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Protein

Membrane progestin receptor gamma

Gene

Paqr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation.By similarity

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor gammaBy similarity
Short name:
mPR gammaBy similarity
Alternative name(s):
Membrane progesterone P4 receptor gammaBy similarity
Membrane progesterone receptor gammaBy similarity
Progesterone and adipoQ receptor family member 5
Progestin and adipoQ receptor family member 5By similarity
Progestin and adipoQ receptor family member V
Gene namesi
Name:Paqr5Imported
Synonyms:Mprg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921340. Paqr5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 81ExtracellularSequence analysis9
Transmembranei82 – 101Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini102 – 113CytoplasmicSequence analysisAdd BLAST12
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 141ExtracellularSequence analysis7
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 186CytoplasmicSequence analysisAdd BLAST24
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 253ExtracellularSequence analysisAdd BLAST46
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 294CytoplasmicSequence analysisAdd BLAST20
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 330ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188441 – 330Membrane progestin receptor gammaAdd BLAST330

Proteomic databases

PaxDbiQ9DCU0.
PRIDEiQ9DCU0.

PTM databases

PhosphoSitePlusiQ9DCU0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032278.
CleanExiMM_PAQR5.
ExpressionAtlasiQ9DCU0. baseline and differential.
GenevisibleiQ9DCU0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034817.

Structurei

3D structure databases

ProteinModelPortaliQ9DCU0.
SMRiQ9DCU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000067790.
HOVERGENiHBG052505.
InParanoidiQ9DCU0.
OMAiKNARHIC.
OrthoDBiEOG091G0NO8.
PhylomeDBiQ9DCU0.
TreeFamiTF319738.

Family and domain databases

InterProiView protein in InterPro
IPR004254. AdipoR/HlyIII-related.
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiView protein in Pfam
PF03006. HlyIII. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DCU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLKLPRLF RIDQVPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL
60 70 80 90 100
NIWTHLLPFW FFVWRFMTAL YVTDIQNDSY SWPMLVYMCT SCVYPLASSC
110 120 130 140 150
AHTFSSMSKN ARHICYFLDY GAVNLFSLGS AIAYSAYTFP DALVCSTFHE
160 170 180 190 200
CYVALAVLNT ILSTGLSCYS RFLELQKPRL CKLLRVLAFA YPYTWDSLPI
210 220 230 240 250
FYRLFLFPGE SSRNEAMLYH QKHMGMTLLA SFFYSAHLPE RLAPGRFDYI
260 270 280 290 300
GHSHQLFHVC VILATHLQME AILLDKTLRR EWLLATSRPF SFPQIAAAML
310 320 330
LCIIFSLSNI IYFSAALYRI PEPELHEKET
Length:330
Mass (Da):38,151
Last modified:June 1, 2001 - v1
Checksum:iA68EE63260F2214D
GO

Sequence cautioni

The sequence AAH54855 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC35142 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424294 mRNA. Translation: AAR08382.1.
AK002481 mRNA. Translation: BAB22133.1.
AK035475 mRNA. Translation: BAC29072.1.
AK052776 mRNA. Translation: BAC35142.1. Different initiation.
AK085411 mRNA. Translation: BAC39443.1.
AK086679 mRNA. Translation: BAC39718.1.
BC054855 mRNA. Translation: AAH54855.1. Sequence problems.
CCDSiCCDS23261.1.
RefSeqiNP_083024.1. NM_028748.2.
UniGeneiMm.273267.

Genome annotation databases

EnsembliENSMUST00000034817; ENSMUSP00000034817; ENSMUSG00000032278.
GeneIDi74090.
KEGGimmu:74090.
UCSCiuc009qaa.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPAQR5_MOUSE
AccessioniPrimary (citable) accession number: Q9DCU0
Secondary accession number(s): Q7TPQ5, Q8C6Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families