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Protein

Cysteine-rich protein 2

Gene

Crip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: MGI
  • positive regulation of cell proliferation Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2
Short name:
CRP-2
Alternative name(s):
Heart LIM protein
Gene namesi
Name:Crip2
Synonyms:Crp2, Hlp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1915587 Crip2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757111 – 208Cysteine-rich protein 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei104PhosphoserineBy similarity1
Modified residuei138N6-acetyllysineCombined sources1
Modified residuei144N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DCT8
MaxQBiQ9DCT8
PaxDbiQ9DCT8
PRIDEiQ9DCT8
TopDownProteomicsiQ9DCT8

PTM databases

iPTMnetiQ9DCT8
PhosphoSitePlusiQ9DCT8
SwissPalmiQ9DCT8

Expressioni

Developmental stagei

In the embryo, its expression is primarily restricted to the developing heart. In situ hybridization showed expression at E7.75 in the paired heart-forming primordia prior to linear heart-tube formation. At E8.5, strong expression is detected in the heart, with equal expression in both heart chambers. Expression is detected in both myocardium and endocardium, and in vascular endothelium. Later in fetal development low levels of expression is detected outside the heart, including dorsal root ganglia and the spinal cord. In the adult, it is expressed at highest levels in the heart, and at lower levels in the brain, skeletal muscle and aorta.1 Publication

Gene expression databases

BgeeiENSMUSG00000006356
CleanExiMM_CRIP2
ExpressionAtlasiQ9DCT8 baseline and differential
GenevisibleiQ9DCT8 MM

Interactioni

Subunit structurei

Interacts with TGFB1I1.1 Publication

Protein-protein interaction databases

BioGridi212808, 1 interactor
IntActiQ9DCT8, 6 interactors
MINTiQ9DCT8
STRINGi10090.ENSMUSP00000081943

Structurei

3D structure databases

ProteinModelPortaliQ9DCT8
SMRiQ9DCT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini126 – 178LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 73Gly-richAdd BLAST11
Compositional biasi180 – 194Gly-richAdd BLAST15

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI5 Eukaryota
ENOG410XUEW LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111234
HOVERGENiHBG051143
InParanoidiQ9DCT8
OMAiSYIYDKP
OrthoDBiEOG091G11RX
PhylomeDBiQ9DCT8
TreeFamiTF313758

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9DCT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCNKTLT PGGHAEHDGK
60 70 80 90 100
PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP QTEAPQVTGP IEVPVVRTEE
110 120 130 140 150
RKTSGPPKGP SKASSVTTFT GEPNMCPRCN KRVYFAEKVT SLGKDWHRPC
160 170 180 190 200
LRCERCSKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDK

DPEGTVQP
Length:208
Mass (Da):22,727
Last modified:June 1, 2001 - v1
Checksum:i9A3AEF8A8FBA1D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469648 mRNA Translation: AAM89218.1
AF470625 Genomic DNA Translation: AAM89219.1
AF450245 Genomic DNA Translation: AAM97586.1
AK002484 mRNA Translation: BAB22136.1
BC002093 mRNA Translation: AAH02093.1
BC002096 mRNA Translation: AAH02096.1
CCDSiCCDS26204.1
RefSeqiNP_001334372.1, NM_001347443.1
NP_077185.1, NM_024223.2
UniGeneiMm.133825

Genome annotation databases

EnsembliENSMUST00000084882; ENSMUSP00000081943; ENSMUSG00000006356
GeneIDi68337
KEGGimmu:68337
UCSCiuc007pfy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCRIP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DCT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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