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Protein

Chromatin complexes subunit BAP18

Gene

Bap18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of chromatin complexes such as the MLL1/MLL and NURF complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin complexes subunit BAP18
Alternative name(s):
BPTF-associated protein of 18 kDa
Gene namesi
Name:Bap18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915609. 0610010K14Rik.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642521 – 171Chromatin complexes subunit BAP18Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DCT6.
PeptideAtlasiQ9DCT6.
PRIDEiQ9DCT6.

PTM databases

iPTMnetiQ9DCT6.
PhosphoSitePlusiQ9DCT6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020831.
CleanExiMM_0610010K14RIK.
ExpressionAtlasiQ9DCT6. baseline and differential.
GenevisibleiQ9DCT6. MM.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the nucleosome-remodeling factor (NURF) complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi222642. 2 interactors.
IntActiQ9DCT6. 2 interactors.
STRINGi10090.ENSMUSP00000104216.

Structurei

3D structure databases

ProteinModelPortaliQ9DCT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 83SANTAdd BLAST46

Sequence similaritiesi

Contains 1 SANT domain.Curated

Phylogenomic databases

eggNOGiKOG4834. Eukaryota.
ENOG4111K4E. LUCA.
GeneTreeiENSGT00390000014721.
HOVERGENiHBG056647.
InParanoidiQ9DCT6.
PhylomeDBiQ9DCT6.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DCT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML
60 70 80 90 100
RAAVKRFGDD LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG
110 120 130 140 150
PKKMTSGVLS PPNAPPPSSS SVPEAGVPPI KKQKADVTLS ALNDSDANSD
160 170
LVDVEGLGET PPAKKLNFDQ A
Length:171
Mass (Da):17,996
Last modified:June 1, 2001 - v1
Checksum:iE7D10D1429D0BABF
GO
Isoform 2 (identifier: Q9DCT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Show »
Length:156
Mass (Da):16,330
Checksum:i5C0E7A3235E3500C
GO
Isoform 3 (identifier: Q9DCT6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.

Show »
Length:137
Mass (Da):14,054
Checksum:i2E8ACD3296217841
GO
Isoform 4 (identifier: Q9DCT6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Show »
Length:122
Mass (Da):12,387
Checksum:i686BA4E3F584A4DD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02189241 – 74Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_021893137 – 171VTLSA…NFDQA → SLTLDSGLLTTSADAPLLSC in isoform 2 and isoform 4. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002491 mRNA. Translation: BAB22140.1.
AK003842 mRNA. Translation: BAB23031.1.
AK169173 mRNA. Translation: BAE40952.1.
AK170380 mRNA. Translation: BAE41758.1.
AL669869 Genomic DNA. Translation: CAI35229.1.
AL669869 Genomic DNA. Translation: CAI35230.1.
BC055357 mRNA. Translation: AAH55357.1.
CCDSiCCDS24940.1. [Q9DCT6-3]
CCDS48832.1. [Q9DCT6-4]
CCDS48833.1. [Q9DCT6-2]
CCDS48835.1. [Q9DCT6-1]
RefSeqiNP_001171072.1. NM_001177601.1.
NP_001171074.1. NM_001177603.1. [Q9DCT6-2]
NP_001171077.1. NM_001177606.1. [Q9DCT6-4]
NP_001171078.1. NM_001177607.1.
NP_081033.1. NM_026757.2. [Q9DCT6-3]
NP_665701.1. NM_145758.1. [Q9DCT6-1]
UniGeneiMm.30016.
Mm.39265.

Genome annotation databases

EnsembliENSMUST00000021181; ENSMUSP00000021181; ENSMUSG00000020831. [Q9DCT6-2]
ENSMUST00000102569; ENSMUSP00000099629; ENSMUSG00000020831. [Q9DCT6-3]
ENSMUST00000108578; ENSMUSP00000104219; ENSMUSG00000020831. [Q9DCT6-1]
ENSMUST00000108579; ENSMUSP00000104220; ENSMUSG00000020831. [Q9DCT6-4]
GeneIDi104457.
KEGGimmu:104457.
UCSCiuc007jud.2. mouse. [Q9DCT6-2]
uc007jue.2. mouse. [Q9DCT6-4]
uc007jug.2. mouse. [Q9DCT6-3]
uc007juh.2. mouse. [Q9DCT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002491 mRNA. Translation: BAB22140.1.
AK003842 mRNA. Translation: BAB23031.1.
AK169173 mRNA. Translation: BAE40952.1.
AK170380 mRNA. Translation: BAE41758.1.
AL669869 Genomic DNA. Translation: CAI35229.1.
AL669869 Genomic DNA. Translation: CAI35230.1.
BC055357 mRNA. Translation: AAH55357.1.
CCDSiCCDS24940.1. [Q9DCT6-3]
CCDS48832.1. [Q9DCT6-4]
CCDS48833.1. [Q9DCT6-2]
CCDS48835.1. [Q9DCT6-1]
RefSeqiNP_001171072.1. NM_001177601.1.
NP_001171074.1. NM_001177603.1. [Q9DCT6-2]
NP_001171077.1. NM_001177606.1. [Q9DCT6-4]
NP_001171078.1. NM_001177607.1.
NP_081033.1. NM_026757.2. [Q9DCT6-3]
NP_665701.1. NM_145758.1. [Q9DCT6-1]
UniGeneiMm.30016.
Mm.39265.

3D structure databases

ProteinModelPortaliQ9DCT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222642. 2 interactors.
IntActiQ9DCT6. 2 interactors.
STRINGi10090.ENSMUSP00000104216.

PTM databases

iPTMnetiQ9DCT6.
PhosphoSitePlusiQ9DCT6.

Proteomic databases

PaxDbiQ9DCT6.
PeptideAtlasiQ9DCT6.
PRIDEiQ9DCT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021181; ENSMUSP00000021181; ENSMUSG00000020831. [Q9DCT6-2]
ENSMUST00000102569; ENSMUSP00000099629; ENSMUSG00000020831. [Q9DCT6-3]
ENSMUST00000108578; ENSMUSP00000104219; ENSMUSG00000020831. [Q9DCT6-1]
ENSMUST00000108579; ENSMUSP00000104220; ENSMUSG00000020831. [Q9DCT6-4]
GeneIDi104457.
KEGGimmu:104457.
UCSCiuc007jud.2. mouse. [Q9DCT6-2]
uc007jue.2. mouse. [Q9DCT6-4]
uc007jug.2. mouse. [Q9DCT6-3]
uc007juh.2. mouse. [Q9DCT6-1]

Organism-specific databases

MGIiMGI:1915609. 0610010K14Rik.

Phylogenomic databases

eggNOGiKOG4834. Eukaryota.
ENOG4111K4E. LUCA.
GeneTreeiENSGT00390000014721.
HOVERGENiHBG056647.
InParanoidiQ9DCT6.
PhylomeDBiQ9DCT6.

Miscellaneous databases

ChiTaRSi0610010K14Rik. mouse.
PROiQ9DCT6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020831.
CleanExiMM_0610010K14RIK.
ExpressionAtlasiQ9DCT6. baseline and differential.
GenevisibleiQ9DCT6. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBAP18_MOUSE
AccessioniPrimary (citable) accession number: Q9DCT6
Secondary accession number(s): Q3TFE6, Q7TMP3, Q9D183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.