Reviewed, UniProtKB/Swiss-Prot Q9DCT6 (CQ049_MOUSE)

Names and origin

Protein names	Recommended name:     Uncharacterized potential DNA-binding protein C17orf49 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 SANT domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9DCT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9DCT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Isoform 3 (identifier: Q9DCT6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.

Isoform 4 (identifier: Q9DCT6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Uncharacterized potential DNA-binding protein C17orf49 homolog		PRO_0000264252
Regions
	Domain	38 – 83	46	SANT
Amino acid modifications
	Modified residue	36	1	Phosphoserine By similarity
	Modified residue	96	1	Phosphoserine Ref.4 Ref.5
Natural variations
	Alternative sequence	41 – 74	34	Missing in isoform 3 and isoform 4.		VSP_021892
	Alternative sequence	137 – 171	35	VTLSA…NFDQA → SLTLDSGLLTTSADAPLLSC in isoform 2 and isoform 4.		VSP_021893

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E7D10D1429D0BABF	FASTA	171	17,996
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD 70 80 90 100 110 120 LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS 130 140 150 160 170 SVPEAGVPPI KKQKADVTLS ALNDSDANSD LVDVEGLGET PPAKKLNFDQ A
	Isoform 2. Checksum: 5C0E7A3235E3500C	FASTA	156	16,330
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD 70 80 90 100 110 120 LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS 130 140 150 SVPEAGVPPI KKQKADSLTL DSGLLTTSAD APLLSC
	Isoform 3. Checksum: 2E8ACD3296217841	FASTA	137	14,054
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA QIKTTVKRKV YEDSGIPLPA 70 80 90 100 110 120 ESPKKGPKKM TSGVLSPPNA PPPSSSSVPE AGVPPIKKQK ADVTLSALND SDANSDLVDV 130 EGLGETPPAK KLNFDQA
	Isoform 4. Checksum: 686BA4E3F584A4DD	FASTA	122	12,387
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA QIKTTVKRKV YEDSGIPLPA 70 80 90 100 110 120 ESPKKGPKKM TSGVLSPPNA PPPSSSSVPE AGVPPIKKQK ADSLTLDSGL LTTSADAPLL SC

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Strain: C57BL/6J. Tissue: Embryo, Embryonic heart and Kidney.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: NMRI. Tissue: Mammary gland.
[4]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY.
[5]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed: 19131326] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002491 mRNA. Translation: BAB22140.1. AK003842 mRNA. Translation: BAB23031.1. AK169173 mRNA. Translation: BAE40952.1. AK170380 mRNA. Translation: BAE41758.1. AL669869 Genomic DNA. Translation: CAI35229.1. AL669869 Genomic DNA. Translation: CAI35230.1. BC055357 mRNA. Translation: AAH55357.1.
IPI	IPI00265101. IPI00408937. IPI00654032. IPI00757518.
RefSeq	NP_081033.1.
UniGene	Mm.39265
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9DCT6.
Proteomic databases
PRIDE	Q9DCT6.
Genome annotation databases
Ensembl	ENSMUST00000021181; ENSMUSP00000021181; ENSMUSG00000020831; Mus musculus. [Genome view] ENSMUST00000081826; ENSMUSP00000080510; ENSMUSG00000020831; Mus musculus. [Genome view] ENSMUST00000102569; ENSMUSP00000099629; ENSMUSG00000020831; Mus musculus. [Genome view] ENSMUST00000108578; ENSMUSP00000104219; ENSMUSG00000020831; Mus musculus. [Genome view]
GeneID	104457.
KEGG	mmu:104457.
NMPDR	fig|10090.3.peg.24551.
UCSC	uc007jud.1. mouse. uc007jue.1. mouse. uc007jug.1. mouse. uc007juh.1. mouse.
Organism-specific databases
MGI	MGI:1915609. 0610010K14Rik.
Phylogenomic databases
HOVERGEN	Q9DCT6.
OMA	WTDTEIE.
Gene expression databases
ArrayExpress	Q9DCT6.
Bgee	Q9DCT6.
CleanEx	MM_0610010K14RIK.
Genevestigator	Q9DCT6.
GermOnline	ENSMUSG00000020831. Mus musculus.
Family and domain databases
InterPro	IPR001005. SANT_DNA-bd. [Graphical view]
SMART	SM00717. SANT. 1 hit. [Graphical view]
PROSITE	PS51293. SANT. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	357140.

Entry information

Entry name

CQ049_MOUSE

Accession

Primary (citable) accession number: Q9DCT6
Secondary accession number(s): Q3TFE6, Q7TMP3, Q9D183

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 1, 2001
Last modified:	November 24, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)