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Q9DCT8

- CRIP2_MOUSE

UniProt

Q9DCT8 - CRIP2_MOUSE

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Protein
Cysteine-rich protein 2
Gene
Crip2, Crp2, Hlp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. hemopoiesis Source: MGI
  2. positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Heart LIM protein
Gene namesi
Name:Crip2
Synonyms:Crp2, Hlp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1915587. Crip2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. extracellular matrix Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Cysteine-rich protein 2
PRO_0000075711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysine1 Publication
Modified residuei138 – 1381N6-acetyllysine1 Publication
Modified residuei144 – 1441N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9DCT8.
PaxDbiQ9DCT8.
PRIDEiQ9DCT8.

PTM databases

PhosphoSiteiQ9DCT8.

Expressioni

Developmental stagei

In the embryo, its expression is primarily restricted to the developing heart. In situ hybridization showed expression at E7.75 in the paired heart-forming primordia prior to linear heart-tube formation. At E8.5, strong expression is detected in the heart, with equal expression in both heart chambers. Expression is detected in both myocardium and endocardium, and in vascular endothelium. Later in fetal development low levels of expression is detected outside the heart, including dorsal root ganglia and the spinal cord. In the adult, it is expressed at highest levels in the heart, and at lower levels in the brain, skeletal muscle and aorta.1 Publication

Gene expression databases

ArrayExpressiQ9DCT8.
BgeeiQ9DCT8.
CleanExiMM_CRIP2.
GenevestigatoriQ9DCT8.

Interactioni

Subunit structurei

Interacts with TGFB1I1.1 Publication

Protein-protein interaction databases

IntActiQ9DCT8. 5 interactions.
MINTiMINT-1863492.

Structurei

3D structure databases

ProteinModelPortaliQ9DCT8.
SMRiQ9DCT8. Positions 1-63, 126-184.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5753LIM zinc-binding 1
Add
BLAST
Domaini126 – 17853LIM zinc-binding 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7311Gly-rich
Add
BLAST
Compositional biasi180 – 19415Gly-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG246818.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiQ9DCT8.
OMAiIEGQTAP.
OrthoDBiEOG7CK39M.
PhylomeDBiQ9DCT8.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCT8-1 [UniParc]FASTAAdd to Basket

« Hide

MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCNKTLT PGGHAEHDGK    50
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP QTEAPQVTGP IEVPVVRTEE 100
RKTSGPPKGP SKASSVTTFT GEPNMCPRCN KRVYFAEKVT SLGKDWHRPC 150
LRCERCSKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDK 200
DPEGTVQP 208
Length:208
Mass (Da):22,727
Last modified:June 1, 2001 - v1
Checksum:i9A3AEF8A8FBA1D19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF469648 mRNA. Translation: AAM89218.1.
AF470625 Genomic DNA. Translation: AAM89219.1.
AF450245 Genomic DNA. Translation: AAM97586.1.
AK002484 mRNA. Translation: BAB22136.1.
BC002093 mRNA. Translation: AAH02093.1.
BC002096 mRNA. Translation: AAH02096.1.
CCDSiCCDS26204.1.
RefSeqiNP_077185.1. NM_024223.2.
UniGeneiMm.133825.

Genome annotation databases

EnsembliENSMUST00000084882; ENSMUSP00000081943; ENSMUSG00000006356.
GeneIDi68337.
KEGGimmu:68337.
UCSCiuc007pfy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF469648 mRNA. Translation: AAM89218.1 .
AF470625 Genomic DNA. Translation: AAM89219.1 .
AF450245 Genomic DNA. Translation: AAM97586.1 .
AK002484 mRNA. Translation: BAB22136.1 .
BC002093 mRNA. Translation: AAH02093.1 .
BC002096 mRNA. Translation: AAH02096.1 .
CCDSi CCDS26204.1.
RefSeqi NP_077185.1. NM_024223.2.
UniGenei Mm.133825.

3D structure databases

ProteinModelPortali Q9DCT8.
SMRi Q9DCT8. Positions 1-63, 126-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DCT8. 5 interactions.
MINTi MINT-1863492.

PTM databases

PhosphoSitei Q9DCT8.

Proteomic databases

MaxQBi Q9DCT8.
PaxDbi Q9DCT8.
PRIDEi Q9DCT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084882 ; ENSMUSP00000081943 ; ENSMUSG00000006356 .
GeneIDi 68337.
KEGGi mmu:68337.
UCSCi uc007pfy.2. mouse.

Organism-specific databases

CTDi 1397.
MGIi MGI:1915587. Crip2.

Phylogenomic databases

eggNOGi NOG246818.
GeneTreei ENSGT00550000074548.
HOGENOMi HOG000111234.
HOVERGENi HBG051143.
InParanoidi Q9DCT8.
OMAi IEGQTAP.
OrthoDBi EOG7CK39M.
PhylomeDBi Q9DCT8.
TreeFami TF313758.

Miscellaneous databases

ChiTaRSi CRIP2. mouse.
NextBioi 327013.
PROi Q9DCT8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DCT8.
Bgeei Q9DCT8.
CleanExi MM_CRIP2.
Genevestigatori Q9DCT8.

Family and domain databases

Gene3Di 2.10.110.10. 2 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00132. LIM. 2 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family."
    Yu T.S., Moctezuma-Anaya M., Kubo A., Keller G., Robertson S.
    Mech. Dev. 116:187-192(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE.
    Strain: 129/Sv.
    Tissue: Heart.
  2. "The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression."
    Zhou J., Ashouian N., Delepine M., Matsuda F., Chevillard C., Riblet R., Schildkraut C.L., Birshtein B.K.
    Proc. Natl. Acad. Sci. U.S.A. 99:13693-13698(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo."
    Kim-Kaneyama J.-R., Suzuki W., Ichikawa K., Ohki T., Kohno Y., Sata M., Nose K., Shibanuma M.
    J. Cell Sci. 118:937-949(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TGFB1I1.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23; LYS-138 AND LYS-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCRIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DCT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi