Q9DCT6 (BAP18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromatin complexes subunit BAP18

Alternative name(s):
BPTF-associated protein of 18 kDa

Gene names

Name:

Bap18

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of chromatin complexes such as the MLL1/MLL and NURF complexes By similarity.
Subunit structure	Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the nucleosome-remodeling factor (NURF) complex By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 SANT domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Chromatin regulator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MLL1 complex Inferred from sequence or structural similarity. Source: UniProtKB NURF complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9DCT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9DCT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Isoform 3 (identifier: Q9DCT6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.

Isoform 4 (identifier: Q9DCT6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Chromatin complexes subunit BAP18		PRO_0000264252
Regions
	Domain	38 – 83	46	SANT
Amino acid modifications
	Modified residue	36	1	Phosphoserine By similarity
	Modified residue	96	1	Phosphoserine Ref.4 Ref.5
Natural variations
	Alternative sequence	41 – 74	34	Missing in isoform 3 and isoform 4.		VSP_021892
	Alternative sequence	137 – 171	35	VTLSA…NFDQA → SLTLDSGLLTTSADAPLLSC in isoform 2 and isoform 4.		VSP_021893

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E7D10D1429D0BABF	FASTA	171	17,996
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD 70 80 90 100 110 120 LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS 130 140 150 160 170 SVPEAGVPPI KKQKADVTLS ALNDSDANSD LVDVEGLGET PPAKKLNFDQ A
	Isoform 2 [UniParc]. Checksum: 5C0E7A3235E3500C	FASTA	156	16,330
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD 70 80 90 100 110 120 LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS 130 140 150 SVPEAGVPPI KKQKADSLTL DSGLLTTSAD APLLSC
	Isoform 3 [UniParc]. Checksum: 2E8ACD3296217841	FASTA	137	14,054
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA QIKTTVKRKV YEDSGIPLPA 70 80 90 100 110 120 ESPKKGPKKM TSGVLSPPNA PPPSSSSVPE AGVPPIKKQK ADVTLSALND SDANSDLVDV 130 EGLGETPPAK KLNFDQA
	Isoform 4 [UniParc]. Checksum: 686BA4E3F584A4DD	FASTA	122	12,387
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA QIKTTVKRKV YEDSGIPLPA 70 80 90 100 110 120 ESPKKGPKKM TSGVLSPPNA PPPSSSSVPE AGVPPIKKQK ADSLTLDSGL LTTSADAPLL SC

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Strain: C57BL/6J. Tissue: Embryo, Embryonic heart and Kidney.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: NMRI. Tissue: Mammary gland.
[4]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY. Tissue: Melanoma.
[5]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed: 19131326] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002491 mRNA. Translation: BAB22140.1. AK003842 mRNA. Translation: BAB23031.1. AK169173 mRNA. Translation: BAE40952.1. AK170380 mRNA. Translation: BAE41758.1. AL669869 Genomic DNA. Translation: CAI35229.1. AL669869 Genomic DNA. Translation: CAI35230.1. BC055357 mRNA. Translation: AAH55357.1.
IPI	IPI00265101. IPI00408937. IPI00654032. IPI00757518.
RefSeq	NP_001171072.1. NM_001177601.1. NP_001171074.1. NM_001177603.1. NP_001171077.1. NM_001177606.1. NP_001171078.1. NM_001177607.1. NP_081033.1. NM_026757.2. NP_665701.1. NM_145758.1.
UniGene	Mm.39265.
3D structure databases
ProteinModelPortal	Q9DCT6.
SMR	Q9DCT6. Positions 35-81.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9DCT6.
PTM databases
PhosphoSite	Q9DCT6.
Proteomic databases
PRIDE	Q9DCT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021181; ENSMUSP00000021181; ENSMUSG00000020831. ENSMUST00000102569; ENSMUSP00000099629; ENSMUSG00000020831. ENSMUST00000108578; ENSMUSP00000104219; ENSMUSG00000020831. ENSMUST00000108579; ENSMUSP00000104220; ENSMUSG00000020831.
GeneID	104457.
KEGG	mmu:104457.
NMPDR	fig|10090.3.peg.24551.
Organism-specific databases
MGI	MGI:1915609. 0610010K14Rik.
Phylogenomic databases
GeneTree	ENSGT00390000014721.
HOVERGEN	HBG056647.
OMA	VAQIKST.
PhylomeDB	Q9DCT6.
Gene expression databases
ArrayExpress	Q9DCT6.
Bgee	Q9DCT6.
CleanEx	MM_0610010K14RIK.
Genevestigator	Q9DCT6.
GermOnline	ENSMUSG00000020831. Mus musculus.
Family and domain databases
InterPro	IPR009057. Homeodomain-like. IPR001005. SANT_DNA-bd. [Graphical view]
SMART	SM00717. SANT. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS51293. SANT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	357140.
SOURCE	Search...

Entry information

Entry name

BAP18_MOUSE

Accession

Primary (citable) accession number: Q9DCT6
Secondary accession number(s): Q3TFE6, Q7TMP3, Q9D183

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 1, 2001
Last modified:	September 21, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program