6
Secondary accession number(s): Q811L8, Q8JZU9, Q9JJB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.