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Protein

Cysteine-rich protein 2

Gene

Crip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: MGI
  • positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Heart LIM protein
Gene namesi
Name:Crip2
Synonyms:Crp2, Hlp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1915587. Crip2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: MGI
  • extracellular matrix Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757111 – 208Cysteine-rich protein 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei104PhosphoserineBy similarity1
Modified residuei138N6-acetyllysineCombined sources1
Modified residuei144N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DCT8.
MaxQBiQ9DCT8.
PaxDbiQ9DCT8.
PRIDEiQ9DCT8.
TopDownProteomicsiQ9DCT8.

PTM databases

iPTMnetiQ9DCT8.
PhosphoSitePlusiQ9DCT8.
SwissPalmiQ9DCT8.

Expressioni

Developmental stagei

In the embryo, its expression is primarily restricted to the developing heart. In situ hybridization showed expression at E7.75 in the paired heart-forming primordia prior to linear heart-tube formation. At E8.5, strong expression is detected in the heart, with equal expression in both heart chambers. Expression is detected in both myocardium and endocardium, and in vascular endothelium. Later in fetal development low levels of expression is detected outside the heart, including dorsal root ganglia and the spinal cord. In the adult, it is expressed at highest levels in the heart, and at lower levels in the brain, skeletal muscle and aorta.1 Publication

Gene expression databases

BgeeiENSMUSG00000006356.
CleanExiMM_CRIP2.
ExpressionAtlasiQ9DCT8. baseline and differential.
GenevisibleiQ9DCT8. MM.

Interactioni

Subunit structurei

Interacts with TGFB1I1.1 Publication

Protein-protein interaction databases

IntActiQ9DCT8. 5 interactors.
MINTiMINT-1863492.
STRINGi10090.ENSMUSP00000081943.

Structurei

3D structure databases

ProteinModelPortaliQ9DCT8.
SMRiQ9DCT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini126 – 178LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 73Gly-richAdd BLAST11
Compositional biasi180 – 194Gly-richAdd BLAST15

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI5. Eukaryota.
ENOG410XUEW. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiQ9DCT8.
OMAiYCKAHFE.
OrthoDBiEOG091G11RX.
PhylomeDBiQ9DCT8.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCNKTLT PGGHAEHDGK
60 70 80 90 100
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP QTEAPQVTGP IEVPVVRTEE
110 120 130 140 150
RKTSGPPKGP SKASSVTTFT GEPNMCPRCN KRVYFAEKVT SLGKDWHRPC
160 170 180 190 200
LRCERCSKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDK

DPEGTVQP
Length:208
Mass (Da):22,727
Last modified:June 1, 2001 - v1
Checksum:i9A3AEF8A8FBA1D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469648 mRNA. Translation: AAM89218.1.
AF470625 Genomic DNA. Translation: AAM89219.1.
AF450245 Genomic DNA. Translation: AAM97586.1.
AK002484 mRNA. Translation: BAB22136.1.
BC002093 mRNA. Translation: AAH02093.1.
BC002096 mRNA. Translation: AAH02096.1.
CCDSiCCDS26204.1.
RefSeqiNP_077185.1. NM_024223.2.
UniGeneiMm.133825.

Genome annotation databases

EnsembliENSMUST00000084882; ENSMUSP00000081943; ENSMUSG00000006356.
GeneIDi68337.
KEGGimmu:68337.
UCSCiuc007pfy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469648 mRNA. Translation: AAM89218.1.
AF470625 Genomic DNA. Translation: AAM89219.1.
AF450245 Genomic DNA. Translation: AAM97586.1.
AK002484 mRNA. Translation: BAB22136.1.
BC002093 mRNA. Translation: AAH02093.1.
BC002096 mRNA. Translation: AAH02096.1.
CCDSiCCDS26204.1.
RefSeqiNP_077185.1. NM_024223.2.
UniGeneiMm.133825.

3D structure databases

ProteinModelPortaliQ9DCT8.
SMRiQ9DCT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DCT8. 5 interactors.
MINTiMINT-1863492.
STRINGi10090.ENSMUSP00000081943.

PTM databases

iPTMnetiQ9DCT8.
PhosphoSitePlusiQ9DCT8.
SwissPalmiQ9DCT8.

Proteomic databases

EPDiQ9DCT8.
MaxQBiQ9DCT8.
PaxDbiQ9DCT8.
PRIDEiQ9DCT8.
TopDownProteomicsiQ9DCT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084882; ENSMUSP00000081943; ENSMUSG00000006356.
GeneIDi68337.
KEGGimmu:68337.
UCSCiuc007pfy.2. mouse.

Organism-specific databases

CTDi1397.
MGIiMGI:1915587. Crip2.

Phylogenomic databases

eggNOGiENOG410ITI5. Eukaryota.
ENOG410XUEW. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111234.
HOVERGENiHBG051143.
InParanoidiQ9DCT8.
OMAiYCKAHFE.
OrthoDBiEOG091G11RX.
PhylomeDBiQ9DCT8.
TreeFamiTF313758.

Miscellaneous databases

ChiTaRSiCrip2. mouse.
PROiQ9DCT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006356.
CleanExiMM_CRIP2.
ExpressionAtlasiQ9DCT8. baseline and differential.
GenevisibleiQ9DCT8. MM.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DCT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.