Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plasmolipin

Gene

Pllp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene namesi
Name:Pllp
Synonyms:Plapi, Pmlp, Tm4sf11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915051. Pllp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 68ExtracellularSequence analysisAdd BLAST12
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 141ExtracellularSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 182CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568141 – 182PlasmolipinAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DCU2.
PeptideAtlasiQ9DCU2.
PRIDEiQ9DCU2.

PTM databases

iPTMnetiQ9DCU2.
PhosphoSitePlusiQ9DCU2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031775.
CleanExiMM_PLLP.
GenevisibleiQ9DCU2. MM.

Interactioni

Subunit structurei

Hexamer arranged as a trimer of two plasmolipin subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034227.

Structurei

3D structure databases

ProteinModelPortaliQ9DCU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 166MARVELPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiQ9DCU2.
OMAiVLMIFNV.
OrthoDBiEOG091G0RE7.
PhylomeDBiQ9DCU2.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPSKVST RTSSPAQGVG ASVSALRPDL GFVRSALGVL ALLQLALGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLLIFFVA ATVLYITAFI ACAAAVDLTS LRGSRPYNQR SAASFFACLV
160 170 180
MIAYGVSAFF SFQAWRGVGS NAATSQMAGG YS
Length:182
Mass (Da):19,801
Last modified:June 1, 2001 - v1
Checksum:iF2D78E5E22173B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298129, AJ298130 Genomic DNA. Translation: CAC88126.1.
AK002477 mRNA. Translation: BAB22130.1.
AK032540 mRNA. Translation: BAC27916.1.
BC024534 mRNA. Translation: AAH24534.1.
CCDSiCCDS22546.1.
RefSeqiNP_080661.1. NM_026385.4.
UniGeneiMm.279977.

Genome annotation databases

EnsembliENSMUST00000034227; ENSMUSP00000034227; ENSMUSG00000031775.
GeneIDi67801.
KEGGimmu:67801.
UCSCiuc009mwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298129, AJ298130 Genomic DNA. Translation: CAC88126.1.
AK002477 mRNA. Translation: BAB22130.1.
AK032540 mRNA. Translation: BAC27916.1.
BC024534 mRNA. Translation: AAH24534.1.
CCDSiCCDS22546.1.
RefSeqiNP_080661.1. NM_026385.4.
UniGeneiMm.279977.

3D structure databases

ProteinModelPortaliQ9DCU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034227.

PTM databases

iPTMnetiQ9DCU2.
PhosphoSitePlusiQ9DCU2.

Proteomic databases

PaxDbiQ9DCU2.
PeptideAtlasiQ9DCU2.
PRIDEiQ9DCU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034227; ENSMUSP00000034227; ENSMUSG00000031775.
GeneIDi67801.
KEGGimmu:67801.
UCSCiuc009mwv.1. mouse.

Organism-specific databases

CTDi51090.
MGIiMGI:1915051. Pllp.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiQ9DCU2.
OMAiVLMIFNV.
OrthoDBiEOG091G0RE7.
PhylomeDBiQ9DCU2.
TreeFamiTF316174.

Miscellaneous databases

PROiQ9DCU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031775.
CleanExiMM_PLLP.
GenevisibleiQ9DCU2. MM.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLLP_MOUSE
AccessioniPrimary (citable) accession number: Q9DCU2
Secondary accession number(s): Q544Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.