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Q9DCT8

- CRIP2_MOUSE

UniProt

Q9DCT8 - CRIP2_MOUSE

Protein

Cysteine-rich protein 2

Gene

Crip2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. hemopoiesis Source: MGI
    2. positive regulation of cell proliferation Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich protein 2
    Short name:
    CRP-2
    Alternative name(s):
    Heart LIM protein
    Gene namesi
    Name:Crip2
    Synonyms:Crp2, Hlp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1915587. Crip2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: MGI
    2. extracellular matrix Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Cysteine-rich protein 2PRO_0000075711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231N6-acetyllysine1 Publication
    Modified residuei138 – 1381N6-acetyllysine1 Publication
    Modified residuei144 – 1441N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9DCT8.
    PaxDbiQ9DCT8.
    PRIDEiQ9DCT8.

    PTM databases

    PhosphoSiteiQ9DCT8.

    Expressioni

    Developmental stagei

    In the embryo, its expression is primarily restricted to the developing heart. In situ hybridization showed expression at E7.75 in the paired heart-forming primordia prior to linear heart-tube formation. At E8.5, strong expression is detected in the heart, with equal expression in both heart chambers. Expression is detected in both myocardium and endocardium, and in vascular endothelium. Later in fetal development low levels of expression is detected outside the heart, including dorsal root ganglia and the spinal cord. In the adult, it is expressed at highest levels in the heart, and at lower levels in the brain, skeletal muscle and aorta.1 Publication

    Gene expression databases

    ArrayExpressiQ9DCT8.
    BgeeiQ9DCT8.
    CleanExiMM_CRIP2.
    GenevestigatoriQ9DCT8.

    Interactioni

    Subunit structurei

    Interacts with TGFB1I1.1 Publication

    Protein-protein interaction databases

    IntActiQ9DCT8. 5 interactions.
    MINTiMINT-1863492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCT8.
    SMRiQ9DCT8. Positions 1-63, 126-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 5753LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini126 – 17853LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi63 – 7311Gly-richAdd
    BLAST
    Compositional biasi180 – 19415Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG246818.
    GeneTreeiENSGT00550000074548.
    HOGENOMiHOG000111234.
    HOVERGENiHBG051143.
    InParanoidiQ9DCT8.
    OMAiIEGQTAP.
    OrthoDBiEOG7CK39M.
    PhylomeDBiQ9DCT8.
    TreeFamiTF313758.

    Family and domain databases

    Gene3Di2.10.110.10. 2 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 2 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DCT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCNKTLT PGGHAEHDGK    50
    PFCHKPCYAT LFGPKGVNIG GAGSYIYEKP QTEAPQVTGP IEVPVVRTEE 100
    RKTSGPPKGP SKASSVTTFT GEPNMCPRCN KRVYFAEKVT SLGKDWHRPC 150
    LRCERCSKTL TPGGHAEHDG QPYCHKPCYG ILFGPKGVNT GAVGSYIYDK 200
    DPEGTVQP 208
    Length:208
    Mass (Da):22,727
    Last modified:June 1, 2001 - v1
    Checksum:i9A3AEF8A8FBA1D19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF469648 mRNA. Translation: AAM89218.1.
    AF470625 Genomic DNA. Translation: AAM89219.1.
    AF450245 Genomic DNA. Translation: AAM97586.1.
    AK002484 mRNA. Translation: BAB22136.1.
    BC002093 mRNA. Translation: AAH02093.1.
    BC002096 mRNA. Translation: AAH02096.1.
    CCDSiCCDS26204.1.
    RefSeqiNP_077185.1. NM_024223.2.
    UniGeneiMm.133825.

    Genome annotation databases

    EnsembliENSMUST00000084882; ENSMUSP00000081943; ENSMUSG00000006356.
    GeneIDi68337.
    KEGGimmu:68337.
    UCSCiuc007pfy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF469648 mRNA. Translation: AAM89218.1 .
    AF470625 Genomic DNA. Translation: AAM89219.1 .
    AF450245 Genomic DNA. Translation: AAM97586.1 .
    AK002484 mRNA. Translation: BAB22136.1 .
    BC002093 mRNA. Translation: AAH02093.1 .
    BC002096 mRNA. Translation: AAH02096.1 .
    CCDSi CCDS26204.1.
    RefSeqi NP_077185.1. NM_024223.2.
    UniGenei Mm.133825.

    3D structure databases

    ProteinModelPortali Q9DCT8.
    SMRi Q9DCT8. Positions 1-63, 126-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DCT8. 5 interactions.
    MINTi MINT-1863492.

    PTM databases

    PhosphoSitei Q9DCT8.

    Proteomic databases

    MaxQBi Q9DCT8.
    PaxDbi Q9DCT8.
    PRIDEi Q9DCT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084882 ; ENSMUSP00000081943 ; ENSMUSG00000006356 .
    GeneIDi 68337.
    KEGGi mmu:68337.
    UCSCi uc007pfy.2. mouse.

    Organism-specific databases

    CTDi 1397.
    MGIi MGI:1915587. Crip2.

    Phylogenomic databases

    eggNOGi NOG246818.
    GeneTreei ENSGT00550000074548.
    HOGENOMi HOG000111234.
    HOVERGENi HBG051143.
    InParanoidi Q9DCT8.
    OMAi IEGQTAP.
    OrthoDBi EOG7CK39M.
    PhylomeDBi Q9DCT8.
    TreeFami TF313758.

    Miscellaneous databases

    ChiTaRSi CRIP2. mouse.
    NextBioi 327013.
    PROi Q9DCT8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DCT8.
    Bgeei Q9DCT8.
    CleanExi MM_CRIP2.
    Genevestigatori Q9DCT8.

    Family and domain databases

    Gene3Di 2.10.110.10. 2 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 2 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family."
      Yu T.S., Moctezuma-Anaya M., Kubo A., Keller G., Robertson S.
      Mech. Dev. 116:187-192(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE.
      Strain: 129/Sv.
      Tissue: Heart.
    2. "The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression."
      Zhou J., Ashouian N., Delepine M., Matsuda F., Chevillard C., Riblet R., Schildkraut C.L., Birshtein B.K.
      Proc. Natl. Acad. Sci. U.S.A. 99:13693-13698(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo."
      Kim-Kaneyama J.-R., Suzuki W., Ichikawa K., Ohki T., Kohno Y., Sata M., Nose K., Shibanuma M.
      J. Cell Sci. 118:937-949(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TGFB1I1.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23; LYS-138 AND LYS-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiCRIP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3